p53 mitotic centrosome localization preserves centrosome integrity and works as sensor for the mitotic surveillance pathway

Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis

(2018) Carla A.M. Lopes et al.   JOURNAL OF CELL BIOLOGY

A New Mode of Mitotic Surveillance

(2017) Bramwell G. Lambrus et al.   TRENDS IN CELL BIOLOGY

A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

(2016) Bramwell G. Lambrus et al.   JOURNAL OF CELL BIOLOGY

53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

(2016) Franz Meitinger et al.   JOURNAL OF CELL BIOLOGY

Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer

(2016) Andrea Prodosmo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis

(2016) Chii Shyang Fong et al.   eLife

p53 protects against genome instability following centriole duplication failure

(2015) Bramwell G. Lambrus et al.   JOURNAL OF CELL BIOLOGY

CRISPR-Cas9–based target validation for p53-reactivating model compounds

(2015) Michael Wanzel et al.   Nature Chemical Biology

Reversible centriole depletion with an inhibitor of Polo-like kinase 4

(2015) Y. L. Wong et al.   SCIENCE

p38- and MK2-dependent signalling promotes stress-induced centriolar satellite remodelling via 14-3-3-dependent sequestration of CEP131/AZI1

(2015) Maxim A. X. Tollenaere et al.   Nature Communications

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Cyclin B2 and p53 control proper timing of centrosome separation

(2014) Hyun-Ja Nam et al.   NATURE CELL BIOLOGY

Mitotic spindle multipolarity without centrosome amplification

(2014) Helder Maiato et al.   NATURE CELL BIOLOGY

p53 centrosomal localization diagnoses ataxia-telangiectasia homozygotes and heterozygotes

(2013) Andrea Prodosmo et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute Versus Chronic Loss of Mammalian Azi1/Cep131 Results in Distinct Ciliary Phenotypes

(2013) Emma A. Hall et al.   PLoS Genetics

The centriolar satellite protein Cep131 is important for genome stability

(2012) C. J. Staples et al.   JOURNAL OF CELL SCIENCE

p53: Guardian of ploidy

(2011) Yael Aylon et al.   Molecular Oncology

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Pericentrin in cellular function and disease

(2009) Benedicte Delaval et al.   JOURNAL OF CELL BIOLOGY

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

p53, cyclin-dependent kinase and abnormal amplification of centrosomes

(2008) Kenji Fukasawa   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Role for 53BP1 Tudor Domain Recognition of p53 Dimethylated at Lysine 382 in DNA Damage Signaling

(2008) Ioulia Kachirskaia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in the Pericentrin (PCNT) Gene Cause Primordial Dwarfism

(2008) A. Rauch et al.   SCIENCE

ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells

(2007) V. Stagni et al.   BLOOD