The structure of human CST reveals a decameric assembly bound to telomeric DNA

Benchmarking fold detection by DaliLite v.5

(2019) Liisa Holm   BIOINFORMATICS

Mammalian CST averts replication failure by preventing G-quadruplex accumulation

(2019) Miaomiao Zhang et al.   NUCLEIC ACIDS RESEARCH

Emerging roles of CST in maintaining genome stability and human disease

(2018) Jason A Stewart   Frontiers in Bioscience-Landmark

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Protection of telomeres 1 proteins POT1a and POT1b can repress ATR signaling by RPA exclusion, but binding to CST limits ATR repression by POT1b

(2018) Katja Kratz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

53BP1–RIF1–shieldin counteracts DSB resection through CST- and Polα-dependent fill-in

(2018) Zachary Mirman et al.   NATURE

Reducing effects of particle adsorption to the air–water interface in cryo-EM

(2018) Alex J. Noble et al.   NATURE METHODS

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

A Bayesian approach to beam-induced motion correction in cryo-EM single-particle analysis

(2018) Jasenko Zivanov et al.   IUCrJ

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Addressing preferred specimen orientation in single-particle cryo-EM through tilting

(2017) Yong Zi Tan et al.   NATURE METHODS

Structural and functional analysis of an OB-fold in human Ctc1 implicated in telomere maintenance and bone marrow syndromes

(2017) Prashanth K Shastrula et al.   NUCLEIC ACIDS RESEARCH

Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST

(2017) Anukana Bhattacharjee et al.   NUCLEIC ACIDS RESEARCH

Subunit conformational variation within individual GroEL oligomers resolved by Cryo-EM

(2017) Soung-Hun Roh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MolProbity: More and better reference data for improved all-atom structure validation

(2017) Christopher J. Williams et al.   PROTEIN SCIENCE

Resolution advances in cryo-EM enable application to drug discovery

(2016) Sriram Subramaniam et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication Stress

(2016) Megan Chastain et al.   Cell Reports

Structure and function of the telomeric CST complex

(2016) Cory Rice et al.   Computational and Structural Biotechnology Journal

The Telomere Binding Protein Cdc13 and the Single-Stranded DNA Binding Protein RPA Protect Telomeric DNA from Resection by Exonucleases

(2015) Matthew Greetham et al.   JOURNAL OF MOLECULAR BIOLOGY

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

Semi-automated selection of cryo-EM particles in RELION-1.3

(2015) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

EMRinger: side chain–directed model and map validation for 3D cryo-electron microscopy

(2015) Benjamin A Barad et al.   NATURE METHODS

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

The Tetrahymena telomerase p75–p45–p19 subcomplex is a unique CST complex

(2015) Bingbing Wan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions

(2015) J. Jiang et al.   SCIENCE

The Tetrahymena telomerase p75–p45–p19 subcomplex is a unique CST complex

(2015) Bingbing Wan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sampling the conformational space of the catalytic subunit of human γ-secretase

(2015) Xiao-chen Bai et al.   eLife

Human CST abundance determines recovery from diverse forms of DNA damage and replication stress

(2014) Feng Wang et al.   CELL CYCLE

Optimized Negative Staining: a High-throughput Protocol for Examining Small and Asymmetric Protein Structure by Electron Microscopy

(2014) Matthew Rames et al.   Jove-Journal of Visualized Experiments

Functional characterization of human CTC1 mutations reveals novel mechanisms responsible for the pathogenesis of the telomere disease Coats plus

(2013) Peili Gu et al.   AGING CELL

Molecular basis of telomere syndrome caused by CTC1 mutations

(2013) L.-Y. Chen et al.   GENES & DEVELOPMENT

Structure of the Human Telomeric Stn1-Ten1 Capping Complex

(2013) Christopher Bryan et al.   PLoS One

The Telomere Capping Complex CST Has an Unusual Stoichiometry, Makes Multipartite Interaction with G-Tails, and Unfolds Higher-Order G-Tail Structures

(2013) Neal F. Lue et al.   PLoS Genetics

CST for the grand finale of telomere replication

(2013) Liuh-Yow Chen et al.   Nucleus

Human CST promotes telomere duplex replication and general replication restart after fork stalling

(2012) Jason A Stewart et al.   EMBO JOURNAL

Structure and conformational change of a replication protein A heterotrimer bound to ssDNA

(2012) J. Fan et al.   GENES & DEVELOPMENT

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

The human CST complex is a terminator of telomerase activity

(2012) Liuh-Yow Chen et al.   NATURE

Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus

(2012) Beverley H Anderson et al.   NATURE GENETICS

An emerging role for the conserved telomere component 1 (CTC1) in human genetic disease

(2012) Mary Armanios   PEDIATRIC BLOOD & CANCER

Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-In

(2012) Feng Wang et al.   Cell Reports

Flexible tethering of primase and DNA Pol α in the eukaryotic primosome

(2011) Rafael Núñez-Ramírez et al.   NUCLEIC ACIDS RESEARCH

Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA

(2011) Z. Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A DNA Polymerase-α·Primase Cofactor with Homology to Replication Protein A-32 Regulates DNA Replication in Mammalian Cells

(2009) Darren E. Casteel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway

(2009) Yasuyuki Miyake et al.   MOLECULAR CELL

Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher Eukaryotes

(2009) Yulia V. Surovtseva et al.   MOLECULAR CELL