Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes

The role of nucleocytoplasmic transport in mechanotransduction

(2019) Elena Kassianidou et al.   EXPERIMENTAL CELL RESEARCH

Nuclear envelope rupture: little holes, big openings

(2018) Emily M .Hatch   CURRENT OPINION IN CELL BIOLOGY

Micropatterning as a tool to identify regulatory triggers and kinetics of actin-mediated endothelial mechanosensing

(2018) Florian A. Gegenfurtner et al.   JOURNAL OF CELL SCIENCE

Emerging views of the nucleus as a cellular mechanosensor

(2018) Tyler J. Kirby et al.   NATURE CELL BIOLOGY

Nuclear pore complexes as hubs for gene regulation

(2018) Maximiliano A. D'Angelo   Nucleus

Nuclear pore complexes as hubs for gene regulation

(2018) Maximiliano A. D'Angelo   Nucleus

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics

(2017) Charles T. Foster et al.   GENES & DEVELOPMENT

Emerging roles of mechanical forces in chromatin regulation

(2017) Yekaterina A. Miroshnikova et al.   JOURNAL OF CELL SCIENCE

Mechanical signals activate p38 MAPK pathway-dependent reinforcement of actin via mechanosensitive HspB1

(2017) Laura Hoffman et al.   MOLECULAR BIOLOGY OF THE CELL

Regulation of genome organization and gene expression by nuclear mechanotransduction

(2017) Caroline Uhler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

LINC complexes and nuclear positioning

(2017) Yin Loon Lee et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Bursting the Bubble – Nuclear Envelope Rupture as a Path to Genomic Instability?

(2017) Pragya Shah et al.   TRENDS IN CELL BIOLOGY

Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology

(2017) Jeong-Ki Kim et al.   Nature Communications

Mechano-adaptation of the stem cell nucleus

(2017) Su-Jin Heo et al.   Nucleus

Separate roles for chromatin and lamins in nuclear mechanics

(2017) Andrew D. Stephens et al.   Nucleus

Mechano-adaptation of the stem cell nucleus

(2017) Su-Jin Heo et al.   Nucleus

Separate roles for chromatin and lamins in nuclear mechanics

(2017) Andrew D. Stephens et al.   Nucleus

Framework to function: mechanosensitive regulators of gene transcription

(2016) Megan Finch-Edmondson et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Function and regulation of the Arp2/3 complex during cell migration in diverse environments

(2016) Kristen F Swaney et al.   CURRENT OPINION IN CELL BIOLOGY

Causes and consequences of nuclear envelope alterations in tumour progression

(2016) Emily S. Bell et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Mechanisms of Hippo pathway regulation

(2016) Zhipeng Meng et al.   GENES & DEVELOPMENT

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Dynamic Encounters of Genes and Transcripts with the Nuclear Pore

(2016) Rakefet Ben-Yishay et al.   TRENDS IN GENETICS

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

(2016) Hawa-Racine Thiam et al.   Nature Communications

The mammalian LINC complex regulates genome transcriptional responses to substrate rigidity

(2016) Samer G. Alam et al.   Scientific Reports

Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells

(2015) Tristan P. Driscoll et al.   BIOPHYSICAL JOURNAL

Growth Control: Re-examining Zyxin’s Role in the Hippo Pathway

(2015) Kieran F. Harvey   CURRENT BIOLOGY

Zyxin Antagonizes the FERM Protein Expanded to Couple F-Actin and Yorkie-Dependent Organ Growth

(2015) Pedro Gaspar et al.   CURRENT BIOLOGY

The 4D nucleome: Evidence for a dynamic nuclear landscape based on co-aligned active and inactive nuclear compartments

(2015) Thomas Cremer et al.   FEBS LETTERS

Nuclear pore proteins and the control of genome functions

(2015) Arkaitz Ibarra et al.   GENES & DEVELOPMENT

Accessorizing and anchoring the LINC complex for multifunctionality

(2015) Wakam Chang et al.   JOURNAL OF CELL BIOLOGY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts

(2015) Wakam Chang et al.   Nucleus

Linker of nucleoskeleton and cytoskeleton (LINC) complex-mediated actin-dependent nuclear positioning orients centrosomes in migrating myoblasts

(2015) Wakam Chang et al.   Nucleus

The regulation of gene expression during onset of differentiation by nuclear mechanical heterogeneity

(2014) Shefali Talwar et al.   BIOMATERIALS

Hippo-Independent Activation of YAP by the GNAQ Uveal Melanoma Oncogene through a Trio-Regulated Rho GTPase Signaling Circuitry

(2014) Xiaodong Feng et al.   CANCER CELL

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Tight coupling between nucleus and cell migration through the perinuclear actin cap

(2014) D.-H. Kim et al.   JOURNAL OF CELL SCIENCE

From Hypothesis to Mechanism: Uncovering Nuclear Pore Complex Links to Gene Expression

(2014) L. T. Burns et al.   MOLECULAR AND CELLULAR BIOLOGY

Actomyosin contractility rotates the cell nucleus

(2014) Abhishek Kumar et al.   Scientific Reports

Super-resolution microscopy reveals LINC complex recruitment at nuclear indentation sites

(2014) Marie Versaevel et al.   Scientific Reports

The regulation of dynamic mechanical coupling between actin cytoskeleton and nucleus by matrix geometry

(2013) Qingsen Li et al.   BIOMATERIALS

Nuclear Positioning

(2013) Gregg G. Gundersen et al.   CELL

A Mechanical Checkpoint Controls Multicellular Growth through YAP/TAZ Regulation by Actin-Processing Factors

(2013) Mariaceleste Aragona et al.   CELL

Chromatin-Bound Xenopus Dppa2 Shapes the Nucleus by Locally Inhibiting Microtubule Assembly

(2013) John Z. Xue et al.   DEVELOPMENTAL CELL

Substratum stiffness and latrunculin B modulate the gene expression of the mechanotransducers YAP and TAZ in human trabecular meshwork cells

(2013) Sara M. Thomasy et al.   EXPERIMENTAL EYE RESEARCH

Protein kinase A activates the Hippo pathway to modulate cell proliferation and differentiation

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Differences in the Nuclear Export Mechanism between Myocardin and Myocardin-related Transcription Factor A

(2013) Ken'ichiro Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin Cytoskeleton Regulates Hippo Signaling

(2013) Pradeep Reddy et al.   PLoS One

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Broken nuclei – lamins, nuclear mechanics, and disease

(2013) Patricia M. Davidson et al.   TRENDS IN CELL BIOLOGY

Mechanical Activation of Cells Induces Chromatin Remodeling Preceding MKL Nuclear Transport

(2012) K. Venkatesan Iyer et al.   BIOPHYSICAL JOURNAL

Arp2/3 complex–dependent actin networks constrain myosin II function in driving retrograde actin flow

(2012) Qing Yang et al.   JOURNAL OF CELL BIOLOGY

Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators

(2012) Laura M. Hoffman et al.   MOLECULAR BIOLOGY OF THE CELL

Transduction of mechanical and cytoskeletal cues by YAP and TAZ

(2012) Georg Halder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells

(2011) Michelangelo Cordenonsi et al.   CELL

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Actomyosin Tension Exerted on the Nucleus through Nesprin-1 Connections Influences Endothelial Cell Adhesion, Migration, and Cyclic Strain-Induced Reorientation

(2010) T.J. Chancellor et al.   BIOPHYSICAL JOURNAL

Nesprins LINC the nucleus and cytoskeleton

(2010) Jason A Mellad et al.   CURRENT OPINION IN CELL BIOLOGY

Hippo signaling: growth control and beyond

(2010) G. Halder et al.   DEVELOPMENT

An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A

(2010) Rafał Pawłowski et al.   EMBO JOURNAL

Nuclear Import Mechanism for Myocardin Family Members and Their Correlation with Vascular Smooth Muscle Cell Phenotype

(2010) Seiji Nakamura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

(2010) G. W. G. Luxton et al.   SCIENCE

Identification and Characterization of a Small Molecule Inhibitor of Formin-Mediated Actin Assembly

(2009) Syed A. Rizvi et al.   CHEMISTRY & BIOLOGY

Mammalian SUN Protein Interaction Networks at the Inner Nuclear Membrane and Their Role in Laminopathy Disease Processes

(2009) Farhana Haque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway

(2009) Jianmin Zhang et al.   NATURE CELL BIOLOGY

A perinuclear actin cap regulates nuclear shape

(2009) Shyam B. Khatau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Shape, Mechanics, and Mechanotransduction

(2008) Kris Noel Dahl et al.   CIRCULATION RESEARCH

Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness

(2008) P.J. Stewart-Hutchinson et al.   EXPERIMENTAL CELL RESEARCH

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY