Modern Radiotherapy Concepts and the Impact of Radiation on Immune Activation

Lung cancer: the immune system and radiation

(2015) F. Mendes et al.   BRITISH JOURNAL OF BIOMEDICAL SCIENCE

Immune-modulating properties of ionizing radiation: rationale for the treatment of cancer by combination radiotherapy and immune checkpoint inhibitors

(2015) Anja Derer et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Contribution of the immune system to bystander and non-targeted effects of ionizing radiation

(2015) Franz Rödel et al.   CANCER LETTERS

Building immunity to cancer with radiation therapy

(2015) Suresh J. Haikerwal et al.   CANCER LETTERS

Stereotactic body radiation therapy and intensity modulated radiation therapy induce different plasmatic cytokine changes in non-small cell lung cancer patients: a pilot study

(2015) M. Trovo et al.   Clinical & Translational Oncology

Ablative Tumor Radiation Can Change the Tumor Immune Cell Microenvironment to Induce Durable Complete Remissions

(2015) A. Filatenkov et al.   CLINICAL CANCER RESEARCH

Genetic landscape of metastatic and recurrent head and neck squamous cell carcinoma

(2015) Matthew L. Hedberg et al.   JOURNAL OF CLINICAL INVESTIGATION

Radio-immunotherapy: the focused beam expands

(2015) Benjamin Frey et al.   LANCET ONCOLOGY

Local radiotherapy and granulocyte-macrophage colony-stimulating factor to generate abscopal responses in patients with metastatic solid tumours: a proof-of-principle trial

(2015) Encouse B Golden et al.   LANCET ONCOLOGY

Targeting the Mitotic Catastrophe Signaling Pathway in Cancer

(2015) Margaret M. Mc Gee   MEDIATORS OF INFLAMMATION

Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy

(2015) S Fulda et al.   ONCOGENE

The in vitro immunogenic potential of caspase-3 proficient breast cancer cells with basal low immunogenicity is increased by hypofractionated irradiation

(2015) Bernhard Kötter et al.   Radiation Oncology

Myeloid-Derived Cells in Tumors: Effects of Radiation

(2015) Ralph E. Vatner et al.   SEMINARS IN RADIATION ONCOLOGY

Radiotherapy and Immunogenic Cell Death

(2015) Encouse B. Golden et al.   SEMINARS IN RADIATION ONCOLOGY

Vorträge

(2015)   STRAHLENTHERAPIE UND ONKOLOGIE

Die stereotaktische Strahlentherapie unterstützt die Immunantwort

(2015) Esther G. C. Troost   STRAHLENTHERAPIE UND ONKOLOGIE

PD-1 Restrains Radiotherapy-Induced Abscopal Effect

(2015) S. S. Park et al.   Cancer Immunology Research

Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses – Pre-Clinical Evidence and Ongoing Clinical Applications

(2015) Anja Derer et al.   Frontiers in Immunology

Autophagy promotes radiation-induced senescence but inhibits bystander effects in human breast cancer cells

(2014) Yao-Huei Huang et al.   Autophagy

Acquired Resistance to Fractionated Radiotherapy Can Be Overcome by Concurrent PD-L1 Blockade

(2014) S. J. Dovedi et al.   CANCER RESEARCH

The Four Faces of Autophagy: Implications for Cancer Therapy

(2014) D. A. Gewirtz   CANCER RESEARCH

Low and moderate doses of ionizing radiation up to 2 Gy modulate transmigration and chemotaxis of activated macrophages, provoke an anti-inflammatory cytokine milieu, but do not impact upon viability and phagocytic function

(2014) R. Wunderlich et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Kill and spread the word: stimulation of antitumor immune responses in the context of radiotherapy

(2014) Udo S Gaipl et al.   Immunotherapy

Final Results of Local-Regional Control and Late Toxicity of RTOG 9003: A Randomized Trial of Altered Fractionation Radiation for Locally Advanced Head and Neck Cancer

(2014) Jonathan J. Beitler et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The Tumor Radiobiology of SRS and SBRT: Are More Than the 5 Rs Involved?

(2014) J. Martin Brown et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Irradiation and anti–PD-L1 treatment synergistically promote antitumor immunity in mice

(2014) Liufu Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Emergence of Stereotactic Body Radiation Therapy and Its Impact on Current and Future Clinical Practice

(2014) Robert D. Timmerman et al.   JOURNAL OF CLINICAL ONCOLOGY

Norm- and hypo-fractionated radiotherapy is capable of activating human dendritic cells

(2014) Lorenz Kulzer et al.   Journal of Immunotoxicology

Fractionated radiotherapy is the main stimulus for the induction of cell death and of Hsp70 release of p53 mutated glioblastoma cell lines

(2014) Yvonne Rubner et al.   Radiation Oncology

Defining Molecular Signature of Pro-Immunogenic Radiotherapy Targets in Human Prostate Cancer Cells

(2014) Molykutty J. Aryankalayil et al.   RADIATION RESEARCH

The Autophagic Response to Radiation: Relevance for Radiation Sensitization in Cancer Therapy

(2014) David A. Gewirtz   RADIATION RESEARCH

Stereotactic body radiotherapy for liver tumors

(2014) Florian Sterzing et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Stereotactic Radiation Therapy Augments Antigen-Specific PD-1-Mediated Antitumor Immune Responses via Cross-Presentation of Tumor Antigen

(2014) A. B. Sharabi et al.   Cancer Immunology Research

Trial Watch: Radioimmunotherapy for oncological indications

(2014) Norma Bloy et al.   OncoImmunology

Abscopal effects of radiotherapy on advanced melanoma patients who progressed after ipilimumab immunotherapy

(2014) Antonio M Grimaldi et al.   OncoImmunology

Radiation-induced survival responses promote immunogenic modulation to enhance immunotherapy in combinatorial regimens

(2014) Sofia R Gameiro et al.   OncoImmunology

Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death

(2014) Encouse B Golden et al.   OncoImmunology

Radiotherapy and the Tumor Stroma: The Importance of Dose and Fractionation

(2014) Turid Hellevik et al.   Frontiers in Oncology

Combinations of Immunotherapy and Radiation in Cancer Therapy

(2014) Ralph E. Vatner et al.   Frontiers in Oncology

Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy

(2013) Matthew D. Vesely et al.   Annals of the New York Academy of Sciences

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

(2013) Nuno Figueiredo et al.   IMMUNITY

Chemotherapy-induced immunogenic modulation of tumor cells enhances killing by cytotoxic T lymphocytes and is distinct from immunogenic cell death

(2013) James W. Hodge et al.   INTERNATIONAL JOURNAL OF CANCER

Treatment of Triple-Negative Breast Cancer Using Anti-EGFR-Directed Radioimmunotherapy Combined with Radiosensitizing Chemotherapy and PARP Inhibitor

(2013) F. Al-Ejeh et al.   JOURNAL OF NUCLEAR MEDICINE

Safety and Efficacy of Stereotactic Body Radiotherapy for Stage I Non–Small-Cell Lung Cancer in Routine Clinical Practice: A Patterns-of-Care and Outcome Analysis

(2013) Matthias Guckenberger et al.   Journal of Thoracic Oncology

The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials

(2013) Joanne S Haviland et al.   LANCET ONCOLOGY

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Current concepts in clinical radiation oncology

(2013) Michael Orth et al.   RADIATION AND ENVIRONMENTAL BIOPHYSICS

Definition of stereotactic body radiotherapy

(2013) M. Guckenberger et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Many faces of DAMPs in cancer therapy

(2013) O Krysko et al.   Cell Death & Disease

Turning T cells on: epigenetically enhanced expression of effector T-cell costimulatory molecules on irradiated human tumor cells

(2013) Anita Kumari et al.   Journal for ImmunoTherapy of Cancer

Synergy of Topical Toll-like Receptor 7 Agonist with Radiation and Low-Dose Cyclophosphamide in a Mouse Model of Cutaneous Breast Cancer

(2012) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

Induction of Abscopal Anti-Tumor Immunity and Immunogenic Tumor Cell Death by Ionizing Irradiation - Implications for Cancer Therapies

(2012) B. Frey et al.   CURRENT MEDICINAL CHEMISTRY

Past, present and future of radiotherapy for the benefit of patients

(2012) Juliette Thariat et al.   Nature Reviews Clinical Oncology

Radiation-Induced Vascular Damage in Tumors: Implications of Vascular Damage in Ablative Hypofractionated Radiotherapy (SBRT and SRS)

(2012) Heon Joo Park et al.   RADIATION RESEARCH

Bioeffect modeling and equieffective dose concepts in radiation oncology – Terminology, quantities and units

(2012) Søren M. Bentzen et al.   RADIOTHERAPY AND ONCOLOGY

Die Rolle der Strahlentherapie bei der Induktion von Antitumor-Immunantworten

(2012) G. Multhoff et al.   STRAHLENTHERAPIE UND ONKOLOGIE

Effects of ionizing radiation on the immune system with special emphasis on the interaction of dendritic and T cells

(2012) Katrin Manda et al.   Frontiers in Oncology

How Does Ionizing Irradiation Contribute to the Induction of Anti-Tumor Immunity?

(2012) Yvonne Rubner et al.   Frontiers in Oncology

Dying cell clearance and its impact on the outcome of tumor radiotherapy

(2012) Kirsten Lauber et al.   Frontiers in Oncology

Stereotactic body radiotherapy for colorectal liver metastases

(2011) Daniel T. Chang et al.   CANCER

Maximizing Tumor Immunity With Fractionated Radiation

(2011) Dörthe Schaue et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress

(2011) M. Bauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase I Dose-Escalation Study of Stereotactic Body Radiotherapy in Patients With Hepatic Metastases

(2010) William Rule et al.   ANNALS OF SURGICAL ONCOLOGY

Radiation-induced cell death mechanisms

(2010) David Eriksson et al.   TUMOR BIOLOGY

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

(2009) Y. Lee et al.   BLOOD

Fractionated but Not Single-Dose Radiotherapy Induces an Immune-Mediated Abscopal Effect when Combined with Anti-CTLA-4 Antibody

(2009) M. Z. Dewan et al.   CLINICAL CANCER RESEARCH

Local irradiation of murine melanoma affects the development of tumour-specific immunity

(2009) Yu-Pei Liao et al.   IMMUNOLOGY

Systemic effects of local radiotherapy

(2009) Silvia C Formenti et al.   LANCET ONCOLOGY

Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation

(2008) David A. Gewirtz et al.   BIOCHEMICAL PHARMACOLOGY

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Stereotactic Body Radiotherapy for Oligometastatic Lung Tumors

(2008) Yoshiki Norihisa et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Volumetric Modulated Arc Therapy for Delivery of Prostate Radiotherapy: Comparison With Intensity-Modulated Radiotherapy and Three-Dimensional Conformal Radiotherapy

(2008) David Palma et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS