Journal
ACS MEDICINAL CHEMISTRY LETTERS
Volume 8, Issue 12, Pages 1213-1217Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmedchemlett.7b00387
Keywords
Carbonic anhydrase; inhibitor; metalloenzymes; selenium; selenides; organoselenium compounds
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A series of novel selenides bearing benzene sulfonamide moieties was synthesized and investigated for the inhibition of five human (h) isoforms of zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1), hCA I, II, IV, VII, and IX. These enzymes are involved in a variety of diseases, including glaucoma, retinitis pigmentosa, epilepsy, arthritis, and tumors. The investigated compounds showed potent inhibitory action against hCA II, VII, and IX, in the low nanomolar range, thus making them of interest for the development of isoform-selective inhibitors and as candidates for biomedical applications.
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