Emerging roles of mechanical forces in chromatin regulation

The Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction

(2017) Spencer E. Szczesny et al.   JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME

Mechanosensing by the nucleus: From pathways to scaling relationships

(2017) Sangkyun Cho et al.   JOURNAL OF CELL BIOLOGY

Causes and consequences of nuclear gene positioning

(2017) Sigal Shachar et al.   JOURNAL OF CELL SCIENCE

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

Mechanisms and functions of nuclear envelope remodelling

(2017) Rosemarie Ungricht et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells

(2016) Su-Jin Heo et al.   BIOPHYSICAL JOURNAL

A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration

(2016) Xuan Cao et al.   BIOPHYSICAL JOURNAL

RETRACTED: FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis

(2016) Colleen T. Skau et al.   CELL

A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time

(2016) Daeha Seo et al.   CELL

Nuclear constriction segregates mobile nuclear proteins away from chromatin

(2016) Jerome Irianto et al.   MOLECULAR BIOLOGY OF THE CELL

Chromatin Domains: The Unit of Chromosome Organization

(2016) Jesse R. Dixon et al.   MOLECULAR CELL

Tissue mechanics promote IDH1-dependent HIF1α–tenascin C feedback to regulate glioblastoma aggression

(2016) Yekaterina A. Miroshnikova et al.   NATURE CELL BIOLOGY

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

(2016) Huy Quang Le et al.   NATURE CELL BIOLOGY

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression

(2016) Hanane Laklai et al.   NATURE MEDICINE

Chromosome intermingling—the physical basis of chromosome organization in differentiated cells

(2016) Shovamayee Maharana et al.   NUCLEIC ACIDS RESEARCH

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Perinuclear Arp2/3-driven actin polymerization enables nuclear deformation to facilitate cell migration through complex environments

(2016) Hawa-Racine Thiam et al.   Nature Communications

Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity

(2016) Su-Jin Heo et al.   eLife

Under Pressure: Mechanical Stress Management in the Nucleus

(2016) Néjma Belaadi et al.   Cells

Opposite Effects of mGluR1a and mGluR5 Activation on Nucleus Accumbens Medium Spiny Neuron Dendritic Spine Density

(2016) Kellie S. Gross et al.   PLoS One

A thermodynamically motivated model for stress-fiber reorganization

(2015) A. Vigliotti et al.   Biomechanics and Modeling in Mechanobiology

Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells

(2015) Tristan P. Driscoll et al.   BIOPHYSICAL JOURNAL

Chromatin at the nuclear periphery and the regulation of genome functions

(2015) Charlene Lemaître et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Three-dimensional genome architecture: players and mechanisms

(2015) Ana Pombo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Loss of lamin A function increases chromatin dynamics in the nuclear interior

(2015) I. Bronshtein et al.   Nature Communications

Soft viscoelastic properties of nuclear actin age oocytes due to gravitational creep

(2015) Marina Feric et al.   Scientific Reports

On the role of the actin cytoskeleton and nucleus in the biomechanical response of spread cells

(2014) Noel H. Reynolds et al.   BIOMATERIALS

ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress

(2014) Amit Kumar et al.   CELL

Chromatin Repressive Complexes in Stem Cells, Development, and Cancer

(2014) Anne Laugesen et al.   Cell Stem Cell

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

(2014) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Auxetic nuclei in embryonic stem cells exiting pluripotency

(2014) Stefano Pagliara et al.   NATURE MATERIALS

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular mechanosensing: Getting to the nucleus of it all

(2014) Gregory R. Fedorchak et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Chromatin Remodeling at DNA Double-Strand Breaks

(2013) Brendan D. Price et al.   CELL

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

Nuclear Mechanics and Mechanotransduction in Health and Disease

(2013) Philipp Isermann et al.   CURRENT BIOLOGY

Nuclear Envelope Composition Determines the Ability of Neutrophil-type Cells to Passage through Micron-scale Constrictions

(2013) Amy C. Rowat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualization of actin filaments and monomers in somatic cell nuclei

(2013) Brittany J. Belin et al.   MOLECULAR BIOLOGY OF THE CELL

A nuclear F-actin scaffold stabilizes ribonucleoprotein droplets against gravity in large cells

(2013) Marina Feric et al.   NATURE CELL BIOLOGY

To be or not to be assembled: progressing into nuclear actin filaments

(2013) Robert Grosse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins

(2013) J. Seong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lamins regulate cell trafficking and lineage maturation of adult human hematopoietic cells

(2013) J.-W. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Shedding light on nuclear actin dynamics and function

(2013) Richard Treisman   TRENDS IN BIOCHEMICAL SCIENCES

Lamin A/C is Expressed in Pluripotent Mouse Embryonic Stem Cells

(2013) Melanie A. Eckersley-Maslin et al.   Nucleus

Mechanical Regulation of Nuclear Structure and Function

(2012) Rui P. Martins et al.   Annual Review of Biomedical Engineering

Force-Induced Changes in Subnuclear Movement and Rheology

(2012) Elizabeth A. Booth-Gauthier et al.   BIOPHYSICAL JOURNAL

Chromatin Decondensation and Nuclear Softening Accompany Nanog Downregulation in Embryonic Stem Cells

(2012) Kevin J. Chalut et al.   BIOPHYSICAL JOURNAL

Nucleoskeleton mechanics at a glance

(2011) K. N. Dahl et al.   JOURNAL OF CELL SCIENCE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The nucleoskeleton as a genome-associated dynamic 'network of networks'

(2011) Dan N. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE