Topoisomerase II contributes to DNA secondary structure-mediated double-stranded breaks

CNCC: an analysis tool to determine genome-wide DNA break end structure at single-nucleotide resolution

(2020) Karol Szlachta et al.   BMC GENOMICS

Pausing sites of RNA polymerase II on actively transcribed genes are enriched with DNA double-stranded breaks

(2020) Sandeep Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppressing proteasome mediated processing of Topoisomerase II DNA-protein complexes preserves genome integrity

(2020) Nicholas Sciascia et al.   eLife

DNA fragility in the parallel evolution of pelvic reduction in stickleback fish

(2019) Kathleen T. Xie et al.   SCIENCE

NBS1 promotes the endonuclease activity of the MRE11‐RAD50 complex by sensing CtIP phosphorylation

(2019) Roopesh Anand et al.   EMBO JOURNAL

Release of paused RNA polymerase II at specific loci favors DNA double-strand-break formation and promotes cancer translocations

(2019) Gaetano Ivan Dellino et al.   NATURE GENETICS

Sequence and Nuclease Requirements for Breakage and Healing of a Structure-Forming (AT)n Sequence within Fragile Site FRA16D

(2019) Simran Kaushal et al.   Cell Reports

Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations

(2019) Henrike Johanna Gothe et al.   MOLECULAR CELL

Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity

(2019) Andres Canela et al.   MOLECULAR CELL

AT-dinucleotide rich sequences drive fragile site formation

(2019) Michal Irony-Tur Sinai et al.   NUCLEIC ACIDS RESEARCH

A nucleotide resolution map of Top2-linked DNA breaks in the yeast and human genome

(2019) William H. Gittens et al.   Nature Communications

Site-Specific Cleavage by Topoisomerase 2: A Mark of the Core Centromere

(2018) Walter Mills et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA replication stress drives fragile site instability

(2018) Michal Irony-Tur Sinai et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Distinct Mechanisms of Nuclease-Directed DNA-Structure-Induced Genetic Instability in Cancer Genomes

(2018) Junhua Zhao et al.   Cell Reports

Transcription and DNA Damage: Holding Hands or Crossing Swords?

(2017) Giuseppina D'Alessandro et al.   JOURNAL OF MOLECULAR BIOLOGY

TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription

(2017) Fernando Gómez-Herreros et al.   Nature Communications

BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks

(2017) Winston X. Yan et al.   Nature Communications

Effects of Replication and Transcription on DNA Structure-Related Genetic Instability

(2017) Guliang Wang et al.   Genes

Permanganate/S1 Nuclease Footprinting Reveals Non-B DNA Structures with Regulatory Potential across a Mammalian Genome

(2017) Fedor Kouzine et al.   Cell Systems

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adducts

(2016) Tomas Aparicio et al.   JOURNAL OF CELL BIOLOGY

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes

(2016) Nguyen Ngoc Hoa et al.   MOLECULAR CELL

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts

(2016) Rajashree A. Deshpande et al.   MOLECULAR CELL

G-quadruplex structures mark human regulatory chromatin

(2016) Robert Hänsel-Hertsch et al.   NATURE GENETICS

DSBCapture: in situ capture and sequencing of DNA breaks

(2016) Stefanie V Lensing et al.   NATURE METHODS

Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

(2016) Yves Pommier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deep sequencing of 10,000 human genomes

(2016) Amalio Telenti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem/progenitor cells

(2016) Bjoern Schwer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

A mechanism for 1,4-Benzoquinone-induced genotoxicity

(2016) Mi Young Son et al.   Oncotarget

Palindrome-Mediated Translocations in Humans: A New Mechanistic Model for Gross Chromosomal Rearrangements

(2016) Hidehito Inagaki et al.   Frontiers in Genetics

Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes

(2015) Ram Madabhushi et al.   CELL

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

(2015) Mihaela Pertea et al.   NATURE BIOTECHNOLOGY

HISAT: a fast spliced aligner with low memory requirements

(2015) Daehwan Kim et al.   NATURE METHODS

Topoisomerase II and leukemia

(2014) MaryJean Pendleton et al.   Annals of the New York Academy of Sciences

Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2·DNA and Top2·RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2)

(2014) Rui Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CtIP Maintains Stability at Common Fragile Sites and Inverted Repeats by End Resection-Independent Endonuclease Activity

(2014) Hailong Wang et al.   MOLECULAR CELL

Defining a personal, allele-specific, and single-molecule long-read transcriptome

(2014) Hagen Tilgner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Analysis of the t(3;8) of hereditary renal cell carcinoma: a palindrome-mediated translocation

(2014) Takema Kato et al.   Cancer Genetics

MUS81-EME2 Promotes Replication Fork Restart

(2014) Alessandra Pepe et al.   Cell Reports

Global Regulation of Promoter Melting in Naive Lymphocytes

(2013) Fedor Kouzine et al.   CELL

The SNM1B/APOLLO DNA nuclease functions in resolution of replication stress and maintenance of common fragile site stability

(2013) Jennifer M. Mason et al.   HUMAN MOLECULAR GENETICS

Role of DNA secondary structures in fragile site breakage along human chromosome 10

(2013) Laura W. Dillon et al.   HUMAN MOLECULAR GENETICS

The MLL recombinome of acute leukemias in 2013

(2013) C Meyer et al.   LEUKEMIA

Replication stress induces specific enrichment of RECQ1 at common fragile sites FRA3B and FRA16D

(2013) Xing Lu et al.   Molecular Cancer

A blooming resolvase at chromosomal fragile sites

(2013) Achille Pellicioli et al.   NATURE CELL BIOLOGY

ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

(2013) Valeria Naim et al.   NATURE CELL BIOLOGY

MUS81 promotes common fragile site expression

(2013) Songmin Ying et al.   NATURE CELL BIOLOGY

Phytochemicals as anticancer and chemopreventive topoisomerase II poisons

(2013) Adam C. Ketron et al.   PHYTOCHEMISTRY REVIEWS

DNA Topoisomerases Participate in Fragility of the Oncogene RET

(2013) Laura W. Dillon et al.   PLoS One

Structure-specific endonucleases: guardians of fragile site stability

(2013) Sheroy Minocherhomji et al.   TRENDS IN CELL BIOLOGY

TDP2–Dependent Non-Homologous End-Joining Protects against Topoisomerase II–Induced DNA Breaks and Genome Instability in Cells and In Vivo

(2013) Fernando Gómez-Herreros et al.   PLoS Genetics

Genome-Wide Screen Reveals Replication Pathway for Quasi-Palindrome Fragility Dependent on Homologous Recombination

(2013) Yu Zhang et al.   PLoS Genetics

The Werner Syndrome Exonuclease Facilitates DNA Degradation and High Fidelity DNA Polymerization by Human DNA Polymerase δ

(2012) Ashwini S. Kamath-Loeb et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA

(2012) K. C. Lee et al.   Biology Open

ViennaRNA Package 2.0

(2011) Ronny Lorenz et al.   Algorithms for Molecular Biology

Non-B DNA-forming Sequences and WRN Deficiency Independently Increase the Frequency of Base Substitution in Human Cells

(2011) Albino Bacolla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

All tangled up: how cells direct, manage and exploit topoisomerase function

(2011) Seychelle M. Vos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TDP2/TTRAP Is the Major 5′-Tyrosyl DNA Phosphodiesterase Activity in Vertebrate Cells and Is Critical for Cellular Resistance to Topoisomerase II-induced DNA Damage

(2010) Zhihong Zeng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secondary structure formation and DNA instability at fragile site FRA16B

(2010) Allison A. Burrow et al.   NUCLEIC ACIDS RESEARCH

CtIP and MRN promote non-homologous end-joining of etoposide-induced DNA double-strand breaks in G1

(2010) Verena Quennet et al.   NUCLEIC ACIDS RESEARCH

Rearrangements of theMLLgene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding

(2009) Hongan Le et al.   GENES CHROMOSOMES & CANCER

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

(2009) Felipe Cortes Ledesma et al.   NATURE

Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair

(2008) Hyun-Min Kim et al.   EMBO JOURNAL

Hairpin structures formed by alpha satellite DNA of human centromeres are cleaved by human topoisomerase II 

(2008) A. T. Jonstrup et al.   NUCLEIC ACIDS RESEARCH