The αβTCR mechanosensor exploits dynamic ectodomain allostery to optimize its ligand recognition site

Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition

(2019) Peng Wu et al.   MOLECULAR CELL

NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology

(2019) Robert J. Mallis et al.   JOURNAL OF BIOMOLECULAR NMR

Structural basis of assembly of the human T cell receptor–CD3 complex

(2019) De Dong et al.   NATURE

Mechanosensing through immunoreceptors

(2019) Cheng Zhu et al.   NATURE IMMUNOLOGY

MHC binding affects the dynamics of different T-cell receptors in different ways

(2019) Bernhard Knapp et al.   PLoS Computational Biology

The structural basis of T-cell receptor (TCR) activation: An enduring enigma

(2019) Roy A. Mariuzza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monomeric TCRs drive T cell antigen recognition

(2018) Mario Brameshuber et al.   NATURE IMMUNOLOGY

αβ T Cell Receptor Mechanosensing Forces out Serial Engagement

(2018) Yinnian Feng et al.   TRENDS IN IMMUNOLOGY

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding

(2018) Leah V. Sibener et al.   CELL

Peptide–MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites

(2018) Sneha Rangarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations

(2018) Kristine N. Brazin et al.   IMMUNITY

Mechanosensing drives acuity ofαβT-cell recognition

(2017) Yinnian Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

(2017) Vincent C. Luca et al.   SCIENCE

Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing

(2016) Roshni Basu et al.   CELL

Pre-T Cell Receptors (Pre-TCRs) Leverage Vβ Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands

(2016) Dibyendu Kumar Das et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T cell activation requires force generation

(2016) Kenneth H. Hu et al.   JOURNAL OF CELL BIOLOGY

DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity

(2016) Yang Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elastic Energy Partitioning in DNA Deformation and Binding to Proteins

(2015) Xiaojing Teng et al.   ACS Nano

Early T Cell Activation: Integrating Biochemical, Structural, and Biophysical Cues

(2015) Bernard Malissen et al.   Annual Review of Immunology

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

(2015) Jamie Rossjohn et al.   Annual Review of Immunology

Current status and future challenges in T-cell receptor/peptide/MHC molecular dynamics simulations

(2015) B. Knapp et al.   BRIEFINGS IN BIOINFORMATICS

Cytoskeletal forces during signaling activation in Jurkat T-cells

(2015) King Lam Hui et al.   MOLECULAR BIOLOGY OF THE CELL

Pre-TCR ligand binding impacts thymocyte development before αβTCR expression

(2015) Robert J. Mallis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

(2015) Dibyendu Kumar Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination

(2015) Kristine N. Brazin et al.   Frontiers in Immunology

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

Tracking migration during human T cell development

(2014) Joanna Halkias et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Large Scale Characterization of the LC13 TCR and HLA-B8 Structural Landscape in Reaction to 172 Altered Peptide Ligands: A Molecular Dynamics Simulation Study

(2014) Bernhard Knapp et al.   PLoS Computational Biology

A Single Peptide-Major Histocompatibility Complex Ligand Triggers Digital Cytokine Secretion in CD4+ T Cells

(2013) Jun Huang et al.   IMMUNITY

β-Selection-Induced Proliferation Is Required for αβ T Cell Differentiation

(2012) Taras Kreslavsky et al.   IMMUNITY

The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function

(2012) Jia-huai Wang et al.   IMMUNOLOGICAL REVIEWS

Mechanisms of T Cell Development and Transformation

(2011) Ute Koch et al.   Annual Review of Cell and Developmental Biology

Force Generation upon T Cell Receptor Engagement

(2011) Julien Husson et al.   PLoS One

Structural Basis for Mechanical Force Regulation of the Adhesin FimH via Finger Trap-like β Sheet Twisting

(2010) Isolde Le Trong et al.   CELL

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

The catch bond mechanism between von Willebrand factor and platelet surface receptors investigated by molecular dynamics simulations

(2010) Gianluca Interlandi et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Biophysics of Catch Bonds

(2008) Wendy E. Thomas et al.   Annual Review of Biophysics

The Structural Dynamics and Energetics of an Immunodominant T Cell Receptor Are Programmed by Its Vβ Domain

(2008) Jeffrey Ishizuka et al.   IMMUNITY