Effects of Replication and Transcription on DNA Structure-Related Genetic Instability

Effects of ER stress on unfolded protein responses, cell survival, and viral replication in primary effusion lymphoma

(2016) Zenpei Shigemi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

G-quadruplex ligand-induced DNA damage response coupled with telomere dysfunction and replication stress in glioma stem cells

(2016) Daiki Hasegawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Disease-associated repeat instability and mismatch repair

(2016) Monika H.M. Schmidt et al.   DNA REPAIR

DNA replication stress and cancer: cause or cure?

(2016) Elaine M Taylor et al.   Future Oncology

The nature of mutations induced by replication–transcription collisions

(2016) T. Sabari Sankar et al.   NATURE

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human CDK18 promotes replication stress signaling and genome stability

(2016) Giancarlo Barone et al.   NUCLEIC ACIDS RESEARCH

Translocation and deletion breakpoints in cancer genomes are associated with potential non-B DNA-forming sequences

(2016) Albino Bacolla et al.   NUCLEIC ACIDS RESEARCH

Increased global transcription activity as a mechanism of replication stress in cancer

(2016) Panagiotis Kotsantis et al.   Nature Communications

Replication stress: getting back on track

(2016) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sustained E2F-Dependent Transcription Is a Key Mechanism to Prevent Replication-Stress-Induced DNA Damage

(2016) Cosetta Bertoli et al.   Cell Reports

Co-transcriptional R-loops are the main cause of estrogen-induced DNA damage

(2016) Caroline Townsend Stork et al.   eLife

Detection of cis- and trans-acting Factors in DNA Structure-Induced Genetic Instability Using In silico and Cellular Approaches

(2016) Guliang Wang et al.   Frontiers in Genetics

DNA Replication Stress as a Hallmark of Cancer

(2015) Morgane Macheret et al.   Annual Review of Pathology-Mechanisms of Disease

Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients

(2015) Sara Chiker et al.   CELL CYCLE

DNA Secondary Structure at Chromosomal Fragile Sites in Human Disease

(2015) Ryan G. Thys et al.   CURRENT GENOMICS

RPA prevents G-rich structure formation at lagging-strand telomeres to allow maintenance of chromosome ends

(2015) J. Audry et al.   EMBO JOURNAL

Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies

(2015) Jordi Carreras Puigvert et al.   FEBS Journal

Mre11-Sae2 and RPA Collaborate to Prevent Palindromic Gene Amplification

(2015) Sarah K. Deng et al.   MOLECULAR CELL

Experimental phase diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence

(2015) Rifka Vlijm et al.   Nanoscale

Transcription blockage by stable H-DNA analogs in vitro

(2015) Shristi Pandey et al.   NUCLEIC ACIDS RESEARCH

Short Inverted Repeats Are Hotspots for Genetic Instability: Relevance to Cancer Genomes

(2015) Steve Lu et al.   Cell Reports

Three Different Pathways Prevent Chromosome Segregation in the Presence of DNA Damage or Replication Stress in Budding Yeast

(2015) Gloria Palou et al.   PLoS Genetics

R-loops and initiation of DNA replication in human cells: a missing link?

(2015) Rodrigo Lombraña et al.   Frontiers in Genetics

Replication and transcription on a collision course: eukaryotic regulation mechanisms and implications for DNA stability

(2015) Alessandra Brambati et al.   Frontiers in Genetics

Binding polarity of RPA to telomeric sequences and influence of G-quadruplex stability

(2014) Layal Safa et al.   BIOCHIMIE

Replication protein A prevents promiscuous annealing between short sequence homologies: Implications for genome integrity

(2014) Sarah K. Deng et al.   BIOESSAYS

Palindrome-Mediated and Replication-Dependent Pathogenic Structural Rearrangements within theNF1Gene

(2014) Meng-Chang Hsiao et al.   HUMAN MUTATION

Diffusion of Human Replication Protein A along Single-Stranded DNA

(2014) Binh Nguyen et al.   JOURNAL OF MOLECULAR BIOLOGY

Myc and Ras oncogenes engage different energy metabolism programs and evoke distinct patterns of oxidative and DNA replication stress

(2014) Apolinar Maya-Mendoza et al.   Molecular Oncology

Repeat-Associated Non-AUG Translation and Its Impact in Neurodegenerative Disease

(2014) Michael G. Kearse et al.   Neurotherapeutics

Molecular Analysis of a Deletion Hotspot in the NRXN1 Region Reveals the Involvement of Short Inverted Repeats in Deletion CNVs

(2013) Xiaoli Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

Chk1 Inhibits E2F6 Repressor Function in Response to Replication Stress to Maintain Cell-Cycle Transcription

(2013) Cosetta Bertoli et al.   CURRENT BIOLOGY

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

Methods to detect replication-dependent and replication-independent DNA structure-induced genetic instability

(2013) Guliang Wang et al.   METHODS

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Single molecule analysis of Thermus thermophilus SSB protein dynamics on single-stranded DNA

(2013) Jichuan Zhang et al.   NUCLEIC ACIDS RESEARCH

Cdc45 Is a Critical Effector of Myc-Dependent DNA Replication Stress

(2013) Seetha V. Srinivasan et al.   Cell Reports

Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes

(2013) Benoît Le Tallec et al.   Cell Reports

Cell Cycle Regulation of G-Quadruplex DNA Structures at Telomeres

(2012) Stefan A. Juranek et al.   CURRENT PHARMACEUTICAL DESIGN

Transcription as a source of genome instability

(2012) Nayun Kim et al.   NATURE REVIEWS GENETICS

DNA secondary structures: stability and function of G-quadruplex structures

(2012) Matthew L. Bochman et al.   NATURE REVIEWS GENETICS

Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress

(2012) R M Jones et al.   ONCOGENE

Role of DNA Polymerases in Repeat-Mediated Genome Instability

(2012) Kartik A. Shah et al.   Cell Reports

DNA Replication through G-Quadruplex Motifs Is Promoted by the Saccharomyces cerevisiae Pif1 DNA Helicase

(2011) Katrin Paeschke et al.   CELL

Conformational changes of non-B DNA

(2011) Jungkweon Choi et al.   CHEMICAL SOCIETY REVIEWS

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

G-quadruplex formation at the 3' end of telomere DNA inhibits its extension by telomerase, polymerase and unwinding by helicase

(2011) Q. Wang et al.   NUCLEIC ACIDS RESEARCH

Overcoming natural replication barriers: differential helicase requirements

(2011) Ranjith P. Anand et al.   NUCLEIC ACIDS RESEARCH

Cyclin-dependent kinase 9–cyclin K functions in the replication stress response

(2010) David S Yu et al.   EMBO REPORTS

Replication-dependent instability at (CTG)•(CAG) repeat hairpins in human cells

(2010) Guoqi Liu et al.   Nature Chemical Biology

Mechanisms and implications of transcription blockage by guanine-rich DNA sequences

(2010) B. P. Belotserkovskii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G-Quadruplex DNA Sequences Are Evolutionarily Conserved and Associated with Distinct Genomic Features in Saccharomyces cerevisiae

(2010) John A. Capra et al.   PLoS Computational Biology

Non-B DNA structure-induced genetic instability and evolution

(2009) Junhua Zhao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Methods to determine DNA structural alterations and genetic instability

(2009) Guliang Wang et al.   METHODS

Models for chromosomal replication-independent non-B DNA structure-induced genetic instability

(2009) Guliang Wang et al.   MOLECULAR CARCINOGENESIS

dUTP incorporation into genomic DNA is linked to transcription in yeast

(2009) Nayun Kim et al.   NATURE

Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility

(2009) Irina Voineagu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stabilization of quadruplex DNA perturbs telomere replication leading to the activation of an ATR-dependent ATM signaling pathway

(2009) Angela Rizzo et al.   NUCLEIC ACIDS RESEARCH

The G-Quadruplex Ligand Telomestatin Impairs Binding of Topoisomerase IIIα to G-Quadruplex-Forming Oligonucleotides and Uncaps Telomeres in ALT Cells

(2009) Nassima Temime-Smaali et al.   PLoS One

Chromosomal instability mediated by non-B DNA: Cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans

(2008) H. Inagaki et al.   GENOME RESEARCH

DNA Structure-induced Genomic Instability In Vivo

(2008) Guliang Wang et al.   JNCI-Journal of the National Cancer Institute

Inhibitory effect of a short Z-DNA forming sequence on transcription elongation by T7 RNA polymerase

(2008) J. V. Ditlevson et al.   NUCLEIC ACIDS RESEARCH

Stability and kinetics of G-quadruplex structures

(2008) A. N. Lane et al.   NUCLEIC ACIDS RESEARCH

Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins

(2008) I. Voineagu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA