Article
Medicine, Research & Experimental
Xingyu Du, Xueyuan Zhang, Jing Dong, Naiyi Zou, Dong Guo, Weinan Yao, Xiaobin Wang, Shuguang Li, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: High expression of plasma exosomal HMGB1 is associated with an adverse radiotherapy response in ESCC patients. IR-induced exosomal HMGB1 enhances the radioresistance of ESCC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Surashri Shinde-Jadhav, Jose Joao Mansure, Roni F. Rayes, Gautier Marcq, Mina Ayoub, Rodrigo Skowronski, Ronald Kool, France Bourdeau, Fadi Brimo, Jonathan Spicer, Wassim Kassouf
Summary: Radioresistance in bladder cancer treatment is linked to the recruitment of neutrophil extracellular traps (NETs) to the tumor immune microenvironment post-radiation therapy, as demonstrated in a mouse model. Inhibition of NETs can improve radiation response, suggesting NETs as a potential therapeutic target to enhance radiation efficacy.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Lixia Wang, Chuanlai Yang, Man Chu, Zhi-wei Wang, Boxin Xue
Summary: The study investigated the molecular mechanisms underlying radioresistance in bladder cancer, revealing elevated Cdc20 expression in IR cells and its role in governing IR-mediated EMT by regulating FoxO1 degradation. Therefore, inhibiting Cdc20 or activating FoxO1 may be potential strategies to overcome radioresistance in bladder cancer.
Review
Medicine, Research & Experimental
Xiangqi Chen, Qian Liu, Enqing Wu, Zhiyuan Ma, Biguang Tuo, Shuji Terai, Taolang Li, Xuemei Liu
Summary: HMGB1 plays an important role in digestive cancer by participating in pathways of digestive tissue injury and tumor development, and by promoting antitumor immune response. Therefore, targeted therapies against HMGB1 are of great significance in the treatment of digestive cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biology
Pratik Thapa, Hong Jiang, Na Ding, Yanning Hao, Aziza Alshahrani, Qiou Wei
Summary: Peroxiredoxins (Prxs) are widely expressed antioxidant enzymes in human tissues, and they are also present in archaea, bacteria, and eukaryota. Prxs play a crucial role in defending against oxidative stress due to their abundant expression in different cellular organelles and high sensitivity to H2O2. They are upregulated in cancer cells and can function as tumor promoters in various cancers. This review aims to summarize recent discoveries regarding the roles of Prxs in common cancer types and highlight their potential significance in improving cancer therapeutics and patient survival.
Article
Oncology
Jing Dong, Xueyuan Zhang, Xingyu Du, Naiyi Zou, Wenbin Shen, Ming Ma, Yaojie Wang, Shuchai Zhu
Summary: The study found that overexpression of HMGB1 promotes migration, proliferation, and radioresistance of esophageal squamous cell carcinoma cells, and mitigates cell cycle arrest induced by irradiation at the G0/G1 phase. Negative expression of HMGB1 is associated with 10-year survival in ESCC patients.
Review
Cell Biology
Zhenyi Yang, Wen Zhong, Liang Yang, Ping Wen, Yixuan Luo, Chunli Wu
Summary: Radiotherapy is commonly used in cancer treatment, but radioresistance and radiation-induced bystander effects remain challenging. Exosomes play a significant role in radiotherapy by mediating intercellular signaling pathways and participating in the mechanisms of radioresistance and radiation-induced bystander effects.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Xueyuan Zhang, Naiyi Zou, Wenzhao Deng, Chunyang Song, Ke Yan, Wenbin Shen, Shuchai Zhu
Summary: This study found that down-regulation of HMGB1 can promote the radiosensitivity of esophageal cancer cells through regulating the PI3K/Akt/ATM pathway, leading to improved prognosis for patients.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Oncology
Chun-Ming Huang, Hsiang-Lin Tsai, Yen-Cheng Chen, Ching-Wen Huang, Ching-Chun Li, Wei-Chih Su, Tsung-Kun Chang, Yung-Sung Yeh, Po-Jung Chen, Ming-Yii Huang, Jaw-Yuan Wang
Summary: This review discusses the roles and mechanisms of non-coding RNAs (including lncRNA, miRNA, and circRNA) in regulating the radiosensitivity of colorectal cancer (CRC), as well as evaluates their potential as therapeutic targets and predictive biomarkers for CRC treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shingo Kishi, Yukiko Nishiguchi, Kanya Honoki, Shiori Mori, Rina Fujiwara-Tani, Takamitsu Sasaki, Kiyomu Fujii, Isao Kawahara, Kei Goto, Chie Nakashima, Akira Kido, Yasuhito Tanaka, Yi Luo, Hiroki Kuniyasu
Summary: CML modification of HMGB1 enhances cancer-promoting effects by promoting cell proliferation, invasion, resistance to therapy, and is associated with oxidative stress and resistance in cancer tissues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Jedrzej Borowczak, Krzysztof Szczerbowski, Mateusz Maniewski, Marek Zdrenka, Piotr Slupski, Paulina Antosik, Sylwia Kolodziejska, Marta Sekielska-Domanowska, Mariusz Dubiel, Magdalena Bodnar, Lukasz Szylberg
Summary: This article investigates the prognostic role of cyclin-dependent kinase 9 expression in urothelial carcinoma. The results show that high CDK9 expression is associated with a better prognosis, tumor grade, stage, and invasiveness, contradicting previous findings. CDK9 may play a crucial role in the early stages of urothelial carcinoma.
Article
Multidisciplinary Sciences
Dominic Leiser, Santanu Samanta, John Eley, Josh Strauss, Michael Creed, Tami Kingsbury, Paul N. Staats, Binny Bhandary, Minjie Chen, Tijana Dukic, Sanjit Roy, Javed Mahmood, Zeljko Vujaskovic, Hem D. Shukla
Summary: The study highlights the role of Caveolin-1 in radioresistance of lung cancer cells, as well as its contribution to tumor aggression. The heterogeneous expression of the CAV-1 gene in human lung cancer tissues is similar to its enhanced expression in human lung cancer cell line and mouse orthotopic xenograft models. Alterations in the CAV-1 gene have been linked to poor prognosis and survival in lung cancer patients.
Article
Biology
Zhi Xiong Chong, Swee Keong Yeap, Wan Yong Ho
Summary: miRNAs play important roles in regulating the response of breast cancer cells to radiotherapy, with some miRNAs playing key roles in mediating radio-responses.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Review
Oncology
Rhianna Mae Hill, Matthew Fok, Gabrielle Grundy, Jason Luke Parsons, Sonia Rocha
Summary: This literature review explores the complex relationship between radiotherapy, hypoxia, and autophagy in cancer treatment, providing valuable insights into the potential of targeting autophagy as a therapeutic strategy to improve the response of hypoxic tumors to radiotherapy.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qianqian Xu, Peiyu Zhang, Xiaoyan Han, Huwei Ren, Weiyue Yu, Wei Hao, Bowen Luo, Muhammad Imran Khan, Ni Chen
Summary: This study investigates the pivotal role of Nuclear factor-erythroid 2-related factor 2 (NRF2) in the activation of DNA damage repair in lung cancer cells after x-rays exposure. The study shows that NRF2 knockdown disrupts damaged DNA repair and homologous recombination, and NRF2 activation mediates DNA damage response via the MAPK pathway. These findings suggest that NRF2 plays a critical role in the development of radioresistance, which is of great significance for the development of radiotherapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Talia Malagon, Jean H. E. Yong, Parker Tope, Wilson H. Miller, Eduardo L. Franco
Summary: This study used a microsimulation model to estimate the long-term impacts of cancer care disruptions during the COVID-19 pandemic in Canada. It predicted over 21,000 additional cancer deaths between 2020 and 2030, with the potential to mitigate these losses by increasing diagnostic and treatment capacity in the short term.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Oncology
Ahmad Almarzouq, Ronald Kool, Yarab Al Bulushi, Gautier Marcq, Luis Souhami, Fabio L. Cury, Fadi Brimo, Jaron Chong, Wassim Kassouf
Summary: This study investigated the incidence of sarcopenia and its impact on oncological outcomes in MIBC patients treated with trimodal therapy. The results showed that sarcopenia status was not independently associated with either complete response to TMT or overall survival.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Oncology
Gustavo A. Viani, Andre G. Gouveia, Fabio Y. Moraes, Fabio L. Cury
Summary: This meta-analysis evaluates the outcomes of patients treated with moderate hypofractionated radiation therapy (MHF-RT) with elective pelvic nodal irradiation (EPNI) using modern techniques. The results show that EPNI with concomitant MHF-RT provides satisfactory biochemical relapse-free survival in long-term follow-up, with low rates of toxic effects.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Shankar Siva, Muhammad Ali, Rohann J. M. Correa, Alexander Muacevic, Lee Ponsky, Rodney J. Ellis, Simon S. Lo, Hiroshi Onishi, Anand Swaminath, Mark McLaughlin, Scott C. Morgan, Fabio L. Cury, Bin S. Teh, Anand Mahadevan, Irving D. Kaplan, William Chu, William Grubb, Raquibul Hannan, Michael Staehler, Andrew Warner, Alexander V. Louie
Summary: This study reports the long-term efficacy and safety of stereotactic ablative body radiotherapy (SABR) for localized renal cell carcinoma. The cumulative incidence of local failure at 5 years was 5.5%, with single-fraction SABR resulting in fewer local failures than multifraction SABR. There were no grade 3 toxic effects or treatment-related deaths. The results demonstrate the effectiveness and safety of SABR as a treatment option for patients with primary renal cell carcinoma.
