The structural basis of αβ T-lineage immune recognition: TCR docking topologies, mechanotransduction, and co-receptor function

Receptor Signaling Clusters in the Immune Synapse

(2012) Michael L. Dustin et al.   Annual Review of Biophysics

Mechanosensing in T Lymphocyte Activation

(2012) Edward Judokusumo et al.   BIOPHYSICAL JOURNAL

The Energetic Basis Underpinning T-cell Receptor Recognition of a Super-bulged Peptide Bound to a Major Histocompatibility Complex Class I Molecule

(2012) Yu Chih Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T Cell Receptors are Structures Capable of Initiating Signaling in the Absence of Large Conformational Rearrangements

(2012) Ricardo A. Fernandes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4

(2012) Y. Yin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TCR Mechanobiology: Torques and Tunable Structures Linked to Early T Cell Signaling

(2012) Sun Taek Kim et al.   Frontiers in Immunology

T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex

(2011) Jarrett J. Adams et al.   IMMUNITY

A New Angle on TCR Activation

(2011) Jia-huai Wang et al.   IMMUNITY

Two-Stage Cooperative T Cell Receptor-Peptide Major Histocompatibility Complex-CD8 Trimolecular Interactions Amplify Antigen Discrimination

(2011) Ning Jiang et al.   IMMUNITY

Dynein-Driven Transport of T Cell Receptor Microclusters Regulates Immune Synapse Formation and T Cell Activation

(2011) Akiko Hashimoto-Tane et al.   IMMUNITY

αβ T Cell Receptors that Do Not Undergo Major Histocompatibility Complex-Specific Thymic Selection Possess Antibody-like Recognition Specificities

(2011) Anastasia N. Tikhonova et al.   IMMUNITY

Force Generation upon T Cell Receptor Engagement

(2011) Julien Husson et al.   PLoS One

Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex

(2011) X. X. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Conserved Hydrophobic Patch on Vβ Domains Revealed by TCRβ Chain Crystal Structures: Implications for Pre-TCR Dimerization

(2011) Bo Zhou et al.   Frontiers in Immunology

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

(2010) Konstantina Nika et al.   IMMUNITY

Distinctive CD3 Heterodimeric Ectodomain Topologies Maximize Antigen-Triggered Activation of    T Cell Receptors

(2010) S. T. Kim et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

(2010) Siew Siew Pang et al.   NATURE

Evidence for a functional sidedness to the   TCR

(2010) M. S. Kuhns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD4 and CD8 binding to MHC molecules primarily acts to enhance Lck delivery

(2010) M. N. Artyomov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cytoplasmic Tail of the T Cell Receptor CD3   Subunit Contains a Phospholipid-Binding Motif that Regulates T Cell Functions

(2009) L. M. DeFord-Watts et al.   JOURNAL OF IMMUNOLOGY

Structural Basis of the CD8  /MHC Class I Interaction: Focused Recognition Orients CD8  to a T Cell Proximal Position

(2009) R. Wang et al.   JOURNAL OF IMMUNOLOGY

T cell receptor triggering by force

(2009) Zhengyu Ma et al.   TRENDS IN IMMUNOLOGY

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules

(2008) Shaodong Dai et al.   IMMUNITY

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

(2008) Jennifer D. Stone et al.   IMMUNOLOGY

A permissive geometry model for TCR–CD3 activation

(2008) Susana Minguet et al.   TRENDS IN BIOCHEMICAL SCIENCES

The receptor deformation model of TCR triggering

(2007) Zhengyu Ma et al.   FASEB JOURNAL