Antiviral interferon response at single-cell resolution

Mathematical modeling of within-host Zika virus dynamics

(2018) Katharine Best et al.   IMMUNOLOGICAL REVIEWS

A Tunable Diffusion-Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell-to-Cell Communication in the Immune System

(2017) Alon Oyler-Yaniv et al.   IMMUNITY

Single-cell analysis of early antiviral gene expression reveals a determinant of stochastic IFNB1 expression

(2017) Sultan Doğanay et al.   Integrative Biology

Quantitative profiling of innate immune activation by viral infection in single cells

(2017) Andrea C. Timm et al.   Integrative Biology

Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation

(2017) Jennifer Oyler-Yaniv et al.   MOLECULAR CELL

Absolute Ligand Discrimination by Dimeric Signaling Receptors

(2016) Sepehr Fathi et al.   BIOPHYSICAL JOURNAL

Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling

(2016) Alesha Grant et al.   Cell Host & Microbe

Innate immune evasion strategies of DNA and RNA viruses

(2016) Dia C Beachboard et al.   CURRENT OPINION IN MICROBIOLOGY

Multiscale modeling of virus replication and spread

(2016) Peter Kumberger et al.   FEBS LETTERS

Tools for Single-Cell Kinetic Analysis of Virus-Host Interactions

(2016) Jay W. Warrick et al.   PLoS One

Structural basis for m7G recognition and 2′-O-methyl discrimination in capped RNAs by the innate immune receptor RIG-I

(2016) Swapnil C. Devarkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multi-scale model for hepatitis C viral load kinetics under treatment with direct acting antivirals

(2016) Diana Clausznitzer et al.   VIRUS RESEARCH

Modeling Viral Spread

(2016) Frederik Graw et al.   Annual Review of Virology

Individual T Helper Cells Have a Quantitative Cytokine Memory

(2015) Caroline Helmstetter et al.   IMMUNITY

Targeting Innate Immunity for Antiviral Therapy through Small Molecule Agonists of the RLR Pathway

(2015) Sowmya Pattabhi et al.   JOURNAL OF VIROLOGY

Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection

(2015) Sonali Patil et al.   Science Signaling

Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection

(2015) Frank S. Heldt et al.   Nature Communications

Live Cell Analysis and Mathematical Modeling Identify Determinants of Attenuation of Dengue Virus 2’-O-Methylation Mutant

(2015) Bianca Schmid et al.   PLoS Pathogens

Single-cell analysis shows that paracrine signaling by first responder cells shapes the interferon-β response to viral infection

(2015) Sonali Patil et al.   Science Signaling

Flaviviridae Replication Organelles: Oh, What a Tangled Web We Weave

(2015) David Paul et al.   Annual Review of Virology

Interferon-Stimulated Genes: A Complex Web of Host Defenses

(2014) William M. Schneider et al.   Annual Review of Immunology

Viral kinetic modeling: state of the art

(2014) Laetitia Canini et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

(2014) Alex K. Shalek et al.   NATURE

Uncoupling of the dynamics of host–pathogen interaction uncovers new mechanisms of viral interferon antagonism at the single-cell level

(2014) Ulfert Rand et al.   NUCLEIC ACIDS RESEARCH

Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins

(2013) Yazan M. Abbas et al.   NATURE

Replication Vesicles are Load- and Choke-Points in the Hepatitis C Virus Lifecycle

(2013) Marco Binder et al.   PLoS Pathogens

Dengue Virus Co-opts UBR4 to Degrade STAT2 and Antagonize Type I Interferon Signaling

(2013) Juliet Morrison et al.   PLoS Pathogens

Sequestration by IFIT1 Impairs Translation of 2′O-unmethylated Capped RNA

(2013) Matthias Habjan et al.   PLoS Pathogens

Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response

(2012) Ulfert Rand et al.   Molecular Systems Biology

Intrinsic antiviral immunity

(2012) Nan Yan et al.   NATURE IMMUNOLOGY

Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution

(2012) A. Sen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stochastic Expression of the Interferon-β Gene

(2012) Mingwei Zhao et al.   PLOS BIOLOGY

Stochastic Receptor Expression Determines Cell Fate upon Interferon Treatment

(2011) D. Levin et al.   MOLECULAR AND CELLULAR BIOLOGY

Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range

(2011) J. Bachmann et al.   Molecular Systems Biology

Ribose 2′-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5

(2011) Roland Züst et al.   NATURE IMMUNOLOGY

IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

(2011) Andreas Pichlmair et al.   NATURE IMMUNOLOGY

Interferon-stimulated genes and their antiviral effector functions

(2011) John W Schoggins et al.   Current Opinion in Virology

Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression

(2010) Luca Mariani et al.   Molecular Systems Biology

2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

(2010) Stephane Daffis et al.   NATURE

Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system

(2010) Christopher T Jones et al.   NATURE BIOTECHNOLOGY

Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments

(2010) D. Busse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Co-ordinated Role of TLR3, RIG-I and MDA5 in the Innate Response to Rhinovirus in Bronchial Epithelium

(2010) Louise Slater et al.   PLoS Pathogens

Dengue Virus NS5 Inhibits Interferon‐α Signaling by Blocking Signal Transducer and Activator of Transcription 2 Phosphorylation

(2009) Michela Mazzon et al.   JOURNAL OF INFECTIOUS DISEASES

NS5 of Dengue Virus Mediates STAT2 Binding and Degradation

(2009) J. Ashour et al.   JOURNAL OF VIROLOGY

Bistability, Epigenetics, and Bet-Hedging in Bacteria

(2008) Jan-Willem Veening et al.   Annual Review of Microbiology

Virus Infection Induces NF-κB-Dependent Interchromosomal Associations Mediating Monoallelic IFN-β Gene Expression

(2008) Effie Apostolou et al.   CELL