Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion

Interferon lambda protects the female reproductive tract against Zika virus infection

(2019) Elizabeth A. Caine et al.   Nature Communications

Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin

(2019) Liang Ye et al.   NATURE IMMUNOLOGY

Interferon Lambda Inhibits Bacterial Uptake During Influenza Super-Infection

(2019) Helen E. Rich et al.   INFECTION AND IMMUNITY

A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis

(2019) Sanghyun Lee et al.   Cell Host & Microbe

Shared and Distinct Functions of Type I and Type III Interferons

(2019) Helen M. Lazear et al.   IMMUNITY

Noncanonical IFN Signaling, Steroids, and STATs: A Probable Role of V-ATPase

(2019) Howard M. Johnson et al.   MEDIATORS OF INFLAMMATION

Nasal commensal Staphylococcus epidermidis enhances interferon-λ-dependent immunity against influenza virus

(2019) Hyun Jik Kim et al.   Microbiome

Viral complementation of immunodeficiency confers protection against enteric pathogens via interferon-λ

(2019) Harshad Ingle et al.   Nature Microbiology

Type-Specific Crosstalk Modulates Interferon Signaling in Intestinal Epithelial Cells

(2019) Kalliopi Pervolaraki et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

The IFN-λ4 Conundrum: When a Good Interferon Goes Bad

(2019) Olusegun O. Onabajo et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Interferon-λ modulates dendritic cells to facilitate T cell immunity during infection with influenza A virus

(2019) Emily A. Hemann et al.   NATURE IMMUNOLOGY

Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons

(2019) Adriana Forero et al.   IMMUNITY

Type I and type III interferons differ in their adjuvant activities for influenza vaccines

(2019) Liang Ye et al.   JOURNAL OF VIROLOGY

Interferon lambda receptor 1 (IFNL1R) transcript is highly expressed in rhinovirus bronchiolitis and correlates with disease severity

(2018) Alessandra Pierangeli et al.   JOURNAL OF CLINICAL VIROLOGY

Differential Responses by Human Respiratory Epithelial Cell Lines to Respiratory Syncytial Virus Reflect Distinct Patterns of Infection Control

(2018) Philippa Hillyer et al.   JOURNAL OF VIROLOGY

Respiratory syncytial virus activates epidermal growth factor receptor to suppress interferon regulatory factor 1-dependent interferon-lambda and antiviral defense in airway epithelium

(2018) A Kalinowski et al.   Mucosal Immunology

Tropism for tuft cells determines immune promotion of norovirus pathogenesis

(2018) Craig B. Wilen et al.   SCIENCE

The Role of Interferon in Persistent Viral Infection: Insights from Murine Norovirus

(2018) Timothy J. Nice et al.   TRENDS IN MICROBIOLOGY

Distinct Effects of Type I and III Interferons on Enteric Viruses

(2018) Harshad Ingle et al.   Viruses-Basel

IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

(2018) Jonas Klinkhammer et al.   eLife

Influenza

(2018) Florian Krammer et al.   Nature Reviews Disease Primers

Murine colitis reveals a disease-associated bacteriophage community

(2018) Breck A. Duerkop et al.   Nature Microbiology

IL-1β activation in response to Staphylococcus aureus lung infection requires inflammasome-dependent and independent mechanisms

(2018) Sílvia Pires et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance

(2018) Kalliopi Pervolaraki et al.   PLoS Pathogens

Lambda interferons come to light: dual function cytokines mediating antiviral immunity and damage control

(2018) Evangelos Andreakos et al.   CURRENT OPINION IN IMMUNOLOGY

IL-28-Dependent Activation of Epithelial STAT1 Drives Epithelial Wound Healing in Inflammatory Bowel Disease

(2017) Mircea Chiriac et al.   GASTROENTEROLOGY

Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

(2017) Ioanna E. Galani et al.   IMMUNITY

SOCS1 is an inducible negative regulator of interferon λ (IFN-λ)–induced gene expressionin vivo

(2017) Tanja Blumer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of NK Cells in IL-28B–Mediated Immunity against Influenza Virus Infection

(2017) Yanshi Wang et al.   JOURNAL OF IMMUNOLOGY

Type III IFNs Are Commonly Induced by Bacteria-Sensing TLRs and Reinforce Epithelial Barriers during Infection

(2017) Charlotte Odendall et al.   JOURNAL OF IMMUNOLOGY

Impact of Type I and III Interferons on Respiratory Superinfections Due to Multidrug-Resistant Pathogens

(2017) Dane Parker   JOURNAL OF INFECTIOUS DISEASES

Interferon lambda1/IL-29 and inorganic polyphosphate are novel regulators of neutrophil-driven thromboinflammation

(2017) Akrivi Chrysanthopoulou et al.   JOURNAL OF PATHOLOGY

Expression of Ifnlr1 on Intestinal Epithelial Cells Is Critical to the Antiviral Effects of Interferon Lambda against Norovirus and Reovirus

(2017) Megan T. Baldridge et al.   JOURNAL OF VIROLOGY

A paradox of transcriptional and functional innate interferon responses of human intestinal enteroids to enteric virus infection

(2017) Kapil Saxena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal–fetal interface

(2017) Jacqueline Corry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type III Interferon-Mediated Signaling Is Critical for Controlling Live Attenuated Yellow Fever Virus Infection In Vivo

(2017) Florian Douam et al.   mBio

The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy

(2017) Janina Bruening et al.   Journal of Immunology Research

Cell Polarization and Epigenetic Status Shape the Heterogeneous Response to Type III Interferons in Intestinal Epithelial Cells

(2017) Sudeep Bhushal et al.   Frontiers in Immunology

Interferon-λs and Plasmacytoid Dendritic Cells: A Close Relationship

(2017) Giulia Finotti et al.   Frontiers in Immunology

Interferon (IFN)-λ Takes the Helm: Immunomodulatory Roles of Type III IFNs

(2017) Ivan Zanoni et al.   Frontiers in Immunology

Interferon Lambda Genetics and Biology in Regulation of Viral Control

(2017) Emily A. Hemann et al.   Frontiers in Immunology

Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut

(2017) Kalliopi Pervolaraki et al.   Frontiers in Immunology

Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection

(2016) Avraham Bayer et al.   Cell Host & Microbe

Synergistic production of TNFα and IFNα by human pDCs incubated with IFNλ3 and IL-3

(2016) Giulia Finotti et al.   CYTOKINE

IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment

(2016) Sophia Davidson et al.   EMBO Molecular Medicine

Enteric Viruses Ameliorate Gut Inflammation via Toll-like Receptor 3 and Toll-like Receptor 7-Mediated Interferon-β Production

(2016) Jin-Young Yang et al.   IMMUNITY

Interferon lambda 4 expression is suppressed by the host during viral infection

(2016) MeeAe Hong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Immune Cell Profiling of IFN-λ Response Shows pDCs Express Highest Level of IFN-λR1 and Are Directly Responsive via the JAK-STAT Pathway

(2016) Aoife Kelly et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Peginterferon Lambda-1a/Ribavirin with Daclatasvir or Peginterferon Alfa-2a/Ribavirin with Telaprevir for Chronic Hepatitis C Genotype 1b

(2016) Robert Flisiak et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Lambda Interferon Restructures the Nasal Microbiome and Increases Susceptibility to Staphylococcus aureus Superinfection

(2016) Paul J. Planet et al.   mBio

Type I Interferon Receptor Deficiency in Dendritic Cells Facilitates Systemic Murine Norovirus Persistence Despite Enhanced Adaptive Immunity

(2016) Timothy J. Nice et al.   PLoS Pathogens

Distinct Roles of Type I and Type III Interferons in Intestinal Immunity to Homologous and Heterologous Rotavirus Infections

(2016) Jian-Da Lin et al.   PLoS Pathogens

Type III Interferons in Hepatitis C Virus Infection

(2016) Maude Boisvert et al.   Frontiers in Immunology

A Randomized Study of Peginterferon Lambda-1a Compared to Peginterferon Alfa-2a in Combination with Ribavirin and Telaprevir in Patients with Genotype-1 Chronic Hepatitis C

(2016) Robert Flisiak et al.   PLoS One

Disease-Specific Alterations in the Enteric Virome in Inflammatory Bowel Disease

(2015) Jason M. Norman et al.   CELL

Norovirus

(2015) Elizabeth Robilotti et al.   CLINICAL MICROBIOLOGY REVIEWS

Interferon-λ: Immune Functions at Barrier Surfaces and Beyond

(2015) Helen M. Lazear et al.   IMMUNITY

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production

(2015) Katrina Blazek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Endogenously produced TNF-α contributes to the expression of CXCL10/IP-10 in IFN-λ3-activated plasmacytoid dendritic cells

(2015) Giulia Finotti et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Noncanonical Effects of IRF9 in Intestinal Inflammation: More than Type I and Type III Interferons

(2015) Isabella Rauch et al.   MOLECULAR AND CELLULAR BIOLOGY

Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection

(2015) Pedro P Hernández et al.   NATURE IMMUNOLOGY

Guarding the frontiers: the biology of type III interferons

(2015) Andreas Wack et al.   NATURE IMMUNOLOGY

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

(2015) Helen M. Lazear et al.   Science Translational Medicine

The unique regulation and functions of type III interferons in antiviral immunity

(2015) Charlotte Odendall et al.   Current Opinion in Virology

Leukocyte-Derived IFN-α/β and Epithelial IFN-λ Constitute a Compartmentalized Mucosal Defense System that Restricts Enteric Virus Infections

(2015) Tanel Mahlakõiv et al.   PLoS Pathogens

The Virome in Mammalian Physiology and Disease

(2014) Herbert W. Virgin   CELL

Advances in Norovirus Biology

(2014) Stephanie M. Karst et al.   Cell Host & Microbe

A randomized phase 2b study of peginterferon lambda-1a for the treatment of chronic HCV infection

(2014) Andrew J. Muir et al.   JOURNAL OF HEPATOLOGY

An Important Role for Type III Interferon (IFN- /IL-28) in TLR-Induced Antiviral Activity

(2014) N. Ank et al.   JOURNAL OF IMMUNOLOGY

Interferon lambda 1–3 expression in infants hospitalized for RSV or HRV associated bronchiolitis

(2014) Carla Selvaggi et al.   JOURNAL OF INFECTION

Impact and Regulation of Lambda Interferon Response in Human Metapneumovirus Infection

(2014) Ma. Del Rocío Baños-Lara et al.   JOURNAL OF VIROLOGY

An enteric virus can replace the beneficial function of commensal bacteria

(2014) Elisabeth Kernbauer et al.   NATURE

Diverse intracellular pathogens activate type III interferon expression from peroxisomes

(2014) Charlotte Odendall et al.   NATURE IMMUNOLOGY

Human but Not Mouse Hepatocytes Respond to Interferon-Lambda In Vivo

(2014) Pascale Hermant et al.   PLoS One

Commensal microbes and interferon-  determine persistence of enteric murine norovirus infection

(2014) M. T. Baldridge et al.   SCIENCE

Interferon-  cures persistent murine norovirus infection in the absence of adaptive immunity

(2014) T. J. Nice et al.   SCIENCE

Pathogenic potential of interferon αβ in acute influenza infection

(2014) Sophia Davidson et al.   Nature Communications

Epigenetic Reprogramming of the Type III Interferon Response Potentiates Antiviral Activity and Suppresses Tumor Growth

(2014) Siyuan Ding et al.   PLOS BIOLOGY

Regulation of interferon lambda-1 (IFNL1/IFN-λ1/IL-29) expression in human colon epithelial cells

(2013) Adam Swider et al.   CYTOKINE

Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus

(2013) Nikolaus Jilg et al.   HEPATOLOGY

Dynamic expression profiling of type I and type III interferon-stimulated hepatocytes reveals a stable hierarchy of gene expression

(2013) Christopher R. Bolen et al.   HEPATOLOGY

Type I and Type III Interferons Drive Redundant Amplification Loops to Induce a Transcriptional Signature in Influenza-Infected Airway Epithelia

(2013) Stefania Crotta et al.   PLoS Pathogens

HCV Infection Induces a Unique Hepatic Innate Immune Response Associated With Robust Production of Type III Interferons

(2012) Emmanuel Thomas et al.   GASTROENTEROLOGY

IL-29 is the dominant type III interferon produced by hepatocytes during acute hepatitis C virus infection

(2012) Heiyoung Park et al.   HEPATOLOGY

Expression profiles of human interferon-alpha and interferon-lambda subtypes are ligand- and cell-dependent

(2012) Philippa Hillyer et al.   IMMUNOLOGY AND CELL BIOLOGY

Combined action of type I and type III interferon restricts initial replication of severe acute respiratory syndrome coronavirus in the lung but fails to inhibit systemic virus spread

(2012) T. Mahlakoiv et al.   JOURNAL OF GENERAL VIROLOGY

Protruding Domain of Capsid Protein Is Necessary and Sufficient To Determine Murine Norovirus Replication and Pathogenesis In Vivo

(2012) D. W. Strong et al.   JOURNAL OF VIROLOGY

A Single-Amino-Acid Change in Murine Norovirus NS1/2 Is Sufficient for Colonic Tropism and Persistence

(2012) T. J. Nice et al.   JOURNAL OF VIROLOGY

IFN-λs

(2011) Sergei V Kotenko   CURRENT OPINION IN IMMUNOLOGY

IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease

(2011) Ourania Koltsida et al.   EMBO Molecular Medicine

Hepatitis C virus induces interferon-λ and interferon-stimulated genes in primary liver cultures

(2011) Svetlana Marukian et al.   HEPATOLOGY

IFN-  determines the intestinal epithelial antiviral host defense

(2011) J. Pott et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type-III interferon, not type-I, is the predominant interferon induced by respiratory viruses in nasal epithelial cells

(2011) Tamaki Okabayashi et al.   VIRUS RESEARCH

Phase 1b study of pegylated interferon lambda 1 with or without ribavirin in patients with chronic genotype 1 hepatitis C virus infection

(2010) Andrew J. Muir et al.   HEPATOLOGY

Type I interferon: friend or foe?

(2010) Giorgio Trinchieri   JOURNAL OF EXPERIMENTAL MEDICINE

Interferon-λ in the Immune Response to Hepatitis B Virus and Hepatitis C Virus

(2010) Nicole E. Pagliaccetti et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections

(2010) M. Mordstein et al.   JOURNAL OF VIROLOGY

Expression of Type III Interferon (IFN) in the Vaginal Mucosa Is Mediated Primarily by Dendritic Cells and Displays Stronger Dependence on NF- B than Type I IFNs

(2010) M. B. Iversen et al.   JOURNAL OF VIROLOGY

Despite IFN-λ receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines

(2009) K Witte et al.   GENES AND IMMUNITY

Lambda Interferon Inhibits Human Immunodeficiency Virus Type 1 Infection of Macrophages

(2009) W. Hou et al.   JOURNAL OF VIROLOGY

JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin

(2009) Mark A. Dawson et al.   NATURE

Antibody Is Critical for the Clearance of Murine Norovirus Infection

(2008) K. A. Chachu et al.   JOURNAL OF VIROLOGY

Role of Interferon in Homologous and Heterologous Rotavirus Infection in the Intestines and Extraintestinal Organs of Suckling Mice

(2008) N. Feng et al.   JOURNAL OF VIROLOGY

Immune Mechanisms Responsible for Vaccination against and Clearance of Mucosal and Lymphatic Norovirus Infection

(2008) Karen A. Chachu et al.   PLoS Pathogens

IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

(2008) Caroline Sommereyns et al.   PLoS Pathogens