The ensemble nature of allostery

The Underappreciated Role of Allostery in the Cellular Network

(2013) Ruth Nussinov et al.   Annual Review of Biophysics

Investigating Models of Protein Function and Allostery With a Widespread Mutational Analysis of a Light-Activated Protein

(2013) Josiah P. Zayner et al.   BIOPHYSICAL JOURNAL

Solution NMR and Computational Methods for Understanding Protein Allostery

(2013) Gregory Manley et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Modulation of allostery by protein intrinsic disorder

(2013) Allan Chris M. Ferreon et al.   NATURE

NMR paves the way for atomic level descriptions of sparsely populated, transiently formed biomolecular conformers

(2013) A. Sekhar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-allosteric enzyme switches possess larger effector-induced changes in thermodynamic stability than their non-switch analogs

(2013) Jay H. Choi et al.   PROTEIN SCIENCE

A fast approximate method of identifying paths of allosteric communication in proteins

(2013) Burak Erman   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Integrative Structural Biology

(2013) A. B. Ward et al.   SCIENCE

From Sequence and Forces to Structure, Function, and Evolution of Intrinsically Disordered Proteins

(2013) Julie D. Forman-Kay et al.   STRUCTURE

Modulation of Global Low-Frequency Motions Underlies Allosteric Regulation: Demonstration in CRP/FNR Family Transcription Factors

(2013) Thomas L. Rodgers et al.   PLOS BIOLOGY

Biomolecular Simulation: A Computational Microscope for Molecular Biology

(2012) Ron O. Dror et al.   Annual Review of Biophysics

Allostery and the Monod-Wyman-Changeux Model After 50 Years

(2012) Jean-Pierre Changeux   Annual Review of Biophysics

Structural and Energetic Basis of Allostery

(2012) Vincent J. Hilser et al.   Annual Review of Biophysics

Protein Conformational Switches: From Nature to Design

(2012) Jeung-Hoi Ha et al.   CHEMISTRY-A EUROPEAN JOURNAL

The dark energy of proteins comes to light: conformational entropy and its role in protein function revealed by NMR relaxation

(2012) A Joshua Wand   CURRENT OPINION IN STRUCTURAL BIOLOGY

Exploring Residue Component Contributions to Dynamical Network Models of Allostery

(2012) Adam T. VanWart et al.   Journal of Chemical Theory and Computation

Impact of Mutations on the Allosteric Conformational Equilibrium

(2012) Patrick Weinkam et al.   JOURNAL OF MOLECULAR BIOLOGY

Protein activity regulation by conformational entropy

(2012) Shiou-Ru Tzeng et al.   NATURE

Agonism/antagonism switching in allosteric ensembles

(2012) H. N. Motlagh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modelling dynamics in protein crystal structures by ensemble refinement

(2012) B Tom Burnley et al.   eLife

Simulations of allosteric transitions

(2011) Ron Elber   CURRENT OPINION IN STRUCTURAL BIOLOGY

Constructing ensembles for intrinsically disordered proteins

(2011) Charles K Fisher et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Unstructural biology coming of age

(2011) Peter Tompa   CURRENT OPINION IN STRUCTURAL BIOLOGY

Intrinsically disordered proteins from A to Z

(2011) Vladimir N. Uversky   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Allostery in a Disordered Protein: Oxidative Modifications to α-Synuclein Act Distally To Regulate Membrane Binding

(2011) Eva Sevcsik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme

(2011) Lee A Freiburger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Accessing protein conformational ensembles using room-temperature X-ray crystallography

(2011) J. S. Fraser et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allostery in Protein Domains Reflects a Balance of Steric and Hydrophobic Effects

(2011) Jeremy L. England   STRUCTURE

Identifying Conformational States of Macromolecules by Eigen-Analysis of Resampled Cryo-EM Images

(2011) Pawel A. Penczek et al.   STRUCTURE

Changes in Dynamics upon Oligomerization Regulate Substrate Binding and Allostery in Amino Acid Kinase Family Members

(2011) Enrique Marcos et al.   PLoS Computational Biology

Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1

(2010) Bingke Yu et al.   CELL

Allostery and Intrinsic Disorder Mediate Transcription Regulation by Conditional Cooperativity

(2010) Abel Garcia-Pino et al.   CELL

Protein dynamics and allostery: an NMR view

(2010) Shiou-Ru Tzeng et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cyclic Conformational Modification of an Enzyme: Serial Engagement, Energy Relay, Hysteretic Enzyme, and Fischer’s Hypothesis†

(2010) Hong Qian   JOURNAL OF PHYSICAL CHEMISTRY B

The role of conformational entropy in molecular recognition by calmodulin

(2010) Michael S Marlow et al.   Nature Chemical Biology

Conformational Spread as a Mechanism for Cooperativity in the Bacterial Flagellar Switch

(2010) F. Bai et al.   SCIENCE

Frameworks for Understanding Long-Range Intra-Protein Communication

(2009) Matthew Whitley et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The structural basis of allosteric regulation in proteins

(2009) Roman A. Laskowski et al.   FEBS LETTERS

Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms

(2009) Chung-Jung Tsai et al.   Molecular BioSystems

Hidden alternative structures of proline isomerase essential for catalysis

(2009) James S. Fraser et al.   NATURE

Dynamic activation of an allosteric regulatory protein

(2009) Shiou-Ru Tzeng et al.   NATURE

Hidden dynamic allostery in a PDZ domain

(2009) C. M. Petit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The induction of folding cooperativity by ligand binding drives the allosteric response of tetracycline repressor

(2009) Sean E. Reichheld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational modulation of conformational fluctuations in adenylate kinase reveals a local unfolding mechanism for allostery and functional adaptation in proteins

(2009) T. P. Schrank et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sending Signals Dynamically

(2009) R. G. Smock et al.   SCIENCE

Quantitative Determination of the Conformational Properties of Partially Folded and Intrinsically Disordered Proteins Using NMR Dipolar Couplings

(2009) Malene Ringkjøbing Jensen et al.   STRUCTURE

Allosteric Communication Occurs via Networks of Tertiary and Quaternary Motions in Proteins

(2009) Michael D. Daily et al.   PLoS Computational Biology

Allosteric Signaling in the Biotin Repressor Occurs via Local Folding Coupled to Global Dampening of Protein Dynamics

(2008) Olli Laine et al.   JOURNAL OF MOLECULAR BIOLOGY

Visualizing lowly-populated regions of the free energy landscape of macromolecular complexes by paramagnetic relaxation enhancement

(2008) G. Marius Clore   Molecular BioSystems

Visualizing transient events in amino-terminal autoprocessing of HIV-1 protease

(2008) Chun Tang et al.   NATURE

Allostery and cooperativity revisited

(2008) Qiang Cui et al.   PROTEIN SCIENCE

Allostery: an illustrated definition for the ‘second secret of life’

(2008) Aron W. Fenton   TRENDS IN BIOCHEMICAL SCIENCES