HMGB1 in Radiotherapy: A Two Headed Signal Regulating Tumor Radiosensitivity and Immunity

Graphene Oxide Nanosheets for Localized Hyperthermia—Physicochemical Characterization, Biocompatibility, and Induction of Tumor Cell Death

(2020) Malgorzata J. Podolska et al.   Cells

Cancer-cell-secreted CXCL11 promoted CD8+ T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC

(2019) Qun Gao et al.   Journal for ImmunoTherapy of Cancer

Tumor-derived exosomal HMGB1 promotes esophageal squamous cell carcinoma progression through inducing PD1+ TAM expansion

(2019) Bin Li et al.   Oncogenesis

High mobility group box 1 promotes radioresistance in esophageal squamous cell carcinoma cell lines by modulating autophagy

(2019) Hongbing Ma et al.   Cell Death & Disease

IL-33/regulatory T cell axis triggers the development of a tumor-promoting immune environment in chronic inflammation

(2019) Amir H. Ameri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Realizing the Clinical Potential of Immunogenic Cell Death in Cancer Chemotherapy and Radiotherapy

(2019) Bernardo Rapoport et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cytoplasmic HMGB1 and HMGB1-Beclin1 complex are increased in radioresistant oral squamous cell carcinoma

(2019) Hyun Jin Min et al.   BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY

The immune mediated role of extracellular HMGB1 in a heterotopic model of bladder cancer radioresistance

(2019) Mina Ayoub et al.   Scientific Reports

HMGB1: A generalist in immunity

(2019) Jingjing Zhao et al.   CURRENT GENE THERAPY

Tumor Microenvironment as A “Game Changer” in Cancer Radiotherapy

(2019) Magdalena Jarosz-Biej et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HMGB1-mediated autophagy regulates sodium/iodide symporter protein degradation in thyroid cancer cells

(2019) Wenwen Chai et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Johnny on the Spot-Chronic Inflammation Is Driven by HMGB1

(2019) Carolina M. Gorgulho et al.   Frontiers in Immunology

Cancer Stem Cells and Radioresistance: DNA Repair and Beyond

(2019) Alexander Schulz et al.   Cancers

Survival of the fittest: how myeloid-derived suppressor cells survive in the inhospitable tumor microenvironment

(2019) Suzanne Ostrand-Rosenberg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Hypoxia enhances IL-10-producing B cell generation through upregulating high-mobility group B1 on tumor cell-released autophagosomes

(2019) Yue Zhang et al.   IMMUNOLOGY LETTERS

Promoter methylation of SEPT9 as a potential biomarker for early detection of cervical cancer and its overexpression predicts radioresistance

(2019) Xinlin Jiao et al.   Clinical Epigenetics

Exosomal and extracellular HMGB1 have opposite effects on SASH1 expression in rat astrocytes and glioma C6 cells

(2019) Chao Ma et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interactions of high mobility group box protein 1 (HMGB1) with nucleic acids: Implications in DNA repair and immune responses

(2019) Pooja Mandke et al.   DNA REPAIR

A translational concept of immuno-radiobiology

(2019) Bodo E. Lippitz et al.   RADIOTHERAPY AND ONCOLOGY

Tumor Microenvironment: A Metabolic Player that Shapes the Immune Response

(2019) Shamir Cassim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting RAGE Signaling in Inflammatory Disease

(2018) Barry I. Hudson et al.   Annual Review of Medicine

DAMP-TLR-cytokine axis dictates the fate of tumor

(2018) Ashok Patidar et al.   CYTOKINE

HMGB1 contributes to the irradiation-induced endothelial barrier injury through receptor for advanced glycation endproducts (RAGE)

(2018) Haihong Zhou et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Radiotherapy-induced cell death activates paracrine HMGB1-TLR2 signaling and accelerates pancreatic carcinoma metastasis

(2018) Xuelian Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

High-mobility group box 1 protein modulated Proliferation and Radioresistance in Esophageal Squamous Cell Carcinoma

(2018) Xiaoke Di et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

HMGB1 released by irradiated tumor cells promotes living tumor cell proliferation via paracrine effect

(2018) Sijia He et al.   Cell Death & Disease

Combination Treatment of Stereotactic Body Radiation Therapy and Immature Dendritic Cell Vaccination for Augmentation of Local and Systemic Effects

(2018) Chul Won Choi et al.   Cancer Research and Treatment

Immunogenic cell death in anticancer chemotherapy and its impact on clinical studies

(2018) Qiang Wang et al.   CANCER LETTERS

A cycle involving HMGB1, IFN-γ and dendritic cells plays a putative role in anti-tumor immunity

(2018) Qun Gao et al.   CELLULAR IMMUNOLOGY

In Vivo Irradiation of Mice Induces Activation of Dendritic Cells

(2018) Eszter Persa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HMGB1/RAGE axis mediates the apoptosis, invasion, autophagy, and angiogenesis of the renal cell carcinoma

(2018) Cun-Zao Wu et al.   OncoTargets and Therapy

Radiosensitization of esophageal carcinoma cells by knockdown of HMGB1 expression

(2018) Xueyuan Zhang et al.   ONCOLOGY REPORTS

The progression of HMGB1-induced autophagy in cancer biology

(2018) Tianwei Xu et al.   OncoTargets and Therapy

Secretory High-Mobility Group Box 1 Protein Affects Regulatory T Cell Differentiation in Neuroblastoma Microenvironment In Vitro

(2018) Thitinee Vanichapol et al.   Journal of Oncology

Cell death and immunity in cancer: From danger signals to mimicry of pathogen defense responses

(2017) Abhishek D. Garg et al.   IMMUNOLOGICAL REVIEWS

Immunomodulation by ionizing radiation-impact for design of radio-immunotherapies and for treatment of inflammatory diseases

(2017) Benjamin Frey et al.   IMMUNOLOGICAL REVIEWS

Role of autophagy in regulating the radiosensitivity of tumor cells

(2017) Yong Xin et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Myeloid-derived suppressor cells: Important contributors to tumor progression and metastasis

(2017) Elham Safarzadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

HMGB1 promotes myeloid-derived suppressor cells and renal cell carcinoma immune escape

(2017) Jinfeng Li et al.   Oncotarget

Stereotactic Radiotherapy Increases Functionally Suppressive Regulatory T Cells in the Tumor Microenvironment

(2017) Yuki Muroyama et al.   Cancer Immunology Research

High-mobility group protein box1 expression correlates with peritumoral macrophage infiltration and unfavorable prognosis in patients with hepatocellular carcinoma and cirrhosis

(2016) Qiang-Bo Zhang et al.   BMC CANCER

Radiotherapy combination opportunities leveraging immunity for the next oncology practice

(2016) Fernanda G. Herrera et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Macrophage migration inhibitory factor promotes breast cancer metastasis via activation of HMGB1/TLR4/NF kappa B axis

(2016) Wei Lv et al.   CANCER LETTERS

Pivotal role of high-mobility group box 1 (HMGB1) signaling pathways in glioma development and progression

(2016) Efthalia Angelopoulou et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

High-mobility group box 1 is overexpressed in cervical carcinoma and promotes cell invasion and migration in vitro

(2016) Xiaoao Pang et al.   ONCOLOGY REPORTS

HMGB1 as biomarker and drug target

(2016) Emilie Venereau et al.   PHARMACOLOGICAL RESEARCH

Until Death Do Us Part: Necrosis and Oxidation Promote the Tumor Microenvironment

(2016) Ramin Lotfi et al.   TRANSFUSION MEDICINE AND HEMOTHERAPY

Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation

(2016) Lisa Deloch et al.   Frontiers in Oncology

Immune-priming of the Tumor Microenvironment by Radiotherapy

(2015) Vafa Shahabi et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

High-mobility group Box 1: A novel inducer of the epithelial–mesenchymal transition in colorectal carcinoma

(2015) Lingyin Zhu et al.   CANCER LETTERS

Molecular Pathways: Overcoming Radiation Resistance by Targeting DNA Damage Response Pathways

(2015) M. A. Morgan et al.   CLINICAL CANCER RESEARCH

Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation

(2015) Xiaorong Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Carbon-ion beams induce production of an immune mediator protein, high mobility group box 1, at levels comparable with X-ray irradiation

(2015) Y. Yoshimoto et al.   JOURNAL OF RADIATION RESEARCH

The Role of HMGB1 in Radioresistance of Bladder Cancer

(2015) S. Shrivastava et al.   MOLECULAR CANCER THERAPEUTICS

In situ vaccination: Cancer immunotherapy both personalized and off-the-shelf

(2015) Linda Hammerich et al.   Molecular Oncology

Radiotherapy and Immunogenic Cell Death

(2015) Encouse B. Golden et al.   SEMINARS IN RADIATION ONCOLOGY

Cancer nanomedicine: from targeted delivery to combination therapy

(2015) Xiaoyang Xu et al.   TRENDS IN MOLECULAR MEDICINE

HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism

(2015) Armando Rojas et al.   TUMOR BIOLOGY

HMGB1 overexpression correlates with poor prognosis in early-stage squamous cervical cancer

(2015) Yirong Xu et al.   TUMOR BIOLOGY

mir-129-5p Attenuates Irradiation-Induced Autophagy and Decreases Radioresistance of Breast Cancer Cells by Targeting HMGB1

(2015) Jing Luo et al.   MEDICAL SCIENCE MONITOR

Introduction to the Review Series Autophagy in Higher Eukaryotes– A matter of survival or death

(2014) Ameeta Kelekar   Autophagy

HMGB1 Enhances Immune Suppression by Facilitating the Differentiation and Suppressive Activity of Myeloid-Derived Suppressor Cells

(2014) K. H. Parker et al.   CANCER RESEARCH

Downregulation of high mobility group box 1 modulates telomere homeostasis and increases the radiosensitivity of human breast cancer cells

(2014) SHAOBO KE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Maturing Dendritic Cells Depend on RAGE for In Vivo Homing to Lymph Nodes

(2014) A. A. Manfredi et al.   JOURNAL OF IMMUNOLOGY

Parkin and PINK1: much more than mitophagy

(2014) Leslie A. Scarffe et al.   TRENDS IN NEUROSCIENCES

The Importance of Autophagy Regulation in Breast Cancer Development and Treatment

(2014) Joanna Magdalena Zarzynska   Biomed Research International

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

Radiation for Awakening the Dormant Immune System, a Promising Challenge to be Explored

(2014) Luis de la Cruz-Merino et al.   Frontiers in Immunology

Radiation-induced survival responses promote immunogenic modulation to enhance immunotherapy in combinatorial regimens

(2014) Sofia R Gameiro et al.   OncoImmunology

Alarmins released during local antitumor treatments play an essential role in enhancing tumor growth inhibition at treated and non-treated sites via a derivative of CCL3

(2014) Shiro Kanegasaki et al.   OncoImmunology

Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death

(2014) Encouse B Golden et al.   OncoImmunology

Biological Consequences of Radiation-induced DNA Damage: Relevance to Radiotherapy

(2013) M.E. Lomax et al.   CLINICAL ONCOLOGY

The noninflammatory role of high mobility group box 1/toll-like receptor 2 axis in the self-renewal of mammary cancer stem cells

(2013) Laura Conti et al.   FASEB JOURNAL

Responses to ionizing radiation mediated by inflammatory mechanisms

(2013) Debayan Mukherjee et al.   JOURNAL OF PATHOLOGY

The activation of HMGB1 as a progression factor on inflammation response in normal human bronchial epithelial cells through RAGE/JNK/NF-κB pathway

(2013) Xiaojin Wu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Radiation as an Immune Modulator

(2013) Byron Burnette et al.   SEMINARS IN RADIATION ONCOLOGY

Immunogenic tumor cell death induced by chemoradiotherapy: molecular mechanisms and a clinical translation

(2013) K Kono et al.   Cell Death & Disease

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Tissue Damage-Associated "Danger Signals" Influence T-cell Responses That Promote the Progression of Preneoplasia to Cancer

(2012) Y. He et al.   CANCER RESEARCH

p53/HMGB1 Complexes Regulate Autophagy and Apoptosis

(2012) K. M. Livesey et al.   CANCER RESEARCH

Immunogenic Tumor Cell Death Induced by Chemoradiotherapy in Patients with Esophageal Squamous Cell Carcinoma

(2012) Yoshiyuki Suzuki et al.   CANCER RESEARCH

Radiation-Induced Stress Proteins - the Role of Heat Shock Proteins (HSP) in Anti- Tumor Responses

(2012) T.E. Schmid et al.   CURRENT MEDICINAL CHEMISTRY

Inhibition of high-mobility group box 1 as therapeutic option in autoimmune disease

(2012) Fleur Schaper et al.   CURRENT OPINION IN RHEUMATOLOGY

HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells

(2012) Clarissa Anni Wild et al.   INTERNATIONAL IMMUNOLOGY

HMGB1 is overexpressed in tumor cells and promotes activity of regulatory T cells in patients with head and neck cancer

(2012) Clarissa A. Wild et al.   ORAL ONCOLOGY

Role of T lymphocytes in tumor response to radiotherapy

(2012) Sandra Demaria et al.   Frontiers in Oncology

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

High Mobility Group Box 1 (HMGB1) Activates an Autophagic Response to Oxidative Stress

(2011) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control

(2011) Daolin Tang et al.   Cell Metabolism

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Knockdown of HMGB1 in Tumor Cells Attenuates Their Ability To Induce Regulatory T Cells and Uncovers Naturally Acquired CD8 T Cell-Dependent Antitumor Immunity

(2011) Z. Liu et al.   JOURNAL OF IMMUNOLOGY

Radiation combined with hyperthermia induces HSP70-dependent maturation of dendritic cells and release of pro-inflammatory cytokines by dendritic cells and macrophages

(2011) Petra Schildkopf et al.   RADIOTHERAPY AND ONCOLOGY

Autophagy contributes to resistance of tumor cells to ionizing radiation

(2011) Hassan Chaachouay et al.   RADIOTHERAPY AND ONCOLOGY

Autophagy inhibition contributes to radiation sensitization of esophageal squamous carcinoma cells

(2010) Y. S. Chen et al.   DISEASES OF THE ESOPHAGUS

Radiation Enhances Regulatory T Cell Representation

(2010) Evelyn L. Kachikwu et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Endogenous HMGB1 regulates autophagy

(2010) Daolin Tang et al.   JOURNAL OF CELL BIOLOGY

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

Links between Innate Immunity and Normal Tissue Radiobiology

(2010) Dörthe Schaue et al.   RADIATION RESEARCH

Immunogenic cell death, DAMPs and anticancer therapeutics: An emerging amalgamation

(2009) Abhishek D. Garg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Fueling inflammation at tumor microenvironment: the role of multiligand/rage axis

(2009) A. Rojas et al.   CARCINOGENESIS

Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks

(2009) Sabine S. Lange et al.   DNA REPAIR

The induction of autophagy by γ-radiation contributes to the radioresistance of glioma stem cells

(2009) Stephanie L. Lomonaco et al.   INTERNATIONAL JOURNAL OF CANCER

HMGB1 loves company

(2009) Marco E. Bianchi   JOURNAL OF LEUKOCYTE BIOLOGY

HMGB1: The jack-of-all-trades protein is a master DNA repair mechanic

(2009) Sabine S. Lange et al.   MOLECULAR CARCINOGENESIS

HMGB1: a two-headed signal regulating tumor progression and immunity

(2008) Lara Campana et al.   CURRENT OPINION IN IMMUNOLOGY

High mobility group box chromosomal protein 1 acts as a proliferation signal for activated T lymphocytes

(2008) Erik Sundberg et al.   IMMUNOBIOLOGY

RAGE signaling sustains inflammation and promotes tumor development

(2008) Christoffer Gebhardt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ATM Signaling Facilitates Repair of DNA Double-Strand Breaks Associated with Heterochromatin

(2008) Aaron A. Goodarzi et al.   MOLECULAR CELL

High mobility group protein B1 enhances DNA repair and chromatin modification after DNA damage

(2008) S. S. Lange et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA