Article
Agricultural Engineering
Jinpeng Wang, Xiao Yu, Kaifeng Wang, Lu Lin, Hu-Hu Liu, Rodrigo Ledesma-Amaro, Xiao-Jun Ji
Summary: This study explored the optimal biosynthetic pathways for customized production of co6-PUFAs in Y. lipolytica and effectively increased the proportions of co6-PUFAs in total fatty acids through various strategies. The customized strains synthesized GLA, DGLA, and ARA with high titers, providing valuable insights into the production of functional co6-PUFAs.
BIORESOURCE TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lizhi Pang, Harshit Shah, Steven Qian, Venkatachalem Sathish
Summary: Instead of directly inhibiting COX-2, the study used a small molecule to reprogram the COX-2 catalyzed omega-6 PUFAs peroxidation in lung cancer cells by inhibiting D5D activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Applied
Svetlana Lyashenko, Maria Jose Gonzalez-Fernandez, Sargilana Borisova, El-Hassan Belarbi, Jose Luis Guil-Guerrero
Summary: This study analyzed seeds from selected Mertensia species for their rich GLA content and minor functional compounds, revealing that Mertensia sibirica and Mertensia maritima spp. asiatica had the highest levels of gamma-linolenic acid. Mertensia sibirica also showed the greatest levels of sterols, phenolics, and tocopherols, making it a potential new source of GLA-rich oils for pharmaceutical and food industries.
Review
Biochemistry & Molecular Biology
Kumar S. D. Kothapalli, Hui Gyu Park, Niharika S. L. Kothapalli, J. Thomas Brenna
Summary: Dysregulation of fatty acid metabolism and de novo lipogenesis, specifically related to FADS2, has been found to drive various cancer types through the production of unsaturated fatty acids. The amplification of the 11q13 locus, where FADS2 is localized, is frequently observed in human cancers. FADS2 dysregulation has been associated with the synthesis of different fatty acids and is linked to tumor growth and survival in colorectal and lung cancer patients.
PROGRESS IN LIPID RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Charlotte Smith Bonde, Louis Bornancin, Yi Lu, Henrik Toft Simonsen, Maria Martinez-Valladares, Miguel Pena-Espinoza, Helena Mejer, Andrew R. Williams, Stig Milan Thamsborg
Summary: The study shows that seaweed can provide bioactive compounds with anti-parasitic activity, with Saccharina latissima and Laminaria digitata showing particularly high anti-parasitic activity. Fatty acids may play an important role in controlling intestinal helminth infections.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Kaori Yokoi, Kenichi Yanagimoto, Kohsuke Hayamizu
Summary: This study investigated the effects of DGLA on pollen-induced allergic symptoms in healthy adults. The results showed that DGLA can reduce sneezing and a blocked nose symptoms associated with pollen allergies.
Article
Biotechnology & Applied Microbiology
Xianghe Meng, Jue Ding, Qin Ye
Summary: This study investigated the one-step preparation of high purity sciadonic acid (SA) using the urea crystallization method assisted by silver ion. The silver ion tied the triunsaturated SA in solution, while the urea crystallization drew the saturated and monounsaturated oleic acid into complexes, resulting in an increase in the purity of SA from 9.95% to 89.3% with a SA recovery of 32%. The optimal purification performances were achieved with a 1:1 silver ion/SA molar ratio. The developed strategy showed stability and acceptable purification performances, making it a simple, economic, and effective method for the preparation of high purity SA.
BIOCHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Applied
Hasan Berk, Murat Kaya, Mert Topcuoglu, Nazli Turkten, Yunus Karatas, Atilla Cihaner
Summary: A series of high sulfur content polymers containing different amounts of fatty acids (oleic acid, linoleic acid, and linolenic acid) was successfully synthesized via inverse vulcanization method and their properties were characterized. The effects of double bonds and free alkyl chains on polysulfur copolymers were systematically investigated. The copolymers with carboxylic acid groups showed solubility in organic solvents, processability, and electroactive properties. Furthermore, the potential applications of these copolymers in dye removal and as cathode materials in Li-S battery were demonstrated.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Multidisciplinary Sciences
Aleksandra Arsic, Predrag Krstic, Marija Paunovic, Jasmina Nedovic, Vladimir Jakovljevic, Vesna Vucic
Summary: This study investigates the anti-inflammatory effects of fish oil and evening primrose oil supplementation in breast cancer patients undergoing chemotherapy. The results show improvements in PUFA status and a decrease in IL-6 levels, suggesting the potential benefits of this treatment in reducing cancer complications.
SCIENTIFIC REPORTS
(2023)
Article
Agriculture, Dairy & Animal Science
Chaiwat Arjin, Chanmany Souphannavong, Rakkiat Norkeaw, Niraporn Chaiwang, Supamit Mekchay, Apinya Sartsook, Maninphan Thongkham, Thanchanok Yosen, Warintorn Ruksiriwanich, Sarana Rose Sommano, Korawan Sringarm
Summary: The supplementation of perilla cake improved pig performance, increased PUFA fatty acids, and decreased the proportion of saturated and unsaturated fatty acids in pork, while not affecting carcass traits and meat quality. This alternative source of raw material can be considered for functional feed additives in livestock production.
Article
Nutrition & Dietetics
Gemma Chiva-Blanch, Oriol Giro, Montserrat Cofan, Alfonso L. Calle-Pascual, Elias Delgado, Ramon Gomis, Amanda Jimenez, Josep Franch-Nadal, Gemma Rojo Martinez, Emilio Ortega
Summary: This study aims to evaluate the association between fatty acids in red blood cell membranes and incident type 2 diabetes in a Spanish population. The results showed that lower percentages of certain fatty acids and higher percentages of others were associated with worse glucose metabolism. Higher percentages of certain fatty acids were also associated with lower risk of diabetes. Dietary patterns rich in vegetables were independently associated with lower risk of glucose regulation deterioration and incident diabetes.
Review
Nutrition & Dietetics
Vanessa N. Cardino, Travis Goeden, William Yakah, Amara E. Ezeamama, Jenifer I. Fenton
Summary: Malnutrition is commonly diagnosed based on abnormal anthropometric parameters related to protein energy malnutrition (PEM), but other contributors such as essential fatty acid deficiency (EFAD) are often overlooked. Previous studies in high-income countries (HICs) have shown that EFAD, characterized by deficiencies in essential fatty acids and their byproducts (HUFAs), can lead to abnormal growth and impaired cognitive development. This review emphasizes the importance of measuring endogenous fatty acid levels to assess fatty acid intake and highlights the potential of EFAD and HUFA scores as biomarkers for overall health and normal development in low-middle-income countries (LMICs).
Article
Biochemistry & Molecular Biology
Robert A. DiSilvestro, Susan Olivo Marston, Autumn Zimmerman, Elizabeth Joseph, Carolynn Boeh McCarty
Summary: Research suggests that GLA may affect resting metabolic rate and help with weight control. However, in overweight young adults with a family history of obesity, borage oil did not affect resting metabolic rate but could improve blood lipid measures.
Article
Biotechnology & Applied Microbiology
Katerina Sukacova, Martin Szotkowski, Petr Paril, Jan Mares, Michal Tous, Daniel Vicha, Marek Polasek, Ivana Marova, Tomas Zavrel
Summary: This study investigates the biotechnological potential of a newly isolated strain of microalga Pseudomuriella engadinensis KASU1 in detail. The strain can survive in drying environments and has the ability to produce unique compounds. It grows rapidly under various conditions and produces essential fatty acids and carotenoids. P. engadinensis shows high potential for nutraceutical production and waste gases treatment.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2023)
Article
Medicine, Research & Experimental
Hongshuai Lv, Weiping Jia, Li Yang, Peng Dong, Jiaojiao Liu, Si Wang, Xiaohai Li, Jinghua Hu, Ling Zhao, Yikang Shi
Summary: This study developed three dual drug conjugates by connecting unsaturated fatty acids with Cabazitaxel on dextran. The conjugates showed enhanced water solubility and antitumor effects, with dextran-GLA-CTX exhibiting the strongest activity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Po-Jung Tsai, Wen-Cheng Huang, Ming-Chi Hsieh, Ping-Jyun Sung, Yueh-Hsiung Kuo, Wen-Huey Wu
Article
Biochemistry & Molecular Biology
Wen-Cheng Huang, Tsung-Hsien Tsai, Ching-Jang Huang, You-Yi Li, Jong-Ho Chyuan, Lu-Te Chuang, Po-Jung Tsai
Article
Biochemistry & Molecular Biology
Tzung-Hsun Tsai, Wen-Cheng Huang, How-Ting Ying, Yueh-Hsiung Kuo, Chien-Chang Shen, Yin-Ku Lin, Po-Jung Tsai
Article
Chemistry, Applied
Tsung-Hsien Tsai, Wen-Cheng Huang, Tsung-Jung Lien, Yu-Han Huang, Hsiang Chang, Chun-Hsien Yu, Po-Jung Tsai
FOOD AND AGRICULTURAL IMMUNOLOGY
(2017)
Article
Chemistry, Applied
Szu-Jung Chen, Hung-Hsing Lin, Wen-Cheng Huang, Po-Jung Tsai, Wen-Ping Chen, Dz-Chi Chen, Lu-Te Chuang
FOOD AND AGRICULTURAL IMMUNOLOGY
(2017)
Article
Cell Biology
Po-Jung Tsai, Mei-Ling Chang, Ching-Mei Hsin, Chung-Chieh Chuang, Lu-Te Chuang, Wen-Huey Wu
MEDIATORS OF INFLAMMATION
(2017)
Article
Biochemistry & Molecular Biology
Tzung-Hsun Tsai, Chun-Hsien Yu, Yu-Ping Chang, Yu-Ting Lin, Ching-Jang Huang, Yueh-Hsiung Kuo, Po-Jung Tsai
Article
Food Science & Technology
Chih-Ling Wang, Wen-Cheng Huang, Cheng-Jen Chou, Mei-Kuang Lu, Ching-Jang Huang, Jason Tsai, Po-Jung Tsai
JOURNAL OF FUNCTIONAL FOODS
(2017)
Article
Cell Biology
Po-Jung Tsai, Wen-Cheng Huang, Shao-Wei Lin, Sung-Nien Chen, Hung-Jing Shen, Hsiang Chang, Lu-Te Chuang
Article
Biochemistry & Molecular Biology
Lu-Te Chuang, Tsung-Hsien Tsai, Tsung-Jung Lien, Wen-Cheng Huang, Jun-Jen Liu, Hsiang Chang, Mei-Ling Chang, Po-Jung Tsai
Article
Cell Biology
Szu-Jung Chen, Wen-Cheng Huang, Hung-Jing Shen, Ruei-Yu Chen, Hsiang Chang, Yun-Shan Ho, Po-Jung Tsai, Lu-Te Chuang
Article
Biochemistry & Molecular Biology
Lu-Te Chuang, Ya-Hsin Shih, Wen-Cheng Huang, Lie-Chwen Lin, Chin Hsu, Jong-Ho Chyuan, Tsung-Hsien Tsai, Po-Jung Tsai
Article
Biochemistry & Molecular Biology
Lu-Te Chuang, Wen-Cheng Huang, Yu-Chen Hou, Jong-Ho Chyuan, Hsiang Chang, Chi- Chang, Tsung-Hsien Tsai, Po-Jung Tsai
Summary: In this study, two cucurbitane-type triterpenoids were evaluated for their suppressive effect on Cutibacterium acnes-induced inflammatory responses. The compounds demonstrated significant inhibitory effects on the production of pro-inflammatory cytokines and reduced ear edema in mice. TCD also showed the ability to suppress the expression of specific proteins, providing further relief from inflammation.
Article
Biochemistry & Molecular Biology
Tzung-Hsun Tsai, Chi- Chang, Ya-Ling Hung, Wen-Cheng Huang, Hsiang Chang, Yueh-Hsiung Kuo, Jong-Ho Chyuan, Lu-Te Chuang, Po-Jung Tsai
Summary: The study identified charantadiol A from bitter melon leaf as a potential anti-inflammatory agent against P. gingivalis-induced inflammation. Charantadiol A effectively reduced the production of pro-inflammatory cytokines and showed inhibitory effects on periodontal inflammation in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Mei-Ling Chang, Yu-Ting Lin, Hsiu-Ni Kung, Yu-Chen Hou, Jun-Jen Liu, Min-Hsiung Pan, Hui-Ling Chen, Chun-Hsien Yu, Po-Jung Tsai
Summary: The triterpenoid-enriched extract (TEE) from bitter melon leaves has a protective effect against carbon tetrachloride (CCl4)-induced hepatic fibrosis in mice, by reducing inflammatory responses and suppressing collagen deposition in liver tissues.