Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations

Published 2019 View Full Article

Authors

Keywords

chromosome translocations, topoisomerases, TOP2, chromosome breaks, MLL, transcription, chromosome organization, torsional stress, DNA topology, supercoiling, cancer

Journal

MOLECULAR CELL

Volume 75, Issue 2, Pages 267-283.e12

Publisher

Elsevier BV

Online

2019-06-12

DOI

10.1016/j.molcel.2019.05.015

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