Pattern recognition receptors and the inflammasome in kidney disease

Nlrp3 Prevents Early Renal Interstitial Edema and Vascular Permeability in Unilateral Ureteral Obstruction

(2014) Wilco P. Pulskens et al.   PLoS One

Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody

(2013) M Reilly et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Renal Protective Effects of Toll-like Receptor 4 Signaling Blockade in Type 2 Diabetic Mice

(2013) J. J. Cha et al.   ENDOCRINOLOGY

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Mechanisms of NOD-like Receptor-Associated Inflammasome Activation

(2013) Haitao Wen et al.   IMMUNITY

ATP-P2X4 signaling mediates NLRP3 inflammasome activation: A novel pathway of diabetic nephropathy

(2013) Kehong Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Effect of Eritoran, an Antagonist of MD2-TLR4, on Mortality in Patients With Severe Sepsis

(2013) Steven M. Opal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Macrophage Phenotype Controls Long-Term AKI Outcomes--Kidney Regeneration versus Atrophy

(2013) M. Lech et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A crystal-clear mechanism of chronic kidney disease

(2013) Christian Kurts   KIDNEY INTERNATIONAL

Human renal stem/progenitor cells repair tubular epithelial cell injury through TLR2-driven inhibin-A and microvesicle-shuttled decorin

(2013) Fabio Sallustio et al.   KIDNEY INTERNATIONAL

NOD-like and Toll-like receptors or inflammasomes contribute to kidney disease in a canonical and a non-canonical manner

(2013) Hans-Joachim Anders et al.   KIDNEY INTERNATIONAL

NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy

(2013) Pengchao Du et al.   KIDNEY INTERNATIONAL

What can tubular progenitor cultures teach us about kidney regeneration?

(2013) Paola Romagnani et al.   KIDNEY INTERNATIONAL

NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy

(2013) Felix Knauf et al.   KIDNEY INTERNATIONAL

The TLR4 antagonist CRX-526 protects against advanced diabetic nephropathy

(2013) Miao Lin et al.   KIDNEY INTERNATIONAL

Nlrp3 is a key modulator of diet-induced nephropathy and renal cholesterol accumulation

(2013) Pieter J. Bakker et al.   KIDNEY INTERNATIONAL

Molecular mechanisms of crystal-related kidney inflammation and injury. Implications for cholesterol embolism, crystalline nephropathies and kidney stone disease

(2013) S. R. Mulay et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Genetic Polymorphisms in Toll-Like Receptors among Pediatric Patients with Renal Parenchymal Infections of Different Clinical Severities

(2013) Chi-Hui Cheng et al.   PLoS One

Allopurinol, quercetin and rutin ameliorate renal NLRP3 inflammasome activation and lipid accumulation in fructose-fed rats

(2012) Qing-Hua Hu et al.   BIOCHEMICAL PHARMACOLOGY

Exacerbation of diabetic nephropathy by hyperlipidaemia is mediated by Toll-like receptor 4 in mice

(2012) T. Kuwabara et al.   DIABETOLOGIA

Preventing urinary tract infection: progress toward an effectiveEscherichia colivaccine

(2012) Ariel R Brumbaugh et al.   Expert Review of Vaccines

Activation of Nod-Like Receptor Protein 3 Inflammasomes Turns on Podocyte Injury and Glomerular Sclerosis in Hyperhomocysteinemia

(2012) Chun Zhang et al.   HYPERTENSION

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

The Toll Interleukin-1 Receptor (IL-1R) 8/Single Ig Domain IL-1R-Related Molecule Modulates the Renal Response to Bacterial Infection

(2012) Jaklien C. Leemans et al.   INFECTION AND IMMUNITY

Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion

(2012) Shrikant R. Mulay et al.   JOURNAL OF CLINICAL INVESTIGATION

Prevention of acute kidney injury in a rodent model of cirrhosis following selective gut decontamination is associated with reduced renal TLR4 expression

(2012) Naina Shah et al.   JOURNAL OF HEPATOLOGY

Inflammasome-Independent NLRP3 Augments TGF-  Signaling in Kidney Epithelium

(2012) W. Wang et al.   JOURNAL OF IMMUNOLOGY

TLR Signaling and DNA Repair: Are They Associated?

(2012) Erin Harberts et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Absence of MyD88 Signaling Induces Donor-Specific Kidney Allograft Tolerance

(2012) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Histones from Dying Renal Cells Aggravate Kidney Injury via TLR2 and TLR4

(2012) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Uromodulin Triggers IL-1 -Dependent Innate Immunity via the NLRP3 Inflammasome

(2012) M. N. Darisipudi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A novel pathogenetic concept—antiviral immunity in lupus nephritis

(2012) Adriana Migliorini et al.   Nature Reviews Nephrology

Toll-Like Receptor 4 in Experimental Kidney Transplantation: Early Mediator of Endogenous Danger Signals

(2012) Tobias Bergler et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Quercetin and Allopurinol Ameliorate Kidney Injury in STZ-Treated Rats with Regulation of Renal NLRP3 Inflammasome Activation and Lipid Accumulation

(2012) Chuang Wang et al.   PLoS One

TLR2, TLR4 and the MYD88 Signaling Pathway Are Crucial for Neutrophil Migration in Acute Kidney Injury Induced by Sepsis

(2012) Angela Castoldi et al.   PLoS One

TLR4 mRNA Levels as Tools to Estimate Risk for Early Posttransplantation Kidney Graft Dysfunction

(2012) Vinicius Andrade-Oliveira et al.   TRANSPLANTATION

The Functional Polymorphism Ala258Ser in the Innate Receptor Gene Ficolin-2 in the Donor Predicts Improved Renal Transplant Outcome

(2012) Michael Eikmans et al.   TRANSPLANTATION

Mice, men and the relatives: cross-species studies underpin innate immunity

(2012) C. E. Bryant et al.   Open Biology

Phenotyping of Nod1/2 double deficient mice and characterization of Nod1/2 in systemic inflammation and associated renal disease

(2012) I. Stroo et al.   Biology Open

Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus

(2011) M. Lech et al.   ANNALS OF THE RHEUMATIC DISEASES

Knockout of Toll-Like Receptor-2 Attenuates Both the Proinflammatory State of Diabetes and Incipient Diabetic Nephropathy

(2011) Sridevi Devaraj et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury

(2011) Conrad A. Farrar et al.   FASEB JOURNAL

Epigallocatechin-3-gallate prevents lupus nephritis development in mice via enhancing the Nrf2 antioxidant pathway and inhibiting NLRP3 inflammasome activation

(2011) Pei-Yi Tsai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sensing damage by the NLRP3 inflammasome

(2011) Jaklien C. Leemans et al.   IMMUNOLOGICAL REVIEWS

Poly-IC Preconditioning Protects against Cerebral and Renal Ischemia-Reperfusion Injury

(2011) Amy E B Packard et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A TLR5 Agonist Inhibits Acute Renal Ischemic Failure

(2011) N. Fukuzawa et al.   JOURNAL OF IMMUNOLOGY

RAGE Does Not Contribute to Renal Injury and Damage upon Ischemia/Reperfusion-Induced Injury

(2011) Mark C. Dessing et al.   Journal of Innate Immunity

IRF4 Deficiency Abrogates Lupus Nephritis Despite Enhancing Systemic Cytokine Production

(2011) M. Lech et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Toll-Like Receptor 4 Promotes Tubular Inflammation in Diabetic Nephropathy

(2011) M. Lin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Inflammasomes in Kidney Disease

(2011) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Genetics of innate immunity and UTI susceptibility

(2011) Bryndís Ragnarsdóttir et al.   Nature Reviews Urology

Toll-Like Receptor Signaling and SIGIRR in Renal Fibrosis upon Unilateral Ureteral Obstruction

(2011) Veronika Skuginna et al.   PLoS One

Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1

(2011) Julia Lichtnekert et al.   PLoS One

Pivotal Role of Toll-Like Receptors 2 and 4, Its Adaptor Molecule MyD88, and Inflammasome Complex in Experimental Tubule-Interstitial Nephritis

(2011) Matheus Correa-Costa et al.   PLoS One

New Roles for Innate Immune Response in Acute and Chronic Kidney Injuries

(2011) G. M. Gonçalves et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

A comprehensive genotype–phenotype interaction of different Toll-like receptor variations in a renal transplant cohort

(2010) Bernd Krüger et al.   CLINICAL SCIENCE

TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy

(2010) S.A. Summers et al.   JOURNAL OF AUTOIMMUNITY

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

(2010) A. A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

Nod1 and Nod2 Are Expressed in Human and Murine Renal Tubular Epithelial Cells and Participate in Renal Ischemia Reperfusion Injury

(2010) Alana A. Shigeoka et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptors and Danger Signaling in Kidney Injury

(2010) H.-J. Anders   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

HMGB1 Contributes to Kidney Ischemia Reperfusion Injury

(2010) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TLR4 Promotes Fibrosis but Attenuates Tubular Damage in Progressive Renal Injury

(2010) W. P. Pulskens et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury

(2010) Jianlin Chen et al.   KIDNEY INTERNATIONAL

TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus

(2010) Cristiana Guiducci et al.   NATURE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Intragraft Toll-like receptor profiling in acute renal allograft rejection

(2010) Mark C. Dessing et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis

(2010) H. Machida et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Genetic Polymorphisms and Susceptibility to Parenchymal Renal Infection Among Pediatric Patients

(2010) Chi-Hui Cheng et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Toll-like receptors 2 and 4 in renal ischemia/reperfusion injury

(2010) Krisztina Rusai et al.   PEDIATRIC NEPHROLOGY

Toll-Like Receptor 4 Promoter Polymorphisms: Common TLR4 Variants May Protect against Severe Urinary Tract Infection

(2010) Bryndís Ragnarsdóttir et al.   PLoS One

Association of Toll-Like Receptor 4 Gene Polymorphism and Expression with Urinary Tract Infection Types in Adults

(2010) Xiaolin Yin et al.   PLoS One

MITOCHONDRIAL DNA IS RELEASED BY SHOCK AND ACTIVATES NEUTROPHILS VIA P38 MAP KINASE

(2010) Qin Zhang et al.   SHOCK

Protective Effects of Toll-like Receptor 4 Inhibitor Eritoran on Renal Ischemia-Reperfusion Injury

(2010) M. Liu et al.   TRANSPLANTATION PROCEEDINGS

Mechanisms of Cisplatin Nephrotoxicity

(2010) Ronald P. Miller et al.   Toxins

Toll-like receptor 4 expression is increased in circulating mononuclear cells of patients with immunoglobulin A nephropathy

(2009) R. Coppo et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Recipient Toll-like receptors contribute to chronic graft dysfunction by both MyD88- and TRIF-dependent signaling

(2009) S. Wang et al.   Disease Models & Mechanisms

TLR2 plays a role in the activation of human resident renal stem/progenitor cells

(2009) Fabio Sallustio et al.   FASEB JOURNAL

Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating Toll-like receptor 2 at the glomerular filtration barrier

(2009) Rahul D. Pawar et al.   IMMUNOLOGY

Heat Shock Protein gp96 Interacts with Protein Phosphatase 5 and Controls Toll-like Receptor 2 (TLR2)-mediated Activation of Extracellular Signal-regulated Kinase (ERK) 1/2 in Post-hypoxic Kidney Cells

(2009) Sanae Ben Mkaddem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cutting Edge: TLR-Dependent Viral Recognition Along with Type I IFN Positive Feedback Signaling Masks the Requirement of Viral Replication for IFN-  Production in Plasmacytoid Dendritic Cells

(2009) Y. Kumagai et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptor 4: A Novel Signaling Pathway During Renal Fibrogenesis

(2009) Matthew T. Campbell et al.   JOURNAL OF SURGICAL RESEARCH

Viral RNA and DNA Trigger Common Antiviral Responses in Mesangial Cells

(2009) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Glomerular expression of toll-like receptor-9 in lupus nephritis but not in normal kidneys: implications for the amplification of the inflammatory response

(2009) ED Papadimitraki et al.   LUPUS

The Role of Toll-Like Receptor 2 in Inflammation and Fibrosis during Progressive Renal Injury

(2009) Jaklien C. Leemans et al.   PLoS One

Toll-Like Receptor Polymorphisms and Susceptibility to Urinary Tract Infections in Adult Women

(2009) Thomas R. Hawn et al.   PLoS One

Genetic Variation of the Human Urinary Tract Innate Immune Response and Asymptomatic Bacteriuria in Women

(2009) Thomas R. Hawn et al.   PLoS One

Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

(2009) B. Kruger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contrasted Blood and Intragraft Toll-Like Receptor 4 mRNA Profiles in Operational Tolerance Versus Chronic Rejection in Kidney Transplant Recipients

(2009) Cécile Braudeau et al.   TRANSPLANTATION

Requirement of toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis

(2008) Emina Savarese et al.   ARTHRITIS AND RHEUMATISM

Role of toll-like receptors in tissue repair and tumorigenesis

(2008) S. Rakoff-Nahoum et al.   BIOCHEMISTRY-MOSCOW

NLR, the nucleotide-binding domain leucine-rich repeat containing gene family

(2008) Zhengmao Ye et al.   CURRENT OPINION IN IMMUNOLOGY

The role of innate immunity in autoimmune tissue injury

(2008) Ramanjaneyulu Allam et al.   CURRENT OPINION IN RHEUMATOLOGY

Viral 5′-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses

(2008) Ramanjaneyulu Allam et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases

(2008) Bruce Beutler   IMMUNOLOGICAL REVIEWS

Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens

(2008) Maciej Lech et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR4 Facilitates Translocation of Bacteria across Renal Collecting Duct Cells

(2008) C. Chassin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Toll-Like Receptor 9 Affects Severity of IgA Nephropathy

(2008) H. Suzuki et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TLR4 Signaling Mediates Inflammation and Tissue Injury in Nephrotoxicity

(2008) B. Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

TLR4 Links Podocytes with the Innate Immune System to Mediate Glomerular Injury

(2008) M. C. Banas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Ischemia-Induced Exocytosis of Weibel-Palade Bodies Mobilizes Stem Cells

(2008) M.-C. Kuo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Toll-Like Receptor-4 Coordinates the Innate Immune Response of the Kidney to Renal Ischemia/Reperfusion Injury

(2008) Wilco P. Pulskens et al.   PLoS One

Nod-like proteins in inflammation and disease

(2007) LAM Carneiro et al.   JOURNAL OF PATHOLOGY