Journal
JOURNAL OF NATURAL PRODUCTS
Volume 80, Issue 10, Pages 2716-2722Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.7b00456
Keywords
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [16H03279]
- Platform Project for Supporting Drug Discovery and Life Science Research - Japan Agency for Medical Research and Development (AMED)
- Shorai Foundation for Science and Technology
- Kobayashi International Scholarship Foundation
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [16H03279] Funding Source: KAKEN
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Eight chlorinated alkylresorcinols, monochasiol A-H (1-8), were isolated from the fruiting bodies of Dictyostelium monochasioides. Compounds 1-8 were synthesized to confirm their structures and to obtain sufficient material for performing biological tests. Monochasiol A (1) selectively inhibited the concanavalin A-induced interleukin-2 production in Jurkat cells, a human T lymphocyte cell line. Monochasiols were biogenetically synthesized by the combination of biosynthetic enzymes relating to the principal polyketides, MPBD and DIF-1, produced by Dictyostelium discoideum.
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