Dynamic DNA binding, junction recognition and G4 melting activity underlie the telomeric and genome-wide roles of human CST

A practical guide to studying G-quadruplex structures using single-molecule FRET

(2017) Parastoo Maleki et al.   MOLECULAR GENETICS AND GENOMICS

CTC1-mediated C-strand fill-in is an essential step in telomere length maintenance

(2017) Xuyang Feng et al.   NUCLEIC ACIDS RESEARCH

Solving the Telomere Replication Problem

(2017) Laetitia Maestroni et al.   Genes

PrimPol—Prime Time to Reprime

(2017) Thomas Guilliam et al.   Genes

Mutations inSTN1cause Coats plus syndrome and are associated with genomic and telomere defects

(2016) Amos J. Simon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells

(2016) Davide Schiavone et al.   MOLECULAR CELL

Dynamic binding of replication protein a is required for DNA repair

(2016) Ran Chen et al.   NUCLEIC ACIDS RESEARCH

Protein dynamics of human RPA and RAD51 on ssDNA during assembly and disassembly of the RAD51 filament

(2016) Chu Jian Ma et al.   NUCLEIC ACIDS RESEARCH

Simultaneous single-molecule epigenetic imaging of DNA methylation and hydroxymethylation

(2016) Chun-Xiao Song et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-Quadruplexes in DNA Replication: A Problem or a Necessity?

(2016) Anne-Laure Valton et al.   TRENDS IN GENETICS

Human CST Facilitates Genome-wide RAD51 Recruitment to GC-Rich Repetitive Sequences in Response to Replication Stress

(2016) Megan Chastain et al.   Cell Reports

STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function

(2016) Anukana Bhattacharjee et al.   PLoS Genetics

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

BLM unfolds G-quadruplexes in different structural environments through different mechanisms

(2015) Wen-Qiang Wu et al.   NUCLEIC ACIDS RESEARCH

G-quadruplexes and their regulatory roles in biology

(2015) Daniela Rhodes et al.   NUCLEIC ACIDS RESEARCH

Complex interactions between the DNA-damage response and mammalian telomeres

(2015) Nausica Arnoult et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Replication protein A: Single-stranded DNA's first responder

(2014) Ran Chen et al.   BIOESSAYS

Human CST abundance determines recovery from diverse forms of DNA damage and replication stress

(2014) Feng Wang et al.   CELL CYCLE

Metabolism of DNA secondary structures at the eukaryotic replication fork

(2014) Ana María León-Ortiz et al.   DNA REPAIR

Diffusion of Human Replication Protein A along Single-Stranded DNA

(2014) Binh Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

G-quadruplex conformation and dynamics are determined by loop length and sequence

(2014) Ramreddy Tippana et al.   NUCLEIC ACIDS RESEARCH

Concentration-Dependent Exchange of Replication Protein A on Single-Stranded DNA Revealed by Single-Molecule Imaging

(2014) Bryan Gibb et al.   PLoS One

G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding

(2014) S. Ray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The CDC13-STN1-TEN1 complex stimulates Pol α activity by promoting RNA priming and primase-to-polymerase switch

(2014) Neal F. Lue et al.   Nature Communications

Molecular basis of telomere syndrome caused by CTC1 mutations

(2013) L.-Y. Chen et al.   GENES & DEVELOPMENT

Human TEN1 Maintains Telomere Integrity and Functions in Genome-wide Replication Restart

(2013) Christopher Kasbek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Human Telomeric Stn1-Ten1 Capping Complex

(2013) Christopher Bryan et al.   PLoS One

The Telomere Capping Complex CST Has an Unusual Stoichiometry, Makes Multipartite Interaction with G-Tails, and Unfolds Higher-Order G-Tail Structures

(2013) Neal F. Lue et al.   PLoS Genetics

Human Stn1 protects telomere integrity by promoting efficient lagging-strand synthesis at telomeres and mediating C-strand fill-in

(2012) Chenhui Huang et al.   CELL RESEARCH

Human CST promotes telomere duplex replication and general replication restart after fork stalling

(2012) Jason A Stewart et al.   EMBO JOURNAL

Structure and conformational change of a replication protein A heterotrimer bound to ssDNA

(2012) J. Fan et al.   GENES & DEVELOPMENT

Mutations in the telomere capping complex in bone marrow failure and related syndromes

(2012) A. J. Walne et al.   HAEMATOLOGICA

Replication Protein A Unfolds G-Quadruplex Structures with Varying Degrees of Efficiency

(2012) Mohammad H. Qureshi et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The human CST complex is a terminator of telomerase activity

(2012) Liuh-Yow Chen et al.   NATURE

A single vesicle-vesicle fusion assay for in vitro studies of SNAREs and accessory proteins

(2012) Jiajie Diao et al.   Nature Protocols

An emerging role for the conserved telomere component 1 (CTC1) in human genetic disease

(2012) Mary Armanios   PEDIATRIC BLOOD & CANCER

POT1-TPP1 Regulates Telomeric Overhang Structural Dynamics

(2012) Helen Hwang et al.   STRUCTURE

Human CST Has Independent Functions during Telomere Duplex Replication and C-Strand Fill-In

(2012) Feng Wang et al.   Cell Reports

Structural anatomy of telomere OB proteins

(2011) Martin P. Horvath   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Xenopus laevisCtc1-Stn1-Ten1 (xCST) Protein Complex Is Involved in Priming DNA Synthesis on Single-stranded DNA Template inXenopusEgg Extract

(2011) Hidenori Nakaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Processive and Distributive Extension of Human Telomeres by Telomerase under Homeostatic and Nonequilibrium Conditions

(2011) Yong Zhao et al.   MOLECULAR CELL

Maintaining the end: Roles of telomere proteins in end-protection, telomere replication and length regulation

(2011) Jason A. Stewart et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

CST Meets Shelterin to Keep Telomeres in Check

(2010) Marie-Josèphe Giraud-Panis et al.   MOLECULAR CELL

Telomere Extension Occurs at Most Chromosome Ends and Is Uncoupled from Fill-In in Human Cancer Cells

(2009) Yong Zhao et al.   CELL

A DNA Polymerase-α·Primase Cofactor with Homology to Replication Protein A-32 Regulates DNA Replication in Mammalian Cells

(2009) Darren E. Casteel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

OB Fold-containing Protein 1 (OBFC1), a Human Homolog of Yeast Stn1, Associates with TPP1 and Is Implicated in Telomere Length Regulation

(2009) Ma Wan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RPA-like Mammalian Ctc1-Stn1-Ten1 Complex Binds to Single-Stranded DNA and Protects Telomeres Independently of the Pot1 Pathway

(2009) Yasuyuki Miyake et al.   MOLECULAR CELL

Conserved Telomere Maintenance Component 1 Interacts with STN1 and Maintains Chromosome Ends in Higher Eukaryotes

(2009) Yulia V. Surovtseva et al.   MOLECULAR CELL

Circular dichroism and conformational polymorphism of DNA

(2009) J. Kypr et al.   NUCLEIC ACIDS RESEARCH

Dynamic Removal of Replication Protein A by Dna2 Facilitates Primer Cleavage during Okazaki Fragment Processing inSaccharomyces cerevisiae

(2008) Jason A. Stewart et al.   JOURNAL OF BIOLOGICAL CHEMISTRY