p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms

p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis

(2019) Le Li et al.   NATURE

ALOX12 is required for p53-mediated tumour suppression through a distinct ferroptosis pathway

(2019) Bo Chu et al.   NATURE CELL BIOLOGY

α-Ketoglutarate links p53 to cell fate during tumour suppression

(2019) John P. Morris et al.   NATURE

The Role and Function of microRNA in the Pathogenesis of Multiple Myeloma

(2019) Hiroshi Handa et al.   Cancers

Why do we need autophagy? A cartoon depiction

(2018) Daniel J. Klionsky   Autophagy

Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation

(2018) Thomas Goiran et al.   CELL DEATH AND DIFFERENTIATION

Deciphering p53 signaling in tumor suppression

(2018) Stephano S Mello et al.   CURRENT OPINION IN CELL BIOLOGY

GUARDIN is a p53-responsive long non-coding RNA that is essential for genomic stability

(2018) Wang Lai Hu et al.   NATURE CELL BIOLOGY

p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells

(2018) Amy Tarangelo et al.   Cell Reports

The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure

(2018) Eléonore Toufektchan et al.   Cancers

The Tip of an Iceberg: Replication-Associated Functions of the Tumor Suppressor p53

(2018) Vanesa Gottifredi et al.   Cancers

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

(2018) Sung-Hwan Moon et al.   CELL

p53 mutants cooperate with HIF-1 in transcriptional regulation of extracellular matrix components to promote tumor progression

(2018) Ivano Amelio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The interplay between epigenetic changes and the p53 protein in stem cells

(2017) Arnold J. Levine et al.   GENES & DEVELOPMENT

Neat1 is a p53-inducible lincRNA essential for transformation suppression

(2017) Stephano S. Mello et al.   GENES & DEVELOPMENT

Mechanical cues control mutant p53 stability through a mevalonate–RhoA axis

(2017) Eleonora Ingallina et al.   NATURE CELL BIOLOGY

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells

(2017) S Ros et al.   ONCOGENE

p21: A Two-Faced Genome Guardian

(2017) Alexandros G. Georgakilas et al.   TRENDS IN MOLECULAR MEDICINE

Metabolism in cancer metastasis: bioenergetics, biosynthesis, and beyond

(2017) Shao Thing Teoh et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

(2017) Yangchun Xie et al.   Cell Reports

P53 and the defenses against genome instability caused by transposons and repetitive elements

(2016) Arnold J. Levine et al.   BIOESSAYS

p53 in the game of transposons

(2016) Annika Wylie et al.   BIOESSAYS

p53 on the crossroad between regeneration and cancer

(2016) Meital Charni et al.   CELL DEATH AND DIFFERENTIATION

Activation ofSAT1engages polyamine metabolism with p53-mediated ferroptotic responses

(2016) Yang Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence

(2016) Crystal A. Tonnessen-Murray et al.   Cold Spring Harbor Perspectives in Medicine

p53 genes function to restrain mobile elements

(2015) Annika Wylie et al.   GENES & DEVELOPMENT

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

How to control self-digestion: transcriptional, post-transcriptional, and post-translational regulation of autophagy

(2015) Yuchen Feng et al.   TRENDS IN CELL BIOLOGY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

The evolution of thymic lymphomas in p53 knockout mice

(2014) Crissy Dudgeon et al.   GENES & DEVELOPMENT

Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit

(2014) Pavan Kumar Puvvula et al.   Nature Communications

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

p53 Acetylation: Regulation and Consequences

(2014) Sara Reed et al.   Cancers

p63 regulates glutaminase 2 expression

(2013) Giacobbe Arianna et al.   CELL CYCLE

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

Transcriptional cooperation between p53 and NF-κB p65 regulates microRNA-224 transcription in mouse ovarian granulosa cells

(2013) Meng Liang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Autophagy: A critical regulator of cellular metabolism and homeostasis

(2013) Stefan W. Ryter et al.   MOLECULES AND CELLS

p73 regulates serine biosynthesis in cancer

(2013) I Amelio et al.   ONCOGENE

Nuclear Localization of CD26 Induced by a Humanized Monoclonal Antibody Inhibits Tumor Cell Growth by Modulating of POLR2A Transcription

(2013) Kohji Yamada et al.   PLoS One

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

(2013) Liz J. Valente et al.   Cell Reports

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β

(2012) Stefan Termén et al.   JOURNAL OF CELLULAR PHYSIOLOGY

p53 Negatively Regulates Transcription of the Pyruvate Dehydrogenase Kinase Pdk2

(2011) T. Contractor et al.   CANCER RESEARCH

The dynamic nature of autophagy in cancer

(2011) A. C. Kimmelman   GENES & DEVELOPMENT

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition

(2011) Nam Hee Kim et al.   JOURNAL OF CELL BIOLOGY

p53 regulates epithelial–mesenchymal transition through microRNAs targeting ZEB1 and ZEB2

(2011) Taewan Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ROS-Mediated p53 Induction of Lpin1 Regulates Fatty Acid Oxidation in Response to Nutritional Stress

(2011) Wissam Assaily et al.   MOLECULAR CELL

p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs

(2011) Chun-Ju Chang et al.   NATURE CELL BIOLOGY

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

microRNA-192, -194 and -215 are frequently downregulated in colorectal cancer

(2011) YEUNPO CHIANG et al.   Experimental and Therapeutic Medicine

p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma

(2010) Seung-Oe Lim et al.   FEBS LETTERS

MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro

(2010) Manuela Quintavalle et al.   JOURNAL OF CELL BIOLOGY

ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy

(2010) Kathryn G Eby et al.   Molecular Cancer

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

(2010) W. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis

(2010) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis

(2009) Hong-li Yan et al.   EMBO JOURNAL

p53 Suppresses Src-Induced Podosome and Rosette Formation and Cellular Invasiveness through the Upregulation of Caldesmon

(2009) U. K. Mukhopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

p53 represses c-Myc through induction of the tumor suppressor miR-145

(2009) M. Sachdeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY