Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis

Self Double-Stranded (ds)DNA Induces IL-1  Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti-dsDNA Antibodies

(2013) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Signaling by Myeloid C-Type Lectin Receptors in Immunity and Homeostasis

(2012) David Sancho et al.   Annual Review of Immunology

Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats

(2012) Qing-Hua Hu et al.   BIOCHEMICAL PHARMACOLOGY

Activation of Nod-Like Receptor Protein 3 Inflammasomes Turns on Podocyte Injury and Glomerular Sclerosis in Hyperhomocysteinemia

(2012) Chun Zhang et al.   HYPERTENSION

Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion

(2012) Shrikant R. Mulay et al.   JOURNAL OF CLINICAL INVESTIGATION

U1-Small Nuclear Ribonucleoprotein Activates the NLRP3 Inflammasome in Human Monocytes

(2012) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

Downregulation of the Na/K-ATPase Pump by Leptospiral Glycolipoprotein Activates the NLRP3 Inflammasome

(2012) S. Lacroix-Lamande et al.   JOURNAL OF IMMUNOLOGY

Inflammasome-Independent NLRP3 Augments TGF-  Signaling in Kidney Epithelium

(2012) W. Wang et al.   JOURNAL OF IMMUNOLOGY

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Uromodulin Triggers IL-1 -Dependent Innate Immunity via the NLRP3 Inflammasome

(2012) M. N. Darisipudi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of inflammasome signaling

(2012) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Quercetin and Allopurinol Ameliorate Kidney Injury in STZ-Treated Rats with Regulation of Renal NLRP3 Inflammasome Activation and Lipid Accumulation

(2012) Chuang Wang et al.   PLoS One

Renal IL-18 Production Is Macrophage Independent During Obstructive Injury

(2012) Ethan I. Franke et al.   PLoS One

ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation

(2012) N Riteau et al.   Cell Death & Disease

The inflammasome drives protective Th1 and Th17 cellular responses in disseminated candidiasis

(2011) Frank L. van de Veerdonk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epithelial-mesenchymal transition (EMT) in kidney fibrosis: fact or fantasy?

(2011) Wilhelm Kriz et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular pathophysiology of ischemic acute kidney injury

(2011) Joseph V. Bonventre et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Cyclic Polypeptide and Aminoglycoside Antibiotics Trigger IL-1  Secretion by Activating the NLRP3 Inflammasome

(2011) R. Allam et al.   JOURNAL OF IMMUNOLOGY

The Inflammasomes in Kidney Disease

(2011) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Interleukin-18 Stimulates a Positive Feedback Loop During Renal Obstruction via Interleukin-18 Receptor

(2011) Brian A. VanderBrink et al.   JOURNAL OF UROLOGY

Activation of innate immune defense mechanisms contributes to polyomavirus BK-associated nephropathy

(2011) Andrea Ribeiro et al.   KIDNEY INTERNATIONAL

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Polyene Macrolide Antifungal Drugs Trigger Interleukin-1β Secretion by Activating the NLRP3 Inflammasome

(2011) Murthy Narayana Darisipudi et al.   PLoS One

Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1

(2011) Julia Lichtnekert et al.   PLoS One

Pivotal Role of Toll-Like Receptors 2 and 4, Its Adaptor Molecule MyD88, and Inflammasome Complex in Experimental Tubule-Interstitial Nephritis

(2011) Matheus Correa-Costa et al.   PLoS One

The Sterile Inflammatory Response

(2010) Kenneth L. Rock et al.   Annual Review of Immunology

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice

(2010) M. Lech et al.   INTERNATIONAL IMMUNOLOGY

Molecular Mechanism of NLRP3 Inflammasome Activation

(2010) Chengcheng Jin et al.   JOURNAL OF CLINICAL IMMUNOLOGY

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

(2010) A. A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Evolution and functional divergence of NLRP genes in mammalian reproductive systems

(2009) Xin Tian et al.   BMC EVOLUTIONARY BIOLOGY

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

(2009) Irving C. Allen et al.   IMMUNITY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NLRP3/Cryopyrin Is Necessary for Interleukin-1β (IL-1β) Release in Response to Hyaluronan, an Endogenous Trigger of Inflammation in Response to Injury

(2009) Kenshi Yamasaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of the Nlrp3 Inflammasome by Streptococcus pyogenes Requires Streptolysin O and NF- B Activation but Proceeds Independently of TLR Signaling and P2X7 Receptor

(2009) J. Harder et al.   JOURNAL OF IMMUNOLOGY

IL-18 neutralization ameliorates obstruction-induced epithelial–mesenchymal transition and renal fibrosis

(2009) Ahmad H. Bani-Hani et al.   KIDNEY INTERNATIONAL

Staphylococcus aureus α-Hemolysin Activates the NLRP3-Inflammasome in Human and Mouse Monocytic Cells

(2009) Robin R. Craven et al.   PLoS One

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malarial Hemozoin Activates the NLRP3 Inflammasome through Lyn and Syk Kinases

(2009) Marina Tiemi Shio et al.   PLoS Pathogens

IL-18 Contributes to Renal Damage after Ischemia-Reperfusion

(2008) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE