Mechano-adaptation of the stem cell nucleus

Mechanosensing by the nucleus: From pathways to scaling relationships

(2017) Sangkyun Cho et al.   JOURNAL OF CELL BIOLOGY

Chromatin and lamin A determine two different mechanical response regimes of the cell nucleus

(2017) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells

(2016) Su-Jin Heo et al.   BIOPHYSICAL JOURNAL

Nesprin-2G, a Component of the Nuclear LINC Complex, Is Subject to Myosin-Dependent Tension

(2016) Paul T. Arsenovic et al.   BIOPHYSICAL JOURNAL

Aberrant Notch Signaling in the Bone Marrow Microenvironment of Acute Lymphoid Leukemia Suppresses Osteoblast-Mediated Support of Hematopoietic Niche Function

(2016) Weihuan Wang et al.   CANCER RESEARCH

Mechanotransduction and nuclear function

(2016) David M Graham et al.   CURRENT OPINION IN CELL BIOLOGY

Nanoscale architecture of cadherin-based cell adhesions

(2016) Cristina Bertocchi et al.   NATURE CELL BIOLOGY

Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment

(2016) Huy Quang Le et al.   NATURE CELL BIOLOGY

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

(2016) Chen Xi Li et al.   NATURE MATERIALS

Transcription upregulation via force-induced direct stretching of chromatin

(2016) Arash Tajik et al.   NATURE MATERIALS

Depletion of the LINC complex disrupts cytoskeleton dynamics and meiotic resumption in mouse oocytes

(2016) Yibo Luo et al.   Scientific Reports

Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity

(2016) Su-Jin Heo et al.   eLife

Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells

(2015) Tristan P. Driscoll et al.   BIOPHYSICAL JOURNAL

Differential basal-to-apical accessibility of lamin A/C epitopes in the nuclear lamina regulated by changes in cytoskeletal tension

(2015) Teemu O. Ihalainen et al.   NATURE MATERIALS

Three-dimensional genome architecture: players and mechanisms

(2015) Ana Pombo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The tethering of chromatin to the nuclear envelope supports nuclear mechanics

(2015) Sarah M. Schreiner et al.   Nature Communications

Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells

(2015) Su-Jin Heo et al.   Scientific Reports

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Interphase phosphorylation of lamin A

(2014) V. Kochin et al.   JOURNAL OF CELL SCIENCE

Nesprin-1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte-like cells in vivo and in vitro

(2014) WENGANG YANG et al.   Molecular Medicine Reports

FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement

(2014) Stefan Kutscheidt et al.   NATURE CELL BIOLOGY

Isolated nuclei adapt to force and reveal a mechanotransduction pathway in the nucleus

(2014) Christophe Guilluy et al.   NATURE CELL BIOLOGY

Mechanical memory and dosing influence stem cell fate

(2014) Chun Yang et al.   NATURE MATERIALS

Lamin A/C and emerin regulate MKL1–SRF activity by modulating actin dynamics

(2013) Chin Yee Ho et al.   NATURE

Biophysical regulation of epigenetic state and cell reprogramming

(2013) Timothy L. Downing et al.   NATURE MATERIALS

Lamina-associated polypeptide (LAP)2α and nucleoplasmic lamins in adult stem cell regulation and disease

(2013) Kevin Gesson et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mechanical Activation of Cells Induces Chromatin Remodeling Preceding MKL Nuclear Transport

(2012) K. Venkatesan Iyer et al.   BIOPHYSICAL JOURNAL

Chromatin Decondensation and Nuclear Softening Accompany Nanog Downregulation in Embryonic Stem Cells

(2012) Kevin J. Chalut et al.   BIOPHYSICAL JOURNAL

Samp1 is a component of TAN lines and is required for nuclear movement

(2012) J. Borrego-Pinto et al.   JOURNAL OF CELL SCIENCE

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Influences of lamin A levels on induction of pluripotent stem cells

(2012) B. Zuo et al.   Biology Open

Osmotic stress alters chromatin condensation and nucleocytoplasmic transport

(2011) John D. Finan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

The Interaction between Nesprins and Sun Proteins at the Nuclear Envelope Is Critical for Force Transmission between the Nucleus and Cytoskeleton

(2011) Maria L. Lombardi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanical compression drives cancer cells toward invasive phenotype

(2011) J. M. Tse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interactions Between Nuclei and the Cytoskeleton Are Mediated by SUN-KASH Nuclear-Envelope Bridges

(2010) Daniel A. Starr et al.   Annual Review of Cell and Developmental Biology

The epigenetic mechanism of mechanically induced osteogenic differentiation

(2010) Emily J. Arnsdorf et al.   JOURNAL OF BIOMECHANICS

Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

(2010) Carsten Grashoff et al.   NATURE

Nanoscale architecture of integrin-based cell adhesions

(2010) Pakorn Kanchanawong et al.   NATURE

α-Catenin as a tension transducer that induces adherens junction development

(2010) Shigenobu Yonemura et al.   NATURE CELL BIOLOGY

Lamin A variants that cause striated muscle disease are defective in anchoring transmembrane actin-associated nuclear lines for nuclear movement

(2010) E. S. Folker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linear Arrays of Nuclear Envelope Proteins Harness Retrograde Actin Flow for Nuclear Movement

(2010) G. W. G. Luxton et al.   SCIENCE

Mammalian SUN Protein Interaction Networks at the Inner Nuclear Membrane and Their Role in Laminopathy Disease Processes

(2009) Farhana Haque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stretching Single Talin Rod Molecules Activates Vinculin Binding

(2009) A. del Rio et al.   SCIENCE

Nuclear Shape, Mechanics, and Mechanotransduction

(2008) Kris Noel Dahl et al.   CIRCULATION RESEARCH

Nuclear mechanotransduction: Response of the lamina to extracellular stress with implications in aging

(2008) Julia T. Philip et al.   JOURNAL OF BIOMECHANICS

Loss of nucleoplasmic LAP2α–lamin A complexes causes erythroid and epidermal progenitor hyperproliferation

(2008) Nana Naetar et al.   NATURE CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY