Micropatterning as a tool to identify regulatory triggers and kinetics of actin-mediated endothelial mechanosensing

Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes

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Contractility as a global regulator of cellular morphology, velocity, and directionality in low-adhesive fibrillary micro-environments

(2016) Simon L. Schuster et al.   BIOMATERIALS

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MRTF potentiates TEAD‐YAP transcriptional activity causing metastasis

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Role of YAP/TAZ in cell-matrix adhesion-mediated signalling and mechanotransduction

(2016) Sirio Dupont   EXPERIMENTAL CELL RESEARCH

Integrins synergise to induce expression of the MRTF-A–SRF target gene ISG15 for promoting cancer cell invasion

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Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

(2016) Kuei-Chun Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atheroprotective laminar flow inhibits Hippo pathway effector YAP in endothelial cells

(2016) Suowen Xu et al.   Translational Research

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3

(2016) Pam Speight et al.   Nature Communications

Cell-cell contact and matrix adhesion promote αSMA expression during TGFβ1-induced epithelial-myofibroblast transition via Notch and MRTF-A

(2016) Joseph W. O’Connor et al.   Scientific Reports

Mechanosignaling in the vasculature: emerging concepts in sensing, transduction and physiological responses

(2015) Shampa Chatterjee et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration

(2015) R. Mateus et al.   DEVELOPMENT

Myocardin-related transcription factors are required for cardiac development and function

(2015) Mayssa H. Mokalled et al.   DEVELOPMENTAL BIOLOGY

YAP promotes proliferation, chemoresistance, and angiogenesis in human cholangiocarcinoma through TEAD transcription factors

(2015) Patricia Marti et al.   HEPATOLOGY

Nuclear F-actin Formation and Reorganization upon Cell Spreading

(2015) Matthias Plessner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling

(2015) Costanza Giampietro et al.   JOURNAL OF CELL BIOLOGY

MRTF-A and YAP exert dual control in GPCR and RhoA-mediated transcriptional regulation and cell proliferation

(2015) Olivia Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

(2015) Francesca Zanconato et al.   NATURE CELL BIOLOGY

Cyclic stretching of soft substrates induces spreading and growth

(2015) Yidan Cui et al.   Nature Communications

Yes-associated protein regulates endothelial cell contact-mediated expression of angiopoietin-2

(2015) Hyun-Jung Choi et al.   Nature Communications

The Force at the Tip - Modelling Tension and Proliferation in Sprouting Angiogenesis

(2015) Patrícia Santos-Oliveira et al.   PLoS Computational Biology

Sensing the local environment: actin architecture and Hippo signalling

(2014) Pedro Gaspar et al.   CURRENT OPINION IN CELL BIOLOGY

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts

(2014) C. Esnault et al.   GENES & DEVELOPMENT

Tight coupling between nucleus and cell migration through the perinuclear actin cap

(2014) D.-H. Kim et al.   JOURNAL OF CELL SCIENCE

Angiomotins link F-actin architecture to Hippo pathway signaling

(2014) Sebastian Mana-Capelli et al.   MOLECULAR BIOLOGY OF THE CELL

MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2

(2014) Rabea Hinkel et al.   Nature Communications

Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation

(2014) Hiroyuki Nobusue et al.   Nature Communications

Super-resolution microscopy reveals LINC complex recruitment at nuclear indentation sites

(2014) Marie Versaevel et al.   Scientific Reports

Nuclear Mechanics and Mechanotransduction in Health and Disease

(2013) Philipp Isermann et al.   CURRENT BIOLOGY

SRF selectively controls tip cell invasive behavior in angiogenesis

(2013) C. A. Franco et al.   DEVELOPMENT

Morphological restriction of human coronary artery endothelial cells substantially impacts global gene expression patterns

(2013) Jessica M. Stiles et al.   FEBS Journal

The Hippo pathway: regulators and regulations

(2013) F.-X. Yu et al.   GENES & DEVELOPMENT

Cell Adhesion and Shape Regulate TGF-Beta1-Induced Epithelial-Myofibroblast Transition via MRTF-A Signaling

(2013) Joseph W. O’Connor et al.   PLoS One

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

(2012) B. Zhao et al.   GENES & DEVELOPMENT

Transcription factor regulation by mechanical stress

(2012) Melissa G. Mendez et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Mechanosensitive mechanisms in transcriptional regulation

(2012) Akiko Mammoto et al.   JOURNAL OF CELL SCIENCE

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Hippo Pathway-independent Restriction of TAZ and YAP by Angiomotin

(2011) Siew Wee Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

The nucleoskeleton as a genome-associated dynamic 'network of networks'

(2011) Dan N. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Hippo Signaling Pathway in Development and Cancer

(2010) Duojia Pan   DEVELOPMENTAL CELL

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Inducible gene targeting in the neonatal vasculature and analysis of retinal angiogenesis in mice

(2010) Mara E Pitulescu et al.   Nature Protocols

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(2009) M. D. Robinson et al.   BIOINFORMATICS

Vascular Mechanobiology

(2009) Joji Ando et al.   CIRCULATION JOURNAL

Serum Response Factor Is Required for Sprouting Angiogenesis and Vascular Integrity

(2008) Claudio Areias Franco et al.   DEVELOPMENTAL CELL

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

(2008) T. Dechat et al.   GENES & DEVELOPMENT

Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling

(2008) S. Busche et al.   JOURNAL OF CELL SCIENCE