Discovery of novel inhibitors for the treatment of glaucoma

Optimization of Dexamethasone Mixed Nanomicellar Formulation

(2014) Kishore Cholkar et al.   AAPS PHARMSCITECH

Nanomicellar Topical Aqueous Drop Formulation of Rapamycin for Back-of-the-Eye Delivery

(2014) Kishore Cholkar et al.   AAPS PHARMSCITECH

Discovery of Dual Leucine Zipper Kinase (DLK, MAP3K12) Inhibitors with Activity in Neurodegeneration Models

(2014) Snahel Patel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rapamycin Is Neuroprotective in a Rat Chronic Hypertensive Glaucoma Model

(2014) Wenru Su et al.   PLoS One

Dual Leucine Zipper Kinase Inhibitors: Potential Treatments for Neurodegenerative Diseases

(2014) Ahmed F. Abdel-Magid   ACS Medicinal Chemistry Letters

Ocular hypotensive efficacy of Src-family tyrosine kinase inhibitors via different cellular actions from Rock inhibitors

(2013) Tomoko Kirihara et al.   EXPERIMENTAL EYE RESEARCH

Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors

(2013) Yan Yin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Xanthates and Trithiocarbonates Strongly Inhibit Carbonic Anhydrases and Show Antiglaucoma Effects in Vivo

(2013) Fabrizio Carta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Rho-kinase inhibitors by docking-based virtual screening

(2013) Mingyun Shen et al.   Molecular BioSystems

Funktionelle Morphologie der Abflusswege des Kammerwassers und ihre Veränderungen beim Offenwinkelglaukom

(2013) E.R. Tamm   OPHTHALMOLOGE

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

(2013) D. S. Welsbie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation

(2013) L Liu et al.   Cell Death & Disease

Rho family GTPases

(2012) Alan Hall   BIOCHEMICAL SOCIETY TRANSACTIONS

Elevated Levels of RhoA in the Optic Nerve Head of Human Eyes With Glaucoma

(2012) Brian Goldhagen et al.   JOURNAL OF GLAUCOMA

Discovery and optimization of triazine derivatives as ROCK1 inhibitors: molecular docking, molecular dynamics simulations and free energy calculations

(2012) Mingyun Shen et al.   Molecular BioSystems

Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma

(2012) Kang Zhang et al.   NATURE REVIEWS DRUG DISCOVERY

Effects of roscovitine, a cell cycling-dependent kinase inhibitor, on intraocular pressure of rabbit and retinal ganglion cell damage

(2012) Hiroyoshi Kasai et al.   NEUROSCIENCE LETTERS

Myocilin Polymorphisms and Primary Open-Angle Glaucoma: A Systematic Review and Meta-Analysis

(2012) Jin-Wei Cheng et al.   PLoS One

Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)

(2012) Roberta Pireddu et al.   MedChemComm

Synthesis and biological evaluation of 4-quinazolinones as Rho kinase inhibitors

(2011) Xingang Fang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Interference of the Apoptotic Signaling Pathway in RGC Stress Response by SP600125 in Moderate Ocular Hypertensive Rats

(2011) Hong-Xia Liu   CHINESE JOURNAL OF PHYSIOLOGY

Effects of Rho-associated protein kinase inhibitors Y-27632 and Y-39983 on isolated rabbit ciliary arteries

(2011) Hiroshi Watabe et al.   JAPANESE JOURNAL OF OPHTHALMOLOGY

A new approach to antiglaucoma drugs: carbonic anhydrase inhibitors with or without NO donating moieties. Mechanism of action and preliminary pharmacology

(2011) Francesca Fabrizi et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Benzothiophene containing Rho kinase inhibitors: Efficacy in an animal model of glaucoma

(2010) Robert L. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors

(2010) Peter Ray et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors

(2010) Peter Ray et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oculohypotensive effect of perindopril in acute and chronic models of glaucoma in rabbits

(2010) Anita Mehta et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Synthesis, characterization and antiglaucoma activity of some novel pyrazole derivatives of 5-amino-1,3,4-thiadiazole-2-sulfonamide

(2010) Rahmi Kasımoğulları et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development and validation of a fast and sensitive bioanalytical method for the quantitative determination of glucocorticoids—Quantitative measurement of dexamethasone in rabbit ocular matrices by liquid chromatography tandem mass spectrometry

(2010) Ravinder Earla et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Discovery of Potent and Selective Urea-Based ROCK Inhibitors and Their Effects on Intraocular Pressure in Rats

(2010) Yan Yin et al.   ACS Medicinal Chemistry Letters

Nitric oxide-donating carbonic anhydrase inhibitors for the treatment of open-angle glaucoma

(2009) Rebecca M. Steele et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2,3-Diaminopyrazines as rho kinase inhibitors

(2009) Alan J. Henderson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Uveoscleral outflow – A review

(2009) Albert Alm et al.   EXPERIMENTAL EYE RESEARCH

Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors

(2009) Li-Li Gong et al.   JOURNAL OF BIOTECHNOLOGY

Novel Class of LIM-Kinase 2 Inhibitors for the Treatment of Ocular Hypertension and Associated Glaucoma

(2009) Bryce A. Harrison et al.   JOURNAL OF MEDICINAL CHEMISTRY

Benzimidazole- and benzoxazole-based inhibitors of Rho kinase

(2008) E. Hampton Sessions et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chroman-3-amides as potent Rho kinase inhibitors

(2008) Yen Ting Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of Flunarizine, a Calcium Channel Blocker, on Intraocular Pressure and Aqueous Humor Dynamics in Monkeys

(2008) Rong-Fang Wang et al.   JOURNAL OF GLAUCOMA

Discovery of Substituted 4-(Pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as Potent and Highly Selective Rho Kinase (ROCK-II) Inhibitors

(2008) Yangbo Feng et al.   JOURNAL OF MEDICINAL CHEMISTRY

H-1152 Effects on Intraocular Pressure and Trabecular Meshwork Morphology of Rat Eyes

(2008) Man Yu et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Direct Inhibition of N-Methyl-D-Aspartate (NMDA)-Receptor Function by Antiglaucomatous β-Antagonists

(2008) Tatsuo Nagata et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

(2008) Claudiu T. Supuran   NATURE REVIEWS DRUG DISCOVERY

Risk Factors for Glaucoma Onset and Progression

(2008) Anne L. Coleman et al.   SURVEY OF OPHTHALMOLOGY