Simultaneous activation of innate and adaptive immunity participates in the development of renal injury in a model of heavy proteinuria

NLRP3 inflammasome inhibition ameliorates tubulointerstitial injury in the remnant kidney model

(2018) Orestes Foresto-Neto et al.   LABORATORY INVESTIGATION

Alpha lipoic acid prevents doxorubicin-induced nephrotoxicity by mitigation of oxidative stress, inflammation, and apoptosis in rats

(2017) El-Sayed M. El-Sayed et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

NLRP3 Deficiency Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in a Mouse Unilateral Ureteral Obstruction Model of Chronic Kidney Disease

(2017) Honglei Guo et al.   MEDIATORS OF INFLAMMATION

Innate And Adaptive Immunity are Progressively Activated in Parallel with Renal Injury in the 5/6 Renal Ablation Model

(2017) Camilla Fanelli et al.   Scientific Reports

The JNK Signaling Pathway in Renal Fibrosis

(2017) Keren Grynberg et al.   Frontiers in Physiology

Chronic kidney disease

(2017) Paola Romagnani et al.   Nature Reviews Disease Primers

Rituximab protects podocytes and exerts anti-proteinuric effects in rat adriamycin-induced nephropathy independent of B-lymphocytes

(2016) Yuichi Takahashi et al.   NEPHROLOGY

The NLRP3 inflammasome in kidney disease and autoimmunity

(2016) Holly L Hutton et al.   NEPHROLOGY

T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

(2016) G. Arbore et al.   SCIENCE

Megalin/Cubulin-Lysosome-mediated Albumin Reabsorption Is Involved in the Tubular Cell Activation of NLRP3 Inflammasome and Tubulointerstitial Inflammation

(2015) Dan Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Migratory and Activation Cell Markers of Peripheral Blood Lymphocytes in an Experimental Model of Nephrotic Syndrome

(2015) Wagner de Fátima Pereira et al.   MEDIATORS OF INFLAMMATION

Mycophenolic acid inhibits the phosphorylation of nuclear factor-κB and Akt in renal tubular epithelial cells

(2015) FANG ZENG et al.   Molecular Medicine Reports

Macrophages During the Fibrotic Process: M2 as Friend and Foe

(2015) Tarcio Teodoro Braga et al.   Frontiers in Immunology

The emerging role of the inflammasome in kidney diseases

(2014) Anthony Chang et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species: A novel mechanism of albumin-induced tubulointerstitial inflammation

(2014) Dan Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

NLRP3 Inflammasome Mediates Albumin-induced Renal Tubular Injury through Impaired Mitochondrial Function

(2014) Yibo Zhuang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

Discrete functions of M 2a and M 2c macrophage subsets determine their relative efficacy in treating chronic kidney disease

(2013) Junyu Lu et al.   KIDNEY INTERNATIONAL

Epithelial–mesenchymal transition of renal tubules: Divergent processes of repairing in acute or chronic injury?

(2013) Y.S. Jiang et al.   MEDICAL HYPOTHESES

Canonical and non-canonical effects of the NLRP3 inflammasome in kidney inflammation and fibrosis

(2013) Georg Lorenz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Regression of Albuminuria and Hypertension and Arrest of Severe Renal Injury by a Losartan-Hydrochlorothiazide Association in a Model of Very Advanced Nephropathy

(2013) Simone Costa Alarcon Arias et al.   PLoS One

Involvement of Endoplasmic Reticulum Stress in Albuminuria Induced Inflammasome Activation in Renal Proximal Tubular Cells

(2013) Li Fang et al.   PLoS One

Albumin overload activates intrarenal renin–angiotensin system through protein kinase C and NADPH oxidase-dependent pathway

(2011) Wei Cao et al.   JOURNAL OF HYPERTENSION

The Inflammasomes in Kidney Disease

(2011) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pivotal Role of Toll-Like Receptors 2 and 4, Its Adaptor Molecule MyD88, and Inflammasome Complex in Experimental Tubule-Interstitial Nephritis

(2011) Matheus Correa-Costa et al.   PLoS One

New Roles for Innate Immune Response in Acute and Chronic Kidney Injuries

(2011) G. M. Gonçalves et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Mycophenolic acid inhibits the phosphorylation of NF-κB and JNKs and causes a decrease in IL-8 release in H2O2-treated human renal proximal tubular cells

(2010) Michele Andreucci et al.   CHEMICO-BIOLOGICAL INTERACTIONS

PKC-  Promotes Renal Tubular Cell Apoptosis Associated with Proteinuria

(2010) X. Li et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Toll-Like Receptors and Danger Signaling in Kidney Injury

(2010) H.-J. Anders   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanistic connection between inflammation and fibrosis

(2010) Soo Bong Lee et al.   KIDNEY INTERNATIONAL

Tubular toxicity of proteinuria

(2010) Richard J. Baines et al.   Nature Reviews Nephrology

Toll-like receptors in kidney disease

(2009) Kelly D Smith   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Dynamics of macrophage polarization reveal new mechanism to inhibit IL-1β release through pyrophosphates

(2009) Pablo Pelegrin et al.   EMBO JOURNAL

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

TLR4 Signaling Mediates Inflammation and Tissue Injury in Nephrotoxicity

(2008) B. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of NF-κB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis

(2007) O. Takase et al.   KIDNEY INTERNATIONAL