The structural basis of T-cell receptor (TCR) activation: An enduring enigma

Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition

(2019) Peng Wu et al.   MOLECULAR CELL

NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology

(2019) Robert J. Mallis et al.   JOURNAL OF BIOMOLECULAR NMR

The TCR is an allosterically regulated macromolecular machinery changing its conformation while working

(2019) Wolfgang W. Schamel et al.   IMMUNOLOGICAL REVIEWS

Electrostatic interactions: From immune receptor assembly to signaling

(2019) Audrey Connolly et al.   IMMUNOLOGICAL REVIEWS

Structural basis of assembly of the human T cell receptor–CD3 complex

(2019) De Dong et al.   NATURE

An ensemble of cryo-EM structures of TRiC reveal its conformational landscape and subunit specificity

(2019) Mingliang Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MHC binding affects the dynamics of different T-cell receptors in different ways

(2019) Bernhard Knapp et al.   PLoS Computational Biology

Solution NMR: A powerful tool for structural and functional studies of membrane proteins in reconstituted environments

(2019) Robbins Puthenveetil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cryo-electron microscopy of membrane proteins

(2018) Nopnithi Thonghin et al.   METHODS

Monomeric TCRs drive T cell antigen recognition

(2018) Mario Brameshuber et al.   NATURE IMMUNOLOGY

The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling

(2018) Kannan Natarajan et al.   Frontiers in Immunology

Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding

(2018) Leah V. Sibener et al.   CELL

Peptide–MHC (pMHC) binding to a human antiviral T cell receptor induces long-range allosteric communication between pMHC- and CD3-binding sites

(2018) Sneha Rangarajan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations

(2018) Kristine N. Brazin et al.   IMMUNITY

Integrating Experiment and Theory to Understand TCR-pMHC Dynamics

(2018) Ashley M. Buckle et al.   Frontiers in Immunology

A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45

(2017) Adam H. Courtney et al.   MOLECULAR CELL

An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role

(2017) Kannan Natarajan et al.   Nature Communications

A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

(2016) Mahima Swamy et al.   IMMUNITY

Initiation of T cell signaling by CD45 segregation at 'close contacts'

(2016) Veronica T Chang et al.   NATURE IMMUNOLOGY

Structures of the EphA2 Receptor at the Membrane: Role of Lipid Interactions

(2016) Matthieu Chavent et al.   STRUCTURE

Early T Cell Activation: Integrating Biochemical, Structural, and Biophysical Cues

(2015) Bernard Malissen et al.   Annual Review of Immunology

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

(2015) Jamie Rossjohn et al.   Annual Review of Immunology

Dynamic Transmission of Protein Allostery without Structural Change: Spatial Pathways or Global Modes?

(2015) Tom C.B. McLeish et al.   BIOPHYSICAL JOURNAL

A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ

(2015) Mark S. Lee et al.   IMMUNITY

Pre-TCR ligand binding impacts thymocyte development before αβTCR expression

(2015) Robert J. Mallis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

(2015) Dibyendu Kumar Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Visualizing transient dark states by NMR spectroscopy

(2015) Nicholas J. Anthis et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination

(2015) Kristine N. Brazin et al.   Frontiers in Immunology

Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling

(2014) Baoyu Liu et al.   CELL

The ensemble nature of allostery

(2014) Hesam N. Motlagh et al.   NATURE

Insights into the initiation of TCR signaling

(2014) Arup K Chakraborty et al.   NATURE IMMUNOLOGY

Diversity and clonal selection in the human T-cell repertoire

(2014) Q. Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Underappreciated Role of Allostery in the Cellular Network

(2013) Ruth Nussinov et al.   Annual Review of Biophysics

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

A Single Peptide-Major Histocompatibility Complex Ligand Triggers Digital Cytokine Secretion in CD4+ T Cells

(2013) Jun Huang et al.   IMMUNITY

Direct single molecule measurement of TCR triggering by agonist pMHC in living primary T cells

(2013) Geoff P O'Donoghue et al.   eLife

The dark energy of proteins comes to light: conformational entropy and its role in protein function revealed by NMR relaxation

(2012) A Joshua Wand   CURRENT OPINION IN STRUCTURAL BIOLOGY

Piecing together the family portrait of TCR-CD3 complexes

(2012) Michael S. Kuhns et al.   IMMUNOLOGICAL REVIEWS

Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain

(2012) Etienne Gagnon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Evidence for a Dynamically Driven T Cell Signaling Mechanism

(2012) W. F. Hawse et al.   JOURNAL OF IMMUNOLOGY

Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids

(2012) Xiaoshan Shi et al.   NATURE

Protein activity regulation by conformational entropy

(2012) Shiou-Ru Tzeng et al.   NATURE

Force Generation upon T Cell Receptor Engagement

(2011) Julien Husson et al.   PLoS One

Basic residues in the T-cell receptor   cytoplasmic domain mediate membrane association and modulate signaling

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cutting Edge: Mechanical Forces Acting on T Cells Immobilized via the TCR Complex Can Trigger TCR Signaling

(2010) Y. C. Li et al.   JOURNAL OF IMMUNOLOGY

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

(2010) Siew Siew Pang et al.   NATURE

Structural Biology of the T-cell Receptor: Insights into Receptor Assembly, Ligand Recognition, and Initiation of Signaling

(2010) K. W. Wucherpfennig et al.   Cold Spring Harbor Perspectives in Biology

Functional Anatomy of T Cell Activation and Synapse Formation

(2009) David R. Fooksman et al.   Annual Review of Immunology

Antigen Ligation Triggers a Conformational Change within the Constant Domain of the αβ T Cell Receptor

(2009) Travis Beddoe et al.   IMMUNITY

The αβ T Cell Receptor Is an Anisotropic Mechanosensor

(2009) Sun Taek Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic activation of an allosteric regulatory protein

(2009) Shiou-Ru Tzeng et al.   NATURE

Sending Signals Dynamically

(2009) R. G. Smock et al.   SCIENCE

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL