COVID-19 and emerging viral infections: The case for interferon lambda

Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus

(2020) Rishi R. Goel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

COVID-19: consider cytokine storm syndromes and immunosuppression

(2020) Puja Mehta et al.   LANCET

Interferon Lambda Inhibits Bacterial Uptake During Influenza Super-Infection

(2019) Helen E. Rich et al.   INFECTION AND IMMUNITY

Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and Type III Interferons

(2019) Adriana Forero et al.   IMMUNITY

Type III interferons: Balancing tissue tolerance and resistance to pathogen invasion

(2019) Achille Broggi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission

(2018) Jonas Klinkhammer et al.   eLife

Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness

(2017) Ioanna E. Galani et al.   IMMUNITY

IFNλ is a potent anti‐influenza therapeutic without the inflammatory side effects of IFNα treatment

(2016) Sophia Davidson et al.   EMBO Molecular Medicine

Lambda Interferon Restructures the Nasal Microbiome and Increases Susceptibility to Staphylococcus aureus Superinfection

(2016) Paul J. Planet et al.   mBio

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production

(2015) Katrina Blazek et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disease-Promoting Effects of Type I Interferons in Viral, Bacterial, and Coinfections

(2015) Sophia Davidson et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

A randomized phase 2b study of peginterferon lambda-1a for the treatment of chronic HCV infection

(2014) Andrew J. Muir et al.   JOURNAL OF HEPATOLOGY

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus

(2013) Ludmila Prokunina-Olsson et al.   NATURE GENETICS

Type I and Type III Interferons Drive Redundant Amplification Loops to Induce a Transcriptional Signature in Influenza-Infected Airway Epithelia

(2013) Stefania Crotta et al.   PLoS Pathogens