Natural compounds with bis-methylene-interrupted Z-double bonds: plant sources, strategies of total synthesis, biological activity, and perspectives

New 1,3-Diynoic Derivatives of Natural Lembehyne B: Stereoselective Synthesis, Anticancer, and Neuritogenic Activity

(2020) Lilya U. Dzhemileva et al.   ACS Omega

Update on the Neurobiology of Vascular Cognitive Impairment: From Lab to Clinic

(2020) Luisa Vinciguerra et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New 1Z,5Z-diene macrodiolides: Catalytic synthesis, anticancer activity, induction of mitochondrial apoptosis, and effect on the cell cycle

(2020) Lilya U. Dzhemileva et al.   BIOORGANIC CHEMISTRY

A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade

(2019) Xiaoxia Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification and Total Synthesis of Two Previously Unreported Odd-Chain Bis-Methylene-Interrupted Fatty Acids with a Terminal Olefin that Activate Protein Phosphatase, Mg2+/Mn2+-Dependent 1A (PPM1A) in Ovaries of the Limpet Cellana toreuma

(2019) Hideki Kawashima et al.   Marine Drugs

Protecting-Group-Free Total Synthesis of Chatenaytrienin-2

(2019) Rupesh A. Kunkalkar et al.   JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis and Antimicrobial Evaluation of 23-Demethyleushearilide and Extensive Antimicrobial Evaluation of All Synthetic Stereoisomers of (16Z,20E)-Eushearilide and (16E,20E)-Eushearilide

(2019) Takayuki Tonoi et al.   MOLECULES

Ti-Catalyzed Cross-Cyclomagnesiation of 1,2-Dienes in the Total Z,Z,Z-Stereoselective Synthesis of Natural Acetogenin–Chatenaytrienin-1

(2019) Vladimir A. D’yakonov et al.   ACS Omega

Stereoselective synthesis and antitumor activity of macrodiolides containing 1Z,5Z-diene and 1,3-diyne moieties

(2019) Vladimir A. D’yakonov et al.   MENDELEEV COMMUNICATIONS

Synthesis of New Cu Complex Based on Natural 5Z,9Z-Eicosadienoic Acid: Effective Topoisomerase I Inhibitor and Cytotoxin against the Cisplatin-Resistant Cell Line

(2019) Lilya U. Dzhemileva et al.   ACS Omega

Forecasting the prevalence of preclinical and clinical Alzheimer's disease in the United States

(2018) Ron Brookmeyer et al.   Alzheimers & Dementia

Organoelement chemistry: promising growth areas and challenges

(2018) G A Abakumov et al.   RUSSIAN CHEMICAL REVIEWS

Catalytic cyclometallation in steroid chemistry V: Synthesis of hybrid molecules based on steroid oximes and (5Z,9Z)-tetradeca-5,9-dienedioic acid as potential anticancer agents

(2018) Vladimir A. D'yakonov et al.   STEROIDS

Catalytic cyclometallation in steroid chemistry VI: Targeted synthesis of hybrid molecules based on steroids and tetradeca-5Z,9Z-diene-1,14-dicarboxylic acid and study of their antitumor activity

(2018) Vladimir A. D'yakonov et al.   STEROIDS

Targeted synthesis of macrodiolides containing bis-methylene-separated Z-double bonds and their antitumor activity in vitro

(2018) Vladimir A. D'yakonov et al.   TETRAHEDRON

Isolation, Synthesis, and Biological Activity of Chlorinated Alkylresorcinols from Dictyostelium Cellular Slime Molds

(2017) Haruhisa Kikuchi et al.   JOURNAL OF NATURAL PRODUCTS

Novel Odd-Chain Fatty Acids with a Terminal Double Bond in Ovaries of the Limpet Cellana toreuma

(2017) Hideki Kawashima et al.   LIPIDS

A new stereoselective synthesis of biologically active di- and trienoic acids containing a (1 Z ,5 Z )-diene moiety

(2017) Vladimir A. D’yakonov et al.   MENDELEEV COMMUNICATIONS

The first total synthesis of lembehyne B

(2017) Vladimir A. D’yakonov et al.   MENDELEEV COMMUNICATIONS

The first total synthesis of the marine acetylenic alcohol, lembehyne B – a selective inducer of early apoptosis in leukemia cancer cells