Article
Oncology
David Santiago Ayala Alvarez, Peter G. F. Watson, Marija Popovic, Veng Jean Heng, Michael D. C. Evans, Valerie Panet-Raymond, Jan Seuntjens
Summary: The study evaluates the effect of dosimetry formalism on organs at risk (OAR) doses in patients with glioblastoma treated with intraoperative radiation therapy (IORT). The more accurate Monte Carlo (MC) calculation of dose-to-tissue led to the highest dosimetric differences, which may have important implications for clinical practice.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Clinical Neurology
Melissa Henry, Raphaele Harvey, Lawrence M. Chen, Michael Meaney, Thi Thu Thao Nguyen, Han-Tin Kao, Zeev Rosberger, Saul Frenkiel, Michael Hier, Anthony Zeitouni, Karen Kost, Alex Mlynarek, Keith Richardson, Celia M. T. Greenwood, David Melnychuk, Phil Gold, Gabrielle Chartier, Martin Black, Marco Mascarella, Christina MacDonald, Nader Sadeghi, Khalil Sultanem, Georges Shenouda, Fabio Cury, Kieran John O'Donnell
Summary: The study investigates the impact of genetic predispositions to depression and inflammation on symptom burden in head and neck cancer patients. It suggests that genetic predisposition, anxiety disorders, and radiotherapy dosage contribute to symptom burden. Early interventions targeting genetic predisposition and psychological factors may help alleviate symptom burden in cancer patients.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Oncology
Daniel J. Krauss, Theodore Karrison, Alvaro A. Martinez, Gerard Morton, Di Yan, Deborah Watkins Bruner, Benjamin Movsas, Mohamed Elshaikh, Deborah Citrin, Bruce Hershatter, Jeff M. Michalski, Jason Alexander Efstathiou, Adam Currey, Vivek S. Kavadi, Fabio L. Cury, Michael Lock, Adam Raben, Samantha Andrews Seaward, Ali El-Gayed, Joseph P. Rodgers, Howard M. Sandler
Summary: This study found that short-term androgen deprivation therapy did not improve the overall survival rates in men with intermediate-risk prostate cancer treated with dose-escalated radiotherapy. However, it did lower prostate cancer-specific mortality, distant metastases, and PSA failure rates.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Benjamin Movsas, Joseph P. P. Rodgers, Mohamed A. A. Elshaikh, Alvaro A. A. Martinez, Gerard C. C. Morton, Daniel J. J. Krauss, Di Yan, Deborah E. E. Citrin, Bruce W. W. Hershatter, Jeff M. M. Michalski, Rodney J. J. Ellis, Vivek S. S. Kavadi, Elizabeth M. M. Gore, Gary S. S. Gustafson, Craig A. A. Schulz, Vikram M. M. Velker, Adam C. C. Olson, Fabio L. L. Cury, Michael A. A. Papagikos, Theodore G. G. Karrison, Howard M. M. Sandler, Deborah W. W. Bruner
Summary: This study reports the patient-reported outcomes of a phase III trial evaluating total androgen suppression combined with dose-escalated radiation therapy for intermediate-risk prostate cancer. The results showed clinically meaningful declines in the hormonal and sexual domains in the RT + TAS group, but these differences disappeared by 1 year.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Verity Ahern, Sebastian Adeberg, Piero Fossati, Richard Garrett, Bradford Hoppe, Anita Mahajan, Ester Orlandi, Roberto Orecchia, Dale Prokopovich, Jan Seuntjens, David Thwaites, Daniel Trifiletti, Richard Tsang, Hiroshi Tsuji
Summary: This study aims to establish the treatment indications and potential patient numbers for carbon ion radiation therapy (CIRT) at a proposed national carbon ion (and proton) therapy facility in New South Wales, Australia. An expert panel, including representatives from operational and proposed international carbon ion facilities, as well as local stakeholders, met virtually to discuss the available evidence and experience. The study concluded that CIRT can be justified in Australia for certain tumor types, including adenoid cystic carcinomas, mucosal melanomas, hepatocellular cancer, liver metastases, base of skull meningiomas, chordomas, and chondrosarcomas. Approximately 1400 Australian patients annually meet the consensus-derived indications.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Stuart J. Wong, Pedro A. Torres-Saavedra, Nabil F. Saba, George Shenouda, Jeffrey M. Bumpous, Robert E. Wallace, Christine H. Chung, Adel K. El-Naggar, Clement K. Gwede, Barbara Burtness, Paul A. Tennant, Neal E. Dunlap, Rebecca Redman, William A. Stokes, Soumon Rudra, Loren K. Mell, Assuntina G. Sacco, Sharon A. Spencer, Lisle Nabell, Min Yao, Fabio L. Cury, Darrion L. Mitchell, Christopher U. Jones, Selim Firat, Joseph N. Contessa, Thomas Galloway, Adam Currey, Jonathan Harris, Walter J. Curran Jr, Quynh-Thu Le
Summary: This study investigated whether adding lapatinib to radiation plus cisplatin for frontline therapy of stage III to IV non-HPV head and neck cancer patients improves progression-free survival.
Meeting Abstract
Urology & Nephrology
Daniel Halstuch, Ronald Kool, Gautier Marcq, Rodney H. Breau, Peter C. Black, Bobby Shayegan, Michael Kim, Ionut Busca, Hamidreza Abdi, Mark T. Dawidek, Michael Uy, Gagan Fervaha, Fabio L. Cury, Nimira S. Alimohamed, Claudio Jeldres, Ricardo Rendon, D. Robert Siemens, Girish S. Kulkarni, Wassim Kassouf, Jonathan I. Izawa
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Ronald Kool, Gautier Marcq, Alice Dragomir, Girish Kulkarni, Rodney H. Breau, Michael Kim, Ionut Busca, Hamidreza Abdi, Mark Dawidek, Michael Uy, Gagan Fervaha, Nimira Alimohamed, Jonathan Izawa, Claudio Jeldres, Ricardo Rendon, Bobby Shayegan, Robert Siemens, Peter C. Black, Fabio L. Cury, Wassim Kassouf
JOURNAL OF UROLOGY
(2023)
Article
Oncology
Fabio L. Cury, Gustavo A. Viani, Andre G. Gouveia, Camila V. S. Freire, Gabriel de A. Grisi, Fabio Y. Moraes
Summary: In limb-sparing treatment of soft tissue sarcoma patients, a 5-day course of preoperative radiotherapy results in high local control and favorable R0 margins, with acceptable complication rates, particularly for patients receiving higher biological equivalent doses.
RADIOTHERAPY AND ONCOLOGY
(2024)
Meeting Abstract
Oncology
S. Siva, R. J. M. Correa, M. Ali, A. Muacevic, L. Ponsky, R. J. Ellis, S. S. Lo, H. Onishi, A. Swaminath, M. McLaughlin, S. C. Morgan, F. Cury, B. S. Teh, A. Mahadevan, I. D. Kaplan, W. Chu, R. Hannan, M. Staehler, A. Warner, A. V. Louie
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Meeting Abstract
Oncology
Rie Asso, Horacio Patrocinio, Paul Ramia, Marcos Castilho, Arthur Rosa, Joao Luis Silva, Fabio Cury
RADIOTHERAPY AND ONCOLOGY
(2022)