Role of autophagy in regulating the radiosensitivity of tumor cells

Repression of the autophagic response sensitises lung cancer cells to radiation and chemotherapy

(2016) Ilias V Karagounis et al.   BRITISH JOURNAL OF CANCER

Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells

(2016) Moureq Alotaibi et al.   RADIATION RESEARCH

To live or let die: Unclear task of autophagy in the radiosensitization battle

(2016) Martin Ondrej et al.   RADIOTHERAPY AND ONCOLOGY

TLR9-ERK-mTOR signaling is critical for autophagic cell death induced by CpG oligodeoxynucleotide 107 combined with irradiation in glioma cells

(2016) Xiaoli Li et al.   Scientific Reports

Intensified autophagy compromises the efficacy of radiotherapy against prostate cancer

(2015) Michael I. Koukourakis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synergistic antitumor effects of radiation and proteasome inhibitor treatment in pancreatic cancer through the induction of autophagy and the downregulation of TRAF6

(2015) Hui-Wen Chiu et al.   CANCER LETTERS

Targeting pyruvate kinase M2 contributes to radiosensitivity of non-small cell lung cancer cells in vitro and in vivo

(2015) Mao-Bin Meng et al.   CANCER LETTERS

Blockage of Autophagy in C6 Glioma Cells Enhanced Radiosensitivity Possibly by Attenuating DNA-PK-Dependent DSB Due to Limited Ku Nuclear Translocation and DNA Binding

(2015) C. Liu et al.   CURRENT MOLECULAR MEDICINE

Suppression of autophagy augments the radiosensitizing effects of STAT3 inhibition on human glioma cells

(2015) Xiaopeng Yuan et al.   EXPERIMENTAL CELL RESEARCH

ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell

(2015) Ni Chen et al.   International Journal of Biological Sciences

The Role of HMGB1 in Radioresistance of Bladder Cancer

(2015) S. Shrivastava et al.   MOLECULAR CANCER THERAPEUTICS

Combining radiation with autophagy inhibition enhances suppression of tumor growth and angiogenesis in esophageal cancer

(2015) YONGSHUN CHEN et al.   Molecular Medicine Reports

miR-101 sensitizes human nasopharyngeal carcinoma cells to radiation by targeting stathmin 1

(2015) QUANQUAN SUN et al.   Molecular Medicine Reports

MicroRNA-216a enhances the radiosensitivity of pancreatic cancer cells by inhibiting beclin-1-mediated autophagy

(2015) XIANGLIANG ZHANG et al.   ONCOLOGY REPORTS

Canonical autophagy does not contribute to cellular radioresistance

(2015) Marco B.E. Schaaf et al.   RADIOTHERAPY AND ONCOLOGY

Gambogic acid enhances the radiosensitivity of human esophageal cancer cells by inducing reactive oxygen species via targeting Akt/mTOR pathway

(2015) Yan Yang et al.   TUMOR BIOLOGY

Autophagy and its function in radiosensitivity

(2015) Yan Yang et al.   TUMOR BIOLOGY

Andrographolide radiosensitizes human ovarian cancer SKOV3 xenografts due to an enhanced apoptosis and autophagy

(2015) Chao Zhang et al.   TUMOR BIOLOGY

NSCLC cells demonstrate differential mode of cell death in response to the combined treatment of radiation and a DNA-PKcs inhibitor

(2015) Lan Yu et al.   Oncotarget

Carbon ions induce autophagy effectively through stimulating the unfolded protein response and subsequent inhibiting Akt phosphorylation in tumor cells

(2015) Xiaodong Jin et al.   Scientific Reports

A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089

(2015) Khushboo Sharma et al.   Autophagy

DAB2IP Regulates Autophagy in Prostate Cancer in Response to Combined Treatment of Radiation and a DNA-PKcs Inhibitor

(2015) Lan Yu et al.   NEOPLASIA

The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells

(2014) Feng-Ze Wang et al.   APOPTOSIS

Oncogenic and tumor suppressive roles of microRNAs in apoptosis and autophagy

(2014) Y. Chen et al.   APOPTOSIS

Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer

(2014) Kwang Woon Kim et al.   Autophagy

Autophagy: An emerging target for cancer therapy

(2014) Maria Høyer-Hansen et al.   Autophagy

Featured Article: Autophagic activation with Nimotuzumab enhanced chemosensitivity and radiosensitivity of esophageal squamous cell carcinoma

(2014) Haizhu Song et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

MiR-200c inhibits autophagy and enhances radiosensitivity in breast cancer cells by targeting UBQLN1

(2014) Quanquan Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Everolimus sensitizes Ras-transformed cells to radiation in vitro through the autophagy pathway

(2014) YU-CHIEH SU et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Apogossypolone, a small-molecule inhibitor of Bcl-2, induces radiosensitization of nasopharyngeal carcinoma cells by stimulating autophagy

(2014) JIN-HUA HE et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Inhibition of autophagy enhances the radiosensitivity of nasopharyngeal carcinoma by reducing Rad51 expression

(2014) NING MO et al.   ONCOLOGY REPORTS

Torc1/Torc2 inhibitor, Palomid 529, enhances radiation response modulating CRM1-mediated survivin function and delaying DNA repair in prostate cancer models

(2014) Giovanni Luca Gravina et al.   PROSTATE

PI3K/Akt/mTOR pathway inhibitors enhance radiosensitivity in radioresistant prostate cancer cells through inducing apoptosis, reducing autophagy, suppressing NHEJ and HR repair pathways

(2014) L Chang et al.   Cell Death & Disease

The Importance of Autophagy Regulation in Breast Cancer Development and Treatment

(2014) Joanna Magdalena Zarzynska   Biomed Research International

Blocked autophagy enhances radiosensitivity of nasopharyngeal carcinoma cell line CNE-2 in vitro

(2013) Yusheng Wang et al.   ACTA OTO-LARYNGOLOGICA

NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro

(2013) Wen-juan Wang et al.   ACTA PHARMACOLOGICA SINICA

MicroRNA targets autophagy in pancreatic cancer cells during cancer therapy

(2013) Peng Wang et al.   Autophagy

Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling

(2013) A Ko et al.   CELL DEATH AND DIFFERENTIATION

Profilin1 Sensitizes Pancreatic Cancer Cells to Irradiation by Inducing Apoptosis and Reducing Autophagy

(2013) H. Cheng et al.   CURRENT MOLECULAR MEDICINE

Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Enhances Radiosensitivity and Suppresses Lung Metastasis in Breast Cancer In Vitro and In Vivo

(2013) Hui-Wen Chiu et al.   PLoS One

Inhibition of autophagy induced by TSA sensitizes colon cancer cell to radiation

(2013) Gang He et al.   TUMOR BIOLOGY

MicroRNA regulation of autophagy

(2012) L. B. Frankel et al.   CARCINOGENESIS

Disrupting the mTOR Signaling Network as a Potential Strategy for the Enhancement of Cancer Radiotherapy

(2012) Francis J. Dumont et al.   CURRENT CANCER DRUG TARGETS

Cancer and Radiation Therapy: Current Advances and Future Directions

(2012) Rajamanickam Baskar et al.   International Journal of Medical Sciences

The mTOR inhibitor RAD001 augments radiation-induced growth inhibition in a hepatocellular carcinoma cell line by increasing autophagy

(2012) ANAÏS ALTMEYER et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Different involvement of autophagy in human malignant glioma cell lines undergoing irradiation and temozolomide combined treatments

(2012) Silvia Palumbo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

mTOR inhibitors radiosensitize PTEN-deficient non-small-cell lung cancer cells harboring anEGFRactivating mutation by inducing autophagy

(2012) Eun Ju Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Autophagy and ionizing radiation in tumors: The “survive or not survive” dilemma

(2012) Silvia Palumbo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Arsenic Trioxide Enhances the Radiation Sensitivity of Androgen-Dependent and -Independent Human Prostate Cancer Cells

(2012) Hui-Wen Chiu et al.   PLoS One

Monascuspiloin Enhances the Radiation Sensitivity of Human Prostate Cancer Cells by Stimulating Endoplasmic Reticulum Stress and Inducing Autophagy

(2012) Hui-Wen Chiu et al.   PLoS One

Autophagy inhibition plays the synergetic killing roles with radiation in the multi-drug resistant SKVCR ovarian cancer cells

(2012) Bing Liang et al.   Radiation Oncology

Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy

(2012) Selvakumar Anbalagan et al.   RADIOTHERAPY AND ONCOLOGY

Autophagy contributes to resistance of tumor cells to ionizing radiation

(2011) Hassan Chaachouay et al.   RADIOTHERAPY AND ONCOLOGY

A Switch Between Cytoprotective and Cytotoxic Autophagy in the Radiosensitization of Breast Tumor Cells by Chloroquine and Vitamin D

(2011) Eden N. Wilson et al.   Hormones & Cancer

Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis

(2010) Hui-Wen Chiu et al.   Autophagy

Autophagy is a therapeutic target in anticancer drug resistance

(2010) Suning Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Knockdown of the DNA-dependent protein kinase catalytic subunit radiosensitizes glioma-initiating cells by inducing autophagy

(2010) Wenzhuo Zhuang et al.   BRAIN RESEARCH

Targeting HER2 signaling pathway for radiosensitization: Alternative strategy for therapeutic resistance

(2010) Mina No et al.   CANCER BIOLOGY & THERAPY

Autophagy inhibition contributes to radiation sensitization of esophageal squamous carcinoma cells

(2010) Y. S. Chen et al.   DISEASES OF THE ESOPHAGUS

Targeting Epidermal Growth Factor Receptor-Associated Signaling Pathways in Non-Small Cell Lung Cancer Cells: Implication in Radiation Response

(2010) E. J. Choi et al.   MOLECULAR CANCER RESEARCH

Alisol B, a Novel Inhibitor of the Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase Pump, Induces Autophagy, Endoplasmic Reticulum Stress, and Apoptosis

(2010) B. Y. K. Law et al.   MOLECULAR CANCER THERAPEUTICS

The role of autophagy in sensitizing malignant glioma cells to radiation therapy

(2009) W. Zhuang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways

(2009) Hui-Wen Chiu et al.   Autophagy

Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: A crucial role of AMPK and mTOR pathways

(2009) Po-Cheng Chiang et al.   BIOCHEMICAL PHARMACOLOGY

Role and regulation of autophagy in cancer

(2009) Ning Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Promotion of autophagy as a mechanism for radiation sensitization of breast tumor cells

(2009) David A. Gewirtz et al.   RADIOTHERAPY AND ONCOLOGY

Blocked Autophagy Sensitizes Resistant Carcinoma Cells to Radiation Therapy

(2008) A. Apel et al.   CANCER RESEARCH

M867, a Novel Selective Inhibitor of Caspase-3 Enhances Cell Death and Extends Tumor Growth Delay in Irradiated Lung Cancer Models

(2008) Kwang Woon Kim et al.   PLoS One