(2017) Lilya U. Dzhemileva et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ti-catalyzed cross-cyclomagnesiation of 1,2-dienes in the stereoselective synthesis of insect pheromones

(2017) Vladimir A. D'yakonov et al.   TETRAHEDRON LETTERS

The Methylerythritol Phosphate Pathway to Isoprenoids

(2016) Annika Frank et al.   CHEMICAL REVIEWS

Flexible Approach to (5Z,9Z)-Dienoic Fatty Acids Relevant to the Synthesis of Demospongic Acids and Related Natural Products

(2016) Juliane Adrian et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Short Route to the Total Synthesis of Natural Muricadienin and Investigation of Its Cytotoxic Properties

(2016) Usein M. Dzhemilev et al.   JOURNAL OF NATURAL PRODUCTS

Modular and Stereodivergent Approach to Unbranched 1,5,9,n-Polyenes: Total Synthesis of Chatenaytrienin-4

(2016) Juliane Adrian et al.   JOURNAL OF ORGANIC CHEMISTRY

Short and efficient synthetic route to lembehyne B possessing neuritogenic activity

(2016) V. A. D’yakonov et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

The facile first total synthesis of a deuterated analog of natural muricadienin

(2016) Vladimir A. D'yakonov et al.   TETRAHEDRON

A review of the potential health benefits of pine nut oil and its characteristic fatty acid pinolenic acid

(2016) Kayin Xie et al.   Journal of Functional Foods

Stereoselective synthesis of 11-phenylundeca-5Z,9Z-dienoic acid and investigation of its human topoisomerase I and IIα inhibitory activity

(2015) Vladimir A. D’yakonov et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

11-Phenylundeca-5Z,9Z-dienoic Acid: Stereoselective Synthesis and Dual Topoisomerase I/IIα Inhibition

(2015) Vladimir D’yakonov et al.   CURRENT CANCER DRUG TARGETS

Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities

(2015) Soheil Moghadamtousi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Very Long-Chain α-Methoxylated Δ5,9 Fatty Acids from the Sponge Asteropus niger Are Effective Inhibitors of Topoisomerases IB

(2015) Néstor M. Carballeira et al.   LIPIDS

An Unprecedented Occurrence of Δ5,9- and Δ9,15-Dienoic Fatty Acids in Ovaries of the Archaeogastropod Limpet Cellana toreuma

(2015) Hideki Kawashima et al.   LIPIDS

nZ,(n + 4)Z-Dienoic fatty acids: a new method for the synthesis and inhibitory action on topoisomerase I and IIα

(2015) Vladimir A. D’yakonov et al.   MEDICINAL CHEMISTRY RESEARCH

Chiral alkynylcarbinols from marine sponges: asymmetric synthesis and biological relevance

(2015) Dymytrii Listunov et al.   NATURAL PRODUCT REPORTS

Catalytic cyclometallation in steroid chemistry III1Steroids 78 (12–13) (2013) 1298–1303 (http://dx.doi.org/10.1016/j.steroids.2013.09.007).1: Synthesis of steroidal derivatives of 5Z,9Z-dienoic acid and investigation of its human topoisomerase I inhibitory activity

(2015) Vladimir A. D’yakonov et al.   STEROIDS

Total synthesis of (3R,16E,20E,23R)-(−)-eushearilide and structural determination of naturally occurring eushearilide

(2015) Takayuki Tonoi et al.   TETRAHEDRON LETTERS

Lipids and Fatty Acids of Nudibranch Mollusks: Potential Sources of Bioactive Compounds

(2014) Natalia Zhukova   Marine Drugs

Total Synthesis of Muricadienin, the Putative Key Precursor in the Solamin Biosynthesis

(2014) Juliane Adrian et al.   ORGANIC LETTERS

Recent advances in marine drug research

(2013) Saradavey Vinothkumar et al.   BIOTECHNOLOGY ADVANCES

The facile synthesis of the 5Z,9Z-dienoic acids and their topoisomerase I inhibitory activity

(2013) Vladimir A. D'yakonov et al.   CHEMICAL COMMUNICATIONS

Chemistry of the Retinoid (Visual) Cycle

(2013) Philip D. Kiser et al.   CHEMICAL REVIEWS

Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin

(2013) Néstor Carballeira et al.   Marine Drugs

Synthesis and transformations of metallacycles 41. Cyclomagnesiation of O-containing 1,2-dienes with Grignard reagents in the presence of Cp2TiCl2

(2013) V. A. D’yakonov et al.   RUSSIAN CHEMICAL BULLETIN

Novel organomagnesium reagents in synthesis. Catalytic cyclomagnesiation of allenes in the synthesis of N-, O-, and Si-substituted 1Z,5Z-dienes

(2013) Vladimir A. D'yakonov et al.   TETRAHEDRON

Drugging Topoisomerases: Lessons and Challenges

(2012) Yves Pommier   ACS Chemical Biology

Contemporary Challenges in the Design of Topoisomerase II Inhibitors for Cancer Chemotherapy

(2012) Christian Bailly   CHEMICAL REVIEWS

Cyclomagnesiation of nitrogen-containing 1,2-dienes with grignard compounds catalyzed by Cp2TiCl2

(2012) V. A. D’yakonov et al.   RUSSIAN JOURNAL OF ORGANIC CHEMISTRY

Isoprenoids in three-dimensional space: the stereochemistry of terpene biosynthesis

(2011) Jeroen S. Dickschat   NATURAL PRODUCT REPORTS

Pinolenic acid inhibits human breast cancer MDA-MB-231 cell metastasis in vitro

(2010) Szu-Jung Chen et al.   FOOD CHEMISTRY

Pheromone production in bark beetles

(2010) Gary J. Blomquist et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Identification of the Botanical Origin of Pine Nuts Found in Food Products by Gas−Liquid Chromatography Analysis of Fatty Acid Profile

(2010) Frédéric Destaillats et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synthesis of gigantic macrocyclic polyketones through catalytic cyclometalation of cycloalkynes

(2010) Vladimir A. D’yakonov et al.   TETRAHEDRON

Non-methylene-interrupted fatty acids from marine invertebrates: Occurrence, characterization and biological properties

(2009) Gilles Barnathan   BIOCHIMIE

DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial Inhibition

(2009) Yves Pommier   CHEMICAL REVIEWS

Syntheses, Characterizations, and Biological Activities of Tetradeca-4,8-dien-1-yl Acetates as Sex Attractants of Leaf-Mining Moth of the GenusPhyllonorycter(Lepidoptera: Gracillariidae)

(2009) Ilme Liblikas et al.   CHEMISTRY & BIODIVERSITY

Dzhemilev reaction in the synthesis of five-membered sulfur and selenium heterocycles*

(2009) V. A. D’yakonov et al.   Chemistry of Heterocyclic Compounds

Chemical composition of Pinus sibirica nut oils

(2009) Ryszard Zadernowski et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Uptake and Incorporation of Pinolenic Acid Reduces n-6 Polyunsaturated Fatty Acid and Downstream Prostaglandin Formation in Murine Macrophage

(2009) Lu-Te Chuang et al.   LIPIDS

Acetylenic Anticancer Agents

(2008) A. Siddiq et al.   Anti-Cancer Agents in Medicinal Chemistry

Recent progress on the total synthesis of acetogenins from Annonaceae

(2008) Nianguang Li et al.   Beilstein Journal of Organic Chemistry

First total synthesis of (5Z,9Z)-(±)-2-methoxy-5,9-octadecadienoic acid, a marine derived methoxylated analog of taxoleic acid

(2008) Néstor M. Carballeira et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Convergent and Stereoselective Synthesis of TrisubstitutedE-Alkenyl Bromides and Iodides via β-Oxido Phosphonium Ylides

(2008) David M. Hodgson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unusual Fatty Acid Isomers of Triacylglycerols and Polar Lipids in Female Limpet Gonads of Cellana grata

(2008) Hideki Kawashima et al.   LIPIDS

Novel Mg-organic reagents in organic synthesis. Cp2TiCl2 catalyzed intermolecular cyclomagnesiation of cyclic and acyclic 1,2-dienes using Grignard reagents

(2008) Vladimir A. D'yakonov et al.   TETRAHEDRON

New advances in fatty acids as antimalarial, antimycobacterial and antifungal agents

(2007) N.M. Carballeira   PROGRESS IN LIPID RESEARCH