Tracking migration during human T cell development

Thymocyte-Dendritic Cell Interactions near Sources of CCR7 Ligands in the Thymic Cortex

(2014) E. Ladi et al.   JOURNAL OF IMMUNOLOGY

A methodology to study chemotaxis in 3-D collagen gels

(2013) Sergio Caserta et al.   AICHE JOURNAL

Dynamics of thymus organogenesis and colonization in early human development

(2013) A. M. Farley et al.   DEVELOPMENT

Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation

(2013) Despina Moshous et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Opposing chemokine gradients control human thymocyte migration in situ

(2013) Joanna Halkias et al.   JOURNAL OF CLINICAL INVESTIGATION

Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients

(2013) M. Weber et al.   SCIENCE

Distinct Temporal Patterns of T Cell Receptor Signaling During Positive Versus Negative Selection in Situ

(2013) H. J. Melichar et al.   Science Signaling

Elimination of Self-Reactive T Cells in the Thymus: A Timeline for Negative Selection

(2013) Ivan Lilyanov Dzhagalov et al.   PLOS BIOLOGY

The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes

(2012) Fan Mou et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of thymus organogenesis and morphogenesis

(2011) J. Gordon et al.   DEVELOPMENT

Autonomous and extrinsic regulation of thymopoiesis inhuman immune system (HIS) mice

(2011) Nicholas D. Huntington et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neural Crest-Derived Pericytes Promote Egress of Mature Thymocytes at the Corticomedullary Junction

(2010) M. A. Zachariah et al.   SCIENCE

Sphingosine-1-phosphate and immune regulation: trafficking and beyond

(2010) Hongbo Chi   TRENDS IN PHARMACOLOGICAL SCIENCES

The thymus microenvironment in regulating thymocyte differentiation

(2010) Jacy Gameiro et al.   Cell Adhesion & Migration

Characterization in vitro and engraftment potential in vivo of human progenitor T cells generated from hematopoietic stem cells

(2009) G. Awong et al.   BLOOD

CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus

(2009) D. A. Zlotoff et al.   BLOOD

CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus

(2009) A. Krueger et al.   BLOOD

Early defects in human T-cell development severely affect distribution and maturation of thymic stromal cells: possible implications for the pathophysiology of Omenn syndrome

(2009) P. L. Poliani et al.   BLOOD

FTY720 (fingolimod) in Multiple Sclerosis: therapeutic effects in the immune and the central nervous system

(2009) Volker Brinkmann   BRITISH JOURNAL OF PHARMACOLOGY

Spatial Mapping of Thymic Stromal Microenvironments Reveals Unique Features Influencing T Lymphoid Differentiation

(2009) Ann V. Griffith et al.   IMMUNITY

Differential Contribution of Chemotaxis and Substrate Restriction to Segregation of Immature and Mature Thymocytes

(2009) Lauren I. Richie Ehrlich et al.   IMMUNITY

Thymic development beyond β-selection requires phosphatidylinositol 3-kinase activation by CXCR4

(2009) Michelle L. Janas et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR4 acts as a costimulator during thymic β-selection

(2009) Paul C Trampont et al.   NATURE IMMUNOLOGY

The impact of negative selection on thymocyte migration in the medulla

(2009) Marie Le Borgne et al.   NATURE IMMUNOLOGY

CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens

(2009) T. Nitta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of human cytokines dramatically improves reconstitution of specific human-blood lineage cells in humanized mice

(2009) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

(2008) Yu Hikosaka et al.   IMMUNITY

Autoantigen-Specific Interactions with CD4+ Thymocytes Control Mature Medullary Thymic Epithelial Cell Cellularity

(2008) Magali Irla et al.   IMMUNITY

Omenn syndrome: Inflammation in leaky severe combined immunodeficiency

(2008) Anna Villa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Clonal deletion of thymocytes can occur in the cortex with no involvement of the medulla

(2008) Tom M. McCaughtry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The actin regulator coronin 1A is mutant in a thymic egress–deficient mouse strain and in a patient with severe combined immunodeficiency

(2008) Lawrence R Shiow et al.   NATURE IMMUNOLOGY

FTY720 therapy exerts differential effects on T cell subsets in multiple sclerosis

(2008) M. Mehling et al.   NEUROLOGY

Human intrathymic development: a selective approach

(2008) J. Plum et al.   Seminars in Immunopathology