Macrophage polarization in innate immune responses contributing to pathogenesis of chronic kidney disease

Zoledronic acid promotes TLR-4–mediated M1 macrophage polarization in bisphosphonate-related osteonecrosis of the jaw

(2019) Weiwen Zhu et al.   FASEB JOURNAL

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

(2019) Yang Yang et al.   Cell Death & Disease

Macrophages: versatile players in renal inflammation and fibrosis

(2019) Patrick Ming-Kuen Tang et al.   Nature Reviews Nephrology

M2 macrophages in kidney disease: biology, therapies, and perspectives

(2019) Titi Chen et al.   KIDNEY INTERNATIONAL

The role of inflammasomes in kidney disease

(2019) Takanori Komada et al.   Nature Reviews Nephrology

APOL1 renal risk variants promote cholesterol accumulation in tissues and cultured macrophages from APOL1 transgenic mice

(2019) Jung-Hwa Ryu et al.   PLoS One

Human Monocyte Subsets and Phenotypes in Major Chronic Inflammatory Diseases

(2019) Theodore S. Kapellos et al.   Frontiers in Immunology

Inflammation in Renal Diseases: New and Old Players

(2019) Vinicius Andrade-Oliveira et al.   Frontiers in Pharmacology

High Levels of IL-18 and IFN-γ in Chronically Inflamed Tissue in Chronic Granulomatous Disease

(2019) Virginia Meda Spaccamela et al.   Frontiers in Immunology

Alterations in plasma membrane ion channel structures stimulate NLRP3 inflammasome activation in APOL1 risk milieu

(2019) Alok Jha et al.   FEBS Journal

Inhibition of the NLRP3 inflammasome attenuates foam cell formation of THP-1 macrophages by suppressing ox-LDL uptake and promoting cholesterol efflux

(2018) Liang Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Simultaneous activation of innate and adaptive immunity participates in the development of renal injury in a model of heavy proteinuria

(2018) Viviane Dias Faustino et al.   BIOSCIENCE REPORTS

Metabolic regulation of macrophages in tissues

(2018) Jan Van den Bossche et al.   CELLULAR IMMUNOLOGY

Apolipoprotein L1 nephropathies

(2018) Jeffrey B. Kopp et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

M1/M2 macrophages in diabetic nephropathy: Nrf2/HO-1 as therapeutic targets

(2018) R. Clive Landis et al.   CURRENT PHARMACEUTICAL DESIGN

The metabolic axis of macrophage and immune cell polarization

(2018) Spencer A. Hobson-Gutierrez et al.   Disease Models & Mechanisms

Chronic kidney disease induces inflammation by increasing Toll-like receptor-4, cytokine and cathelicidin expression in neutrophils and monocytes

(2018) Caren C. Grabulosa et al.   EXPERIMENTAL CELL RESEARCH

The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1–mediated tissue injury

(2018) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

A positive feedback loop between IL-1β, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages

(2018) Irina Sieve et al.   VASCULAR PHARMACOLOGY

Chronic kidney disease alters lipid trafficking and inflammatory responses in macrophages: effects of liver X receptor agonism

(2018) Ryohei Kaseda et al.   BMC Nephrology

Innate immunity and Toll-like receptor signaling in the pathogenesis of scleroderma

(2018) Max Brown et al.   CURRENT OPINION IN RHEUMATOLOGY

Pharmacological Inhibition of Toll-Like Receptor-4 Signaling by TAK242 Prevents and Induces Regression of Experimental Organ Fibrosis

(2018) Swati Bhattacharyya et al.   Frontiers in Immunology

NLRP3 Inflammasome: A Possible Link Between Obesity-Associated Low-Grade Chronic Inflammation and Colorectal Cancer Development

(2018) Patricia Ahechu et al.   Frontiers in Immunology

Macrophage plasticity, polarization and function in response to curcumin, a diet-derived polyphenol, as an immunomodulatory agent

(2018) Asadollah Mohammadi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Metabolic regulation of NLRP3

(2017) Mark M. Hughes et al.   IMMUNOLOGICAL REVIEWS

Wnt/ β -Catenin–Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis

(2017) Ye Feng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Relaxin abrogates renal interstitial fibrosis by regulating macrophage polarization via inhibition of Toll-like receptor 4 signaling

(2017) Lei Chen et al.   Oncotarget

Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice

(2017) Yuji Sogawa et al.   Scientific Reports

NLRP3 inflammasome: Pathogenic role and potential therapeutic target for IgA nephropathy

(2017) Yu-Ling Tsai et al.   Scientific Reports

Innate And Adaptive Immunity are Progressively Activated in Parallel with Renal Injury in the 5/6 Renal Ablation Model

(2017) Camilla Fanelli et al.   Scientific Reports

The Origins and Functions of Tissue-Resident Macrophages in Kidney Development

(2017) David A. D. Munro et al.   Frontiers in Physiology

Toll-like Receptor 4 Deficiency Reduces Oxidative Stress and Macrophage Mediated Inflammation in Hypertensive Kidney

(2017) Sathnur Pushpakumar et al.   Scientific Reports

Transfusion of CD206+ M2 Macrophages Ameliorates Antibody-Mediated Glomerulonephritis in Mice

(2016) Qiuna Du et al.   AMERICAN JOURNAL OF PATHOLOGY

The critical role of toll-like receptors — From microbial recognition to autoimmunity: A comprehensive review

(2016) Maximiliano Javier Jiménez-Dalmaroni et al.   AUTOIMMUNITY REVIEWS

Inflammation and Progression of CKD: The CRIC Study

(2016) R. L. Amdur et al.   Clinical Journal of the American Society of Nephrology

IL-1β promotes tubulointerstitial injury in 
MPO-ANCA-associated glomerulonephritis


(2016) Manabu Tashiro et al.   CLINICAL NEPHROLOGY

Prostaglandin E2 promotes M2 polarization of macrophages via a cAMP/CREB signaling pathway and deactivates granulocytes in teleost fish

(2016) Jana Montero et al.   FISH & SHELLFISH IMMUNOLOGY

Molecular mechanisms of regulation of Toll-like receptor signaling

(2016) Cynthia A. Leifer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The global burden of chronic kidney disease: estimates, variability and pitfalls

(2016) Richard J. Glassock et al.   Nature Reviews Nephrology

Regulatory T cells in immune-mediated renal disease

(2016) Joanna R Ghali et al.   NEPHROLOGY

The NLRP3 inflammasome in kidney disease and autoimmunity

(2016) Holly L Hutton et al.   NEPHROLOGY

Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes

(2016) Ekta Lachmandas et al.   Nature Microbiology

Integrative Genomics Identifies Novel Associations with APOL1 Risk Genotypes in Black NEPTUNE Subjects

(2015) M. G. Sampson et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Innate immunity pathways regulate the nephropathy gene Apolipoprotein L1

(2015) Brendan Nichols et al.   KIDNEY INTERNATIONAL

Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: Relevance to trypanosome lysis

(2015) Russell Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOL1 Kidney Disease Risk Variants: An Evolving Landscape

(2015) Patrick D. Dummer et al.   SEMINARS IN NEPHROLOGY

The emerging role of the inflammasome in kidney diseases

(2014) Anthony Chang et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Pattern recognition receptors and the inflammasome in kidney disease

(2014) Jaklien C. Leemans et al.   Nature Reviews Nephrology

Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody

(2013) M Reilly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Renal Protective Effects of Toll-like Receptor 4 Signaling Blockade in Type 2 Diabetic Mice

(2013) J. J. Cha et al.   ENDOCRINOLOGY

Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-like Receptor-2

(2013) Thimoteus Speer et al.   IMMUNITY

Human Lipopolysaccharide-binding Protein (LBP) and CD14 Independently Deliver Triacylated Lipoproteins to Toll-like Receptor 1 (TLR1) and TLR2 and Enhance Formation of the Ternary Signaling Complex

(2013) Diana Rose E. Ranoa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage Phenotype Controls Long-Term AKI Outcomes--Kidney Regeneration versus Atrophy

(2013) M. Lech et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Innate Immune Factor Apolipoprotein L1 Restricts HIV-1 Infection

(2013) H. E. Taylor et al.   JOURNAL OF VIROLOGY

Increased mitochondrial activity in renal proximal tubule cells from young spontaneously hypertensive rats

(2013) Hewang Lee et al.   KIDNEY INTERNATIONAL

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(2013) Tarcio Braga et al.   MOLECULAR MEDICINE

Role of the Toll Like Receptor (TLR) Radical Cycle in Chronic Inflammation: Possible Treatments Targeting the TLR4 Pathway

(2013) Kurt Lucas et al.   MOLECULAR NEUROBIOLOGY

Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis

(2013) Georg Lorenz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Uric acid and chronic kidney disease: which is chasing which?

(2013) R. J. Johnson et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9

(2013) Ekambar R. Kandimalla et al.   NUCLEIC ACIDS RESEARCH

Interleukin-18, more than a Th1 cytokine

(2013) Daniela Novick et al.   SEMINARS IN IMMUNOLOGY

Genetic Risk Prediction for CKD: A Journey of a Thousand Miles

(2011) Jeffrey B. Kopp et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Knockout of Toll-Like Receptor-2 Attenuates Both the Proinflammatory State of Diabetes and Incipient Diabetic Nephropathy

(2011) Sridevi Devaraj et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification of alternatively activated macrophages in new-onset paediatric and adult immunoglobulin A nephropathy: potential role in mesangial matrix expansion

(2011) Yohei Ikezumi et al.   HISTOPATHOLOGY

APOL1 Genetic Variants in Focal Segmental Glomerulosclerosis and HIV-Associated Nephropathy

(2011) J. B. Kopp et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis

(2011) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The trypanolytic factor of human serum: many ways to enter the parasite, a single way to kill

(2010) Benoit Vanhollebeke et al.   MOLECULAR MICROBIOLOGY

Toll-like receptor expression in monocytes in patients with chronic kidney disease and haemodialysis: relation with inflammation

(2010) M. Koc et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans

(2010) G. Genovese et al.   SCIENCE

Novel targets and new potential: developments in the treatment of inflammation in chronic kidney disease

(2008) Csaba P Kovesdy et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

IL-18 is involved in vascular injury in end-stage renal disease patients

(2008) T. Porazko et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION