Beyond the inflammasome: regulatory NOD-like receptor modulation of the host immune response following virus exposure

NLRX1 acts as tumor suppressor by regulating TNF-α induced apoptosis and metabolism in cancer cells

(2015) Kritarth Singh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Suppression of NLRX1 in chronic obstructive pulmonary disease

(2015) Min-Jong Kang et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRP6 Inflammasome Orchestrates the Colonic Host-Microbial Interface by Regulating Goblet Cell Mucus Secretion

(2014) Marta Wlodarska et al.   CELL

NOD-like receptors interfacing the immune and reproductive systems

(2014) Hanne Van Gorp et al.   FEBS Journal

NLRC3 Puts the Brakes on STING

(2014) Matthew S.J. Mangan et al.   IMMUNITY

Noncanonical NF-κB Pathway Controls the Production of Type I Interferons in Antiviral Innate Immunity

(2014) Jin Jin et al.   IMMUNITY

NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING

(2014) Lu Zhang et al.   IMMUNITY

The Mitochondrial Protein NLRX1 Controls the Balance between Extrinsic and Intrinsic Apoptosis

(2014) Fraser Soares et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nod2-Dependent Th2 Polarization of Antigen-Specific Immunity

(2014) J. G. Magalhaes et al.   JOURNAL OF IMMUNOLOGY

The multifaceted nature of NLRP12

(2014) Sinem Tuncer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Nucleotide Oligomerization and Binding Domain 2-Dependent Dendritic Cell Activation Is Necessary for Innate Immunity and Optimal CD8+ T Cell Responses to Influenza A Virus Infection

(2014) C. Lupfer et al.   JOURNAL OF VIROLOGY

Nod-Like Receptor X-1 Is Required for Rhinovirus-Induced Barrier Dysfunction in Airway Epithelial Cells

(2014) B. L. Unger et al.   JOURNAL OF VIROLOGY

Activation of Nucleotide Oligomerization Domain 2 (NOD2) by Human Cytomegalovirus Initiates Innate Immune Responses and Restricts Virus Replication

(2014) Arun Kapoor et al.   PLoS One

NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein

(2014) J. Jaworska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial exposure alters HIV-1-induced mucosal CD4+ T cell death pathways Ex vivo

(2014) Amanda K Steele et al.   Retrovirology

Porcine reproductive and respiratory syndrome virus infection activates NOD2–RIP2 signal pathway in MARC-145 cells

(2014) Huiyuan Jing et al.   VIROLOGY

The NLR protein, NLRX1, and its partner, TUFM, reduce type I interferon, and enhance autophagy

(2013) Yu Lei et al.   Autophagy

ERK signaling is triggered by hepatitis C virus E2 protein through DC-SIGN

(2013) Lan-Juan Zhao et al.   CELL STRESS & CHAPERONES

Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

(2013) M. H. Zaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of enteric pathogens by the nodosome

(2013) A. Marijke Keestra et al.   TRENDS IN IMMUNOLOGY

Unsolved Mysteries in NLR Biology

(2013) Christopher Lupfer et al.   Frontiers in Immunology

Respiratory syncytial virus infection augments NOD2 signaling in an IFN-β-dependent manner in human primary cells

(2012) Marloes Vissers et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Structure and Functional Characterization of the RNA-Binding Element of the NLRX1 Innate Immune Modulator

(2012) Minsun Hong et al.   IMMUNITY

NLRP12 Suppresses Colon Inflammation and Tumorigenesis through the Negative Regulation of Noncanonical NF-κB Signaling

(2012) Irving C. Allen et al.   IMMUNITY

The Mitochondrial Proteins NLRX1 and TUFM Form a Complex that Regulates Type I Interferon and Autophagy

(2012) Yu Lei et al.   IMMUNITY

NLRX1 does not inhibit MAVS-dependent antiviral signalling

(2012) Fraser Soares et al.   Innate Immunity

Pathogen Sensing by Nucleotide-binding Oligomerization Domain-containing Protein 2 (NOD2) Is Mediated by Direct Binding to Muramyl Dipeptide and ATP

(2012) Jinyao Mo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB

(2012) Monika Schneider et al.   NATURE IMMUNOLOGY

Characterization of NLRP12 during the Development of Allergic Airway Disease in Mice

(2012) Irving C. Allen et al.   PLoS One

The NOD-Like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis

(2011) Md. Hasan Zaki et al.   CANCER CELL

Viral Infection Augments Nod1/2 Signaling to Potentiate Lethality Associated with Secondary Bacterial Infections

(2011) Yun-Gi Kim et al.   Cell Host & Microbe

NLRX1 Negatively Regulates TLR-Induced NF-κB Signaling by Targeting TRAF6 and IKK

(2011) Xiaojun Xia et al.   IMMUNITY

NLRX1 Protein Attenuates Inflammatory Responses to Infection by Interfering with the RIG-I-MAVS and TRAF6-NF-κB Signaling Pathways

(2011) Irving C. Allen et al.   IMMUNITY

Expression, purification, and characterization of recombinant NOD1 (NLRC1): A NLR family member

(2011) Nadav Askari et al.   JOURNAL OF BIOTECHNOLOGY

Nucleotide-Binding Oligomerization Domain-Like Receptors and Inflammasomes in the Pathogenesis of Non-Microbial Inflammation and Diseases

(2011) D. Randal Mason et al.   Journal of Innate Immunity

Molecular and cellular correlates of the CIITA-mediated inhibition of HTLV-2 Tax-2 transactivator function resulting in loss of viral replication

(2011) Chiara Orlandi et al.   Journal of Translational Medicine

Major Histocompatibility Complex Class II Transactivator CIITA Is a Viral Restriction Factor That Targets Human T-Cell Lymphotropic Virus Type 1 Tax-1 Function and Inhibits Viral Replication

(2011) G. Tosi et al.   JOURNAL OF VIROLOGY

Non-apoptotic role of BID in inflammation and innate immunity

(2011) Garabet Yeretssian et al.   NATURE

STING is a direct innate immune sensor of cyclic di-GMP

(2011) Dara L. Burdette et al.   NATURE

Nod proteins link bacterial sensing and autophagy

(2010) Leonardo H. Travassos et al.   Autophagy

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Control of infection by pyroptosis and autophagy: role of TLR and NLR

(2010) Karina R. Bortoluci et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cytomegalovirus Infection in Patients with Active Inflammatory Bowel Disease

(2010) John J. Kim et al.   DIGESTIVE DISEASES AND SCIENCES

Pore Formation Triggered by Legionella spp. Is an Nlrc4 Inflammasome-Dependent Host Cell Response That Precedes Pyroptosis

(2010) T. N. Silveira et al.   INFECTION AND IMMUNITY

Enhancement of Reactive Oxygen Species Production and Chlamydial Infection by the Mitochondrial Nod-like Family Member NLRX1

(2010) Ali A. Abdul-Sater et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

(2010) Tomohiro Watanabe et al.   JOURNAL OF CLINICAL INVESTIGATION

NLRC5 Limits the Activation of Inflammatory Pathways

(2010) S. Benko et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NLRC5-Dependent Activation of the Inflammasome

(2010) B. K. Davis et al.   JOURNAL OF IMMUNOLOGY

Involvement of Absent in Melanoma 2 in Inflammasome Activation in Macrophages Infected with Listeria monocytogenes

(2010) K. Tsuchiya et al.   JOURNAL OF IMMUNOLOGY

Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria

(2010) Edward A Miao et al.   NATURE IMMUNOLOGY

NLR family member NLRC5 is a transcriptional regulator of MHC class I genes

(2010) T. B. Meissner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Respiratory Syncytial Virus Impairs Macrophage IFN-α/β– and IFN-γ–Stimulated Transcription by Distinct Mechanisms

(2009) Albert P. Senft et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Autophagy, antiviral immunity, and viral countermeasures

(2009) Sanae Shoji-Kawata et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix

(2009) D. Arnoult et al.   JOURNAL OF CELL SCIENCE

Nucleotide Oligomerization Binding Domain-Like Receptor Signaling Enhances Dendritic Cell-Mediated Cross-Priming In Vivo

(2009) J. Asano et al.   JOURNAL OF IMMUNOLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Activation of innate immune antiviral responses by Nod2

(2009) Ahmed Sabbah et al.   NATURE IMMUNOLOGY

Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

(2009) Leonardo H Travassos et al.   NATURE IMMUNOLOGY

Evaluation of Nod-Like Receptor (NLR) Effector Domain Interactions

(2009) Roland N. Wagner et al.   PLoS One

XIAP mediates NOD signaling via interaction with RIP2

(2009) A. Krieg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLR, the nucleotide-binding domain leucine-rich repeat containing gene family

(2008) Zhengmao Ye et al.   CURRENT OPINION IN IMMUNOLOGY

NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-κB and JNK pathways by inducing reactive oxygen species production

(2008) Ivan Tattoli et al.   EMBO REPORTS

Respiratory Syncytial Virus Induces RelA Release from Cytoplasmic 100-kDa NF-κB2 Complexes via a Novel Retinoic Acid-inducible Gene-I·NF-κB-inducing Kinase Signaling Pathway

(2008) Ping Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the ERK signal transduction pathway by Epstein-Barr virus immediate-early protein Rta

(2008) Y.-H. Lee et al.   JOURNAL OF GENERAL VIROLOGY

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Modulation of adaptive immunity by different adjuvant–antigen combinations in mice lacking Nod2

(2008) Lilian O. Moreira et al.   VACCINE

Toll-like Receptor 3 Activation Decreases Porcine Arterivirus Infection

(2008) Yongming Sang et al.   VIRAL IMMUNOLOGY