The NLRP3 inflammasome in kidney disease and autoimmunity

Involvement of endoplasmic reticulum stress in angiotensin II-induced NLRP3 inflammasome activation in human renal proximal tubular cells in vitro

(2015) Jing Wang et al.   ACTA PHARMACOLOGICA SINICA

NLRP3 at the interface of metabolism and inflammation

(2015) Moritz Haneklaus et al.   IMMUNOLOGICAL REVIEWS

Renal participation of myeloperoxidase in antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis

(2015) Kim M. O’Sullivan et al.   KIDNEY INTERNATIONAL

Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy

(2015) Khurrum Shahzad et al.   KIDNEY INTERNATIONAL

Taming the inflammasome

(2015) Maayan Levy et al.   NATURE MEDICINE

Hyperuricemia-induced inflammasome and kidney diseases

(2015) Yoshitaka Isaka et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Urate lowering therapy to improve renal outcomes in patients with chronic kidney disease: systematic review and meta-analysis

(2015) Tahir Kanji et al.   BMC Nephrology

Innate IL-17A–Producing Leukocytes Promote Acute Kidney Injury via Inflammasome and Toll-Like Receptor Activation

(2014) Amy J. Chan et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-1 Blockade in Autoinflammatory Syndromes

(2014) Adriana A. Jesus et al.   Annual Review of Medicine

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

The inflammasome and lupus

(2014) J. Michelle Kahlenberg et al.   CURRENT OPINION IN RHEUMATOLOGY

Activation of the Nlrp3 inflammasome by mitochondrial reactive oxygen species: A novel mechanism of albumin-induced tubulointerstitial inflammation

(2014) Dan Liu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Beyond Tissue Injury--Damage-Associated Molecular Patterns, Toll-Like Receptors, and Inflammasomes Also Drive Regeneration and Fibrosis

(2014) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

P2X7Blockade Attenuates Murine Lupus Nephritis by Inhibiting Activation of the NLRP3/ASC/Caspase 1 Pathway

(2013) Jijun Zhao et al.   ARTHRITIS AND RHEUMATISM

Sustained Inflammasome Activity in Macrophages Impairs Wound Healing in Type 2 Diabetic Humans and Mice

(2013) R. E. Mirza et al.   DIABETES

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

AIM2 Facilitates the Apoptotic DNA-induced Systemic Lupus Erythematosus via Arbitrating Macrophage Functional Maturation

(2013) Weijuan Zhang et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Self Double-Stranded (ds)DNA Induces IL-1  Production from Human Monocytes by Activating NLRP3 Inflammasome in the Presence of Anti-dsDNA Antibodies

(2013) M. S. Shin et al.   JOURNAL OF IMMUNOLOGY

Unsaturated fatty acids prevent activation of NLRP3 inflammasome in human monocytes/macrophages

(2013) Laurent L'homme et al.   JOURNAL OF LIPID RESEARCH

The HLA-DRB1*15:01-Restricted Goodpasture's T Cell Epitope Induces GN

(2013) J. D. Ooi et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy

(2013) Felix Knauf et al.   KIDNEY INTERNATIONAL

Molecular mechanisms of crystal-related kidney inflammation and injury. Implications for cholesterol embolism, crystalline nephropathies and kidney stone disease

(2013) S. R. Mulay et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Interleukin-1β in innate inflammation, autophagy and immunity

(2013) Leo A.B. Joosten et al.   SEMINARS IN IMMUNOLOGY

Interleukin-18, more than a Th1 cytokine

(2013) Daniela Novick et al.   SEMINARS IN IMMUNOLOGY

An Essential Role of Caspase 1 in the Induction of Murine Lupus and Its Associated Vascular Damage

(2013) J. Michelle Kahlenberg et al.   Arthritis & Rheumatology

NADPH Oxidase-Mediated Triggering of Inflammasome Activation in Mouse Podocytes and Glomeruli During Hyperhomocysteinemia

(2012) Justine M. Abais et al.   ANTIOXIDANTS & REDOX SIGNALING

Polimorphisms in Inflammasome Genes Are Involved in the Predisposition to Systemic Lupus Erythematosus

(2012) Alessandra Pontillo et al.   AUTOIMMUNITY

Autoinflammation and autoimmunity: Bridging the divide

(2012) A. Doria et al.   AUTOIMMUNITY REVIEWS

Activation of Nod-Like Receptor Protein 3 Inflammasomes Turns on Podocyte Injury and Glomerular Sclerosis in Hyperhomocysteinemia

(2012) Chun Zhang et al.   HYPERTENSION

Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion

(2012) Shrikant R. Mulay et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophil Extracellular Trap-Associated Protein Activation of the NLRP3 Inflammasome Is Enhanced in Lupus Macrophages

(2012) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis

(2012) Simona Deplano et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil Serine Proteases Promote IL-1  Generation and Injury in Necrotizing Crescentic Glomerulonephritis

(2012) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Kidney-infiltrating CD4+ T-cell clones promote nephritis in lupus-prone mice

(2012) Akiko Okamoto et al.   KIDNEY INTERNATIONAL

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

(2012) Haitao Wen et al.   NATURE IMMUNOLOGY

The immunodominant myeloperoxidase T-cell epitope induces local cell-mediated injury in antimyeloperoxidase glomerulonephritis

(2012) J. D. Ooi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-neutrophil cytoplasmic antibody-associated systemic vasculitis: nature or nurture?

(2011) P. A. Gatenby   INTERNAL MEDICINE JOURNAL

The Inflammasomes in Kidney Disease

(2011) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Anti-GBM Glomerulonephritis Involves IL-1 but Is Independent of NLRP3/ASC Inflammasome-Mediated Activation of Caspase-1

(2011) Julia Lichtnekert et al.   PLoS One

Th1 and Th17 cells

(2010) Jesse M. Damsker et al.   Annals of the New York Academy of Sciences

Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis

(2010) Shaun A. Summers et al.   ARTHRITIS AND RHEUMATISM

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

(2010) A. Vilaysane et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mediators of Inflammation in Acute Kidney Injury

(2010) Ali Akcay et al.   MEDIATORS OF INFLAMMATION

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

IL-1 pathways in inflammation and human diseases

(2010) Cem Gabay et al.   Nature Reviews Rheumatology

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Th1 and Th17 Cells Induce Proliferative Glomerulonephritis

(2009) S. A. Summers et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

IL-18 neutralization ameliorates obstruction-induced epithelial–mesenchymal transition and renal fibrosis

(2009) Ahmad H. Bani-Hani et al.   KIDNEY INTERNATIONAL

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis

(2009) Lynelle K. Jones et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Infection and vasculitis

(2009) C. C. Belizna et al.   RHEUMATOLOGY

Deletion of IL-18 receptor ameliorates renal injury in bovine serum albumin-induced glomerulonephritis

(2008) Masafumi Sugiyama et al.   CLINICAL IMMUNOLOGY

IL-18 Contributes to Renal Damage after Ischemia-Reperfusion

(2008) H. Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Elevated Uric Acid Increases the Risk for Kidney Disease

(2008) R. P. Obermayr et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

Biomarkers for the diagnosis and risk stratification of acute kidney injury: A systematic review

(2007) S.G. Coca et al.   KIDNEY INTERNATIONAL