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Title
Do Mutations Turn p53 into an Oncogene?
Authors
Keywords
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Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 24, Pages 6241
Publisher
MDPI AG
Online
2019-12-12
DOI
10.3390/ijms20246241
References
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Note: Only part of the references are listed.- A gain-of-function p53 mutant oncogene promotes cell fate plasticity and myeloid leukemia through the pluripotency factor Foxh1
- (2019) Evangelia Loizou et al. Cancer Discovery
- The stiff RhoAd from mevalonate to mutant p53
- (2018) Giovanni Sorrentino et al. CELL DEATH AND DIFFERENTIATION
- Reviewing the future of the P53 field
- (2018) Arnold J Levine CELL DEATH AND DIFFERENTIATION
- Deciphering p53 signaling in tumor suppression
- (2018) Stephano S Mello et al. CURRENT OPINION IN CELL BIOLOGY
- Emerging Non-Canonical Functions and Regulation of p53
- (2018) Atul Ranjan et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- DNA repair processes are critical mediators of p53-dependent tumor suppression
- (2018) Ana Janic et al. NATURE MEDICINE
- Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion
- (2018) Ramona Schulz-Heddergott et al. CANCER CELL
- A mutant p53-dependent embryonic stem cell gene signature is associated with augmented tumorigenesis of stem cells
- (2018) Gabriela Koifman et al. CANCER RESEARCH
- p53 accumulation following cytokinesis failure in the absence of caspase-2
- (2018) Yoon Lim et al. CELL DEATH AND DIFFERENTIATION
- MDM2 controls gene expression independently of p53 in both normal and cancer cells
- (2018) Giuseppe Arena et al. CELL DEATH AND DIFFERENTIATION
- Reactivation of p53 gene by MDM2 inhibitors: A novel therapy for cancer treatment
- (2018) Amit Gupta et al. BIOMEDICINE & PHARMACOTHERAPY
- p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression
- (2018) Sung-Hwan Moon et al. CELL
- p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression
- (2018) Ivano Amelio et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The interplay between epigenetic changes and the p53 protein in stem cells
- (2017) Arnold J. Levine et al. GENES & DEVELOPMENT
- Mutant p53 in Cancer: Accumulation, Gain-of-Function, and Therapy
- (2017) Xuetian Yue et al. JOURNAL OF MOLECULAR BIOLOGY
- AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance
- (2017) Daniel Garcia et al. MOLECULAR CELL
- The most popular genes in the human genome
- (2017) NATURE
- Mechanical cues control mutant p53 stability through a mevalonate–RhoA axis
- (2017) Eleonora Ingallina et al. NATURE CELL BIOLOGY
- p53 loss-of-heterozygosity is a necessary prerequisite for mutant p53 stabilization and gain-of-function in vivo
- (2017) Evguenia M Alexandrova et al. Cell Death & Disease
- Depleting stabilized GOF mutant p53 proteins by inhibiting molecular folding chaperones: a new promise in cancer therapy
- (2016) Evguenia M Alexandrova et al. CELL DEATH AND DIFFERENTIATION
- p53 on the crossroad between regeneration and cancer
- (2016) Meital Charni et al. CELL DEATH AND DIFFERENTIATION
- Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family
- (2016) Sebastian Kehrloesser et al. CELL DEATH AND DIFFERENTIATION
- Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics
- (2016) Ruud H. Wijdeven et al. DRUG RESISTANCE UPDATES
- DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway
- (2016) Alejandro Parrales et al. NATURE CELL BIOLOGY
- The Cell-Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression
- (2016) Jiandong Chen Cold Spring Harbor Perspectives in Medicine
- Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53
- (2016) Neil T. Pfister et al. Cold Spring Harbor Perspectives in Medicine
- p53 in the DNA-Damage-Repair Process
- (2016) Ashley B. Williams et al. Cold Spring Harbor Perspectives in Medicine
- Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulateVEGFR2in breast cancer cells
- (2015) Neil T. Pfister et al. GENES & DEVELOPMENT
- Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment
- (2015) E. M. Alexandrova et al. NATURE
- Proteome-wide analysis of mutant p53 targets in breast cancer identifies new levels of gain-of-function that influence PARP, PCNA, and MCM4
- (2015) Alla Polotskaia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutant p53 gain of function can be at the root of dedifferentiation of human osteosarcoma MG63 cells into 3AB-OS cancer stem cells
- (2014) Riccardo Di Fiore et al. BONE
- Mutant p53 Drives Pancreatic Cancer Metastasis through Cell-Autonomous PDGF Receptor β Signaling
- (2014) Susann Weissmueller et al. CELL
- Regulation of Rad51 promoter
- (2014) Christopher M Hine et al. CELL CYCLE
- The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele
- (2014) Y Shetzer et al. CELL DEATH AND DIFFERENTIATION
- Gain-of-Function Mutant p53 Promotes Cell Growth and Cancer Cell Metabolism via Inhibition of AMPK Activation
- (2014) Ge Zhou et al. MOLECULAR CELL
- Heterogeneity of Li-Fraumeni Syndrome links to unequal gain-of-function effects of p53 mutations
- (2014) Jie Xu et al. Scientific Reports
- MUTYH, an adenine DNA glycosylase, mediates p53 tumor suppression via PARP-dependent cell death
- (2014) S Oka et al. Oncogenesis
- Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis
- (2013) W Hanel et al. CELL DEATH AND DIFFERENTIATION
- Evolution and dynamics of pancreatic cancer progression
- (2013) S Yachida et al. ONCOGENE
- Tumour-associated mutant p53 drives the Warburg effect
- (2013) Cen Zhang et al. Nature Communications
- Allele-Specific p53 Mutant Reactivation
- (2012) Xin Yu et al. CANCER CELL
- Mutant p53 Disrupts Mammary Tissue Architecture via the Mevalonate Pathway
- (2012) William A. Freed-Pastor et al. CELL
- Cancer stem cell hypothesis: a brief summary and two proposals
- (2012) Shuhua Zheng et al. CYTOTECHNOLOGY
- SAHA shows preferential cytotoxicity in mutant p53 cancer cells by destabilizing mutant p53 through inhibition of the HDAC6-Hsp90 chaperone axis
- (2011) D Li et al. CELL DEATH AND DIFFERENTIATION
- Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation
- (2011) Yongxing Wang et al. JOURNAL OF CLINICAL INVESTIGATION
- Functional Inactivation of Endogenous MDM2 and CHIP by HSP90 Causes Aberrant Stabilization of Mutant p53 in Human Cancer Cells
- (2011) D. Li et al. MOLECULAR CANCER RESEARCH
- Impact of cadmium on hOGG1 and APE1 as a function of the cellular p53 status
- (2011) Ingrit Hamann et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Concise Review: Mesenchymal Tumors: When Stem Cells Go Mad
- (2011) Alexander B. Mohseny et al. STEM CELLS
- Conditional RNA interference in vivo to study mutant p53 oncogenic gain of function on tumor malignancy
- (2010) Gianluca Bossi et al. CELL CYCLE
- p53 at a glance
- (2010) C. A. Brady et al. JOURNAL OF CELL SCIENCE
- Dysregulation of the mevalonate pathway promotes transformation
- (2010) J. W. Clendening et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- p53-based Cancer Therapy
- (2010) D. P. Lane et al. Cold Spring Harbor Perspectives in Biology
- Genetically transforming human mesenchymal stem cells to sarcomas
- (2009) Nan Li et al. CANCER
- PRIMA-1 Reactivates Mutant p53 by Covalent Binding to the Core Domain
- (2009) Jeremy M.R. Lambert et al. CANCER CELL
- Mutant p53 Drives Invasion by Promoting Integrin Recycling
- (2009) Patricia A.J. Muller et al. CELL
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- The execution of the transcriptional axis mutant p53, E2F1 and ID4 promotes tumor neo-angiogenesis
- (2009) Giulia Fontemaggi et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis
- (2009) J M R Lambert et al. ONCOGENE
- One billion years of p53/p63/p73 evolution
- (2009) V. A. Belyi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Origins and Evolution of the p53 Family of Genes
- (2009) V. A. Belyi et al. Cold Spring Harbor Perspectives in Biology
- TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use
- (2009) M. Olivier et al. Cold Spring Harbor Perspectives in Biology
- The genetics of the p53 pathway, apoptosis and cancer therapy
- (2008) Alexei Vazquez et al. NATURE REVIEWS DRUG DISCOVERY
- Transcriptional control of human p53-regulated genes
- (2008) Todd Riley et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
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