Non-B DNA-forming Sequences and WRN Deficiency Independently Increase the Frequency of Base Substitution in Human Cells

The Werner syndrome protein affects the expression of genes involved in adipogenesis and inflammation in addition to cell cycle and DNA damage responses

(2011) Ramachander V.N. Turaga et al.   CELL CYCLE

Human DHX9 Helicase Unwinds Triple-Helical DNA Structures

(2010) Aklank Jain et al.   BIOCHEMISTRY

WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations

(2010) Katrin Friedrich et al.   HUMAN GENETICS

Complete ascertainment of intragenic copy number mutations (CNMs) in the CFTR gene and its implications for CNM formation at other autosomal loci

(2010) Sylvia Quemener et al.   HUMAN MUTATION

The mutation spectrum revealed by paired genome sequences from a lung cancer patient

(2010) William Lee et al.   NATURE

WRN helicase unwinds Okazaki fragment-like hybrids in a reaction stimulated by the human DHX9 helicase

(2010) Prasun Chakraborty et al.   NUCLEIC ACIDS RESEARCH

HObullet radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases

(2010) F. Bergeron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cruciform-forming inverted repeats appear to have mediated many of the microinversions that distinguish the human and chimpanzee genomes

(2009) Jessica Kolb et al.   CHROMOSOME RESEARCH

Vitamin C restores healthy aging in a mouse model for Werner syndrome

(2009) Laurent Massip et al.   FASEB JOURNAL

Gene conversion causing human inherited disease: Evidence for involvement of non-B-DNA-forming sequences and recombination-promoting motifs in DNA breakage and repair

(2009) Nadia Chuzhanova et al.   HUMAN MUTATION

Models for chromosomal replication-independent non-B DNA structure-induced genetic instability

(2009) Guliang Wang et al.   MOLECULAR CARCINOGENESIS

Human mutation rate associated with DNA replication timing

(2009) John A Stamatoyannopoulos et al.   NATURE GENETICS

Altered gene expression in the Werner and Bloom syndromes is associated with sequences having G-quadruplex forming potential

(2009) Jay E. Johnson et al.   NUCLEIC ACIDS RESEARCH

The Human Gene Mutation Database: 2008 update

(2009) Peter D Stenson et al.   Genome Medicine

Testing hypotheses of aging in long-lived mice of the genus Peromyscus: association between longevity and mitochondrial stress resistance, ROS detoxification pathways, and DNA repair efficiency

(2008) Zoltan Ungvari et al.   AGE

Cigarette Smoke Induces Cellular Senescence via Werner's Syndrome Protein Down-regulation

(2008) Toru Nyunoya et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Influence of Guanine on DNA Hole Transport Efficiency

(2008) Frederick D. Lewis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Roles of the Werner syndrome RecQ helicase in DNA replication

(2008) Julia M. Sidorova   DNA REPAIR

Unexpected complexity at breakpoint junctions in phenotypically normal individuals and mechanisms involved in generating balanced translocations t(1;22)(p36;q13)

(2008) M. Gajecka et al.   GENOME RESEARCH

Chromosomal instability mediated by non-B DNA: Cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans

(2008) H. Inagaki et al.   GENOME RESEARCH

The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis

(2008) Meltem Muftuoglu et al.   HUMAN GENETICS

FANCJ Is a Structure-specific DNA Helicase Associated with the Maintenance of Genomic G/C Tracts

(2008) Timothy B. C. London et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Human RecQ Helicases, BLM and RECQ1, Display Distinct DNA Substrate Specificities

(2008) Venkateswarlu Popuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Werner Syndrome Protein Binds Replication Fork and Holliday Junction DNAs as an Oligomer

(2008) Sarah A. Compton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

EXTENSION OF THE LIFE SPAN IN PATIENTS WITH WERNER SYNDROME

(2008) Koutaro Yokote et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

DNA Structure-induced Genomic Instability In Vivo

(2008) Guliang Wang et al.   JNCI-Journal of the National Cancer Institute

Evidence for a predominant role of oxidative damage in germline mutation in mammals

(2008) Arlin Stoltzfus   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Inhibitory effect of a short Z-DNA forming sequence on transcription elongation by T7 RNA polymerase

(2008) J. V. Ditlevson et al.   NUCLEIC ACIDS RESEARCH

WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand

(2008) Z. Bukowy et al.   NUCLEIC ACIDS RESEARCH

Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance

(2008) V BOHR   TRENDS IN BIOCHEMICAL SCIENCES