Article
Cell Biology
Jiacheng Li, Yu Xia, Biying Sun, Nanbei Zheng, Yang Li, Xuehan Pang, Fan Yang, Xingwang Zhao, Zhiwu Ji, Haitao Yu, Fujun Chen, Xuemei Zhang, Bin Zhao, Jiaqi Jin, Shifeng Yang, Zhuoxin Cheng
Summary: Hypoxia in gastric cancer triggers the formation of neutrophil extracellular traps (NETs) through the HMGB1/TLR4/p38 MAPK pathway. NETs promote gastric cancer cell invasion and migration, accelerating tumor growth. Targeting NETs or the HMGB1/TLR4/p38 MAPK pathway may be a potential therapeutic strategy for inhibiting gastric cancer progression.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Multidisciplinary Sciences
Surashri Shinde-Jadhav, Jose Joao Mansure, Roni F. Rayes, Gautier Marcq, Mina Ayoub, Rodrigo Skowronski, Ronald Kool, France Bourdeau, Fadi Brimo, Jonathan Spicer, Wassim Kassouf
Summary: Radioresistance in bladder cancer treatment is linked to the recruitment of neutrophil extracellular traps (NETs) to the tumor immune microenvironment post-radiation therapy, as demonstrated in a mouse model. Inhibition of NETs can improve radiation response, suggesting NETs as a potential therapeutic target to enhance radiation efficacy.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Alicia S. Eustes, Sanjana Dayal
Summary: This review article provides information on the important roles of platelet-derived extracellular vesicles (PEVs) in hemostasis and thrombosis, including their production mechanisms, characteristics, cellular interactions, and pathological role in diseases. The article also highlights the mechanisms through which PEVs can activate parent cells in a feedback loop.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Lixia Wang, Chuanlai Yang, Man Chu, Zhi-wei Wang, Boxin Xue
Summary: The study investigated the molecular mechanisms underlying radioresistance in bladder cancer, revealing elevated Cdc20 expression in IR cells and its role in governing IR-mediated EMT by regulating FoxO1 degradation. Therefore, inhibiting Cdc20 or activating FoxO1 may be potential strategies to overcome radioresistance in bladder cancer.
Article
Biochemistry & Molecular Biology
Carlos J. Ortiz-Bonilla, Taylor P. Uccello, Scott A. Gerber, Edith M. Lord, Edward M. Messing, Yi-Fen Lee
Summary: Tumor-derived extracellular vesicles (TEVs) play important roles in mediating immune responses and have the potential to modulate antigen-specific CD8(+) T-cell responses. This study demonstrated that immunogenic extracellular vesicles derived from bladder cancer cells can prevent tumor growth and elicit cytotoxic CD8(+) T-cell-mediated protection. These findings support the potential use of TEVs in personalized medicine and the development of adjuvant therapies to prevent disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Khalid Otmani, Redouane Rouas, Philippe Lewalle
Summary: Currently, microRNAs play a central role in tumorigenesis and have opened up a new avenue for understanding the communication between immune and tumor cells. The transfer of onco-miRs from tumor cells to cells in the tumor microenvironment through exosomes is an important aspect of this dialogue. This review discusses recent advances in the role of oncomiRs in promoting cancer development and modulating the immune response in the tumor immune microenvironment. MicroRNAs (miRNAs) are noncoding RNA molecules that regulate gene expression and can enhance or inhibit cancer development. They are categorized as oncogenes (oncomiRs) or tumor suppressor (TS) miRNAs, depending on whether they promote or suppress tumor growth. MiRNAs not only regulate pathways in cancer cells but also in the cells surrounding the tumor. It has been shown that miRNAs can be transferred between different cell types, with exosomes serving as the primary carriers. Communication between the tumor and its surrounding stromal cells through exosomes and miRNAs is crucial for cancer progression and immune suppression. Understanding the role of oncomiRs in immune suppression will aid in the development of miRNAs as biomarkers for impaired antitumor immune function and potential targets for immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Clara Garcia-Vallicrosa, Juan M. Falcon-Perez, Felix Royo
Summary: The human CERS2 gene encodes a protein called CERS2, which has been found to have antitumor effects in various types of cancer, but promotes tumor growth in adenocarcinoma. This review focuses on the influence of CERS2 in bladder cancer, including its structure, activity, and the miRNAs that regulate its expression. Mechanistically, CERS2 may act as an antitumor protein through the production of long-chain ceramides, interaction with vacuolar ATPase, and inhibition of mitochondrial fission. Additionally, the expression of CERS2 in bladder cancer and its association with disease progression are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Xiaohua Jie, William Pat Fong, Rui Zhou, Ye Zhao, Yingchao Zhao, Rui Meng, Sheng Zhang, Xiaorong Dong, Tao Zhang, Kunyu Yang, Gang Wu, Shuangbing Xu
Summary: This study found that overexpression of KDM4C is associated with poor prognosis in lung cancer patients; genetic or pharmacological inhibition of KDM4C can reduce tumorigenesis and radioresistance in lung cancer; USP9X-mediated deubiquitination of KDM4C activates TGF-beta 2/Smad signaling pathway to promote radioresistance in lung cancer.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Oncology
Lei Zhang, Yuqing Li, Lingli Zhou, Houhong Zhou, Liefu Ye, Tong Ou, Huaishan Hong, Shiwen Zheng, Ziyu Zhou, Kang Wu, Zeqin Yan, Jean Paul Thiery, Jun Cui, Song Wu
Summary: YTHDF2 is upregulated in bladder cancer and promotes tumor growth by inhibiting RIG-I-mediated immune signaling, highlighting the significance of m(6)A modifications in bladder cancer and providing therapeutic opportunities.
Article
Oncology
Hajar El Ahanidi, Meryem El Azzouzi, Chaimae Hafidi Alaoui, Mohammed Tetou, Mounia Bensaid, Imane Chaoui, Laila Benbacer, Ilias Hassan, Mohamed Oukabli, Katarzyna Michaud, Ahmed Ameur, Abderrahmane Al Bouzidi, Mohammed El Mzibri, Camilla Jandus, Mohammed Attaleb
Summary: The loop involving TERT, PD-1 ligands, and miR-138-5p in bladder cancer may serve as a promising therapeutic target and also a useful biomarker for improved diagnosis and patients' stratification.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yanhua Fang, Shanshan Liang, Jianong Gao, Zhe Wang, Cheng Li, Ruoyu Wang, Weiting Yu
Summary: This study compares the tumor biological behaviors of nasopharyngeal carcinoma (NPC) cells in 2D and 3D systems and investigates the correlation between radioresistance and extracellular matrix (ECM) stiffness. The results show that NPC cells cultured in 3D systems have a morphology more similar to in vivo tumor cells and exhibit stronger radioresistance. Additionally, NPC cells cultured in softer ECM systems show significant resistance to ionizing radiation.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Zhao Zhang, Yongbo Yu, Zhilei Zhang, Dan Li, Zhijuan Liang, Liping Wang, Yuanbin Chen, Ye Liang, Haitao Niu
Summary: This study revealed a novel mechanism for the role of CXCL12 in P62-mediated PDL1 autophagic regulation. Combined application of CXCL12 receptor blocker and PD1/PDL1 blocker can more effectively inhibit PDL1 expression and enhance antitumor immune response. Targeting CAFs-derived CXCL12 may provide an effective strategy for immunotherapy in bladder cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Review
Medicine, Research & Experimental
Xiangqi Chen, Qian Liu, Enqing Wu, Zhiyuan Ma, Biguang Tuo, Shuji Terai, Taolang Li, Xuemei Liu
Summary: HMGB1 plays an important role in digestive cancer by participating in pathways of digestive tissue injury and tumor development, and by promoting antitumor immune response. Therefore, targeted therapies against HMGB1 are of great significance in the treatment of digestive cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Kevin Chih-Yang Huang, Tao-Wei Ke, Jia-Yi Chen, Wei-Ze Hong, Shu-Fen Chiang, Chia-Ying Lai, Tsung-Wei Chen, Pei-Chen Yang, Liang-Chi Chen, Ji-An Liang, William Tzu-Liang Chen, K. S. Clifford Chao
Summary: This study found that patients with colorectal cancer who carry the TLR1-N248S polymorphism may have a higher risk of distant metastasis and poorer response to adjuvant chemotherapy. Defective TLR1 affects dendritic cell maturation and immune cell infiltration, while TLR1/2 agonists enhance the efficacy of chemotherapy and increase tumor-infiltrating immune cells.
SCIENTIFIC REPORTS
(2023)
Review
Biology
Pratik Thapa, Hong Jiang, Na Ding, Yanning Hao, Aziza Alshahrani, Qiou Wei
Summary: Peroxiredoxins (Prxs) are widely expressed antioxidant enzymes in human tissues, and they are also present in archaea, bacteria, and eukaryota. Prxs play a crucial role in defending against oxidative stress due to their abundant expression in different cellular organelles and high sensitivity to H2O2. They are upregulated in cancer cells and can function as tumor promoters in various cancers. This review aims to summarize recent discoveries regarding the roles of Prxs in common cancer types and highlight their potential significance in improving cancer therapeutics and patient survival.
Article
Oncology
Reem Albeesh, Guy-Anne Turgeon, Joanne Alfieri, Jose Joao Mansure, Lili Fu, Jocelyne Arseneau, Xing Zeng, Kris Jardon, Lucy Gilbert, Luis Souhami
GYNECOLOGIC ONCOLOGY
(2019)
Article
Immunology
Fernando Alvarez, Roman Istomine, Mitra Shourian, Nils Pavey, Tho Al-Fakar Al-Aubodah, Salman Qureshi, Jorg H. Fritz, Ciriaco A. Piccirillo
MUCOSAL IMMUNOLOGY
(2019)
Article
Oncology
Alexis Rompre-Brodeur, Surashri Shinde-Jadhav, Mina Ayoub, Ciriaco A. Piccirillo, Jan Seuntjens, Fadi Brimo, Jose Joao Mansure, Wassim Kassouf
MOLECULAR CANCER THERAPEUTICS
(2020)
Article
Urology & Nephrology
Madhuri Koti, David M. Berman, D. Robert Siemens, Dirk Lange, Edwin Wang, Paul Toren, Bernhard J. Eigl, Celine Hardy, Robert Purves, Vincent Fradet, Yves Fradet, Jose Mansure, Wassim Kassouf, Peter C. Black
CUAJ-CANADIAN UROLOGICAL ASSOCIATION JOURNAL
(2020)
Article
Oncology
Ronald Kool, Gautier Marcq, Adnan El-Achkar, Jose Joao Mansure, Marie Vanhuyse, Armen Aprikian, Simon Tanguay, Fabio L. Cury, Fadi Brimo, Luis Souhami, Wassim Kassouf
Summary: This retrospective study reviewed the significance of bladder biopsy in assessing treatment response post-RT for MIBC patients, indicating that routine biopsy may be warranted to evaluate treatment response and potentially benefit patients who require early surgical intervention. Further prospective studies are needed to confirm these findings.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Oncology
Gautier Marcq, Luis Souhami, Fabio L. Cury, Afsar Salimi, Armen Aprikian, Simon Tanguay, Marie Vanhuyse, Raghu Rajan, Fadi Brimo, Jose Joao Mansure, Wassim Kassouf
Summary: This study evaluated the safety and tolerability of atezolizumab in combination with trimodal therapy in patients with localized muscle invasive bladder cancer. The results suggest that concurrent administration of atezolizumab with concomitant hypofractionated radiation therapy and gemcitabine may lead to unacceptable gastrointestinal toxicity, highlighting the need for caution in its use with trimodal therapy for MIBC.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Article
Multidisciplinary Sciences
Surashri Shinde-Jadhav, Jose Joao Mansure, Roni F. Rayes, Gautier Marcq, Mina Ayoub, Rodrigo Skowronski, Ronald Kool, France Bourdeau, Fadi Brimo, Jonathan Spicer, Wassim Kassouf
Summary: Radioresistance in bladder cancer treatment is linked to the recruitment of neutrophil extracellular traps (NETs) to the tumor immune microenvironment post-radiation therapy, as demonstrated in a mouse model. Inhibition of NETs can improve radiation response, suggesting NETs as a potential therapeutic target to enhance radiation efficacy.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Jinsam Chang, Antoine Bouchard, Yasser Bouklouch, Vincent Panneton, Joanna Li, Nikoletta Diamantopoulos, Saba Mohammaei, Roman Istomine, Fernando Alvarez, Ciriaco A. Piccirillo, Woong-Kyun Suh
Summary: ICOS is expressed in activated T cells and has a positive role in the differentiation and function of effector T cells. It is also expressed in a subpopulation of regulatory T cells and contributes to their homeostasis, migration, and function. However, tissue-protective Treg populations do not heavily rely on ICOS costimulation. In inflammatory conditions, ICOS has a dual positive role in both effector and Treg cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Ronald Kool, Gautier Marcq, Surashri Shinde-Jadhav, Jose Joao Mansure, Ramy Saleh, Raghu Rajan, Armen Aprikian, Simon Tanguay, Fabio L. Cury, Fadi Brimo, Luis Souhami, Wassim Kassouf
Summary: This study analyzed the impact of serum lymphocyte-based biomarkers on patients with MIBC treated with trimodal therapy. It found that a high pre-NLR value was associated with a lower treatment response rate and poorer survival outcomes.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
Review
Immunology
Fernando Alvarez, Jorg H. Fritz, Ciriaco A. Piccirillo
FRONTIERS IN IMMUNOLOGY
(2019)