How Does p73 Cause Neuronal Defects?

MicroRNAs in Plasma and Cerebrospinal Fluid as Potential Markers for Alzheimer's Disease

(2018) Takehiro Kiko et al.   JOURNAL OF ALZHEIMERS DISEASE

The case for rejecting the amyloid cascade hypothesis

(2015) Karl Herrup   NATURE NEUROSCIENCE

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

(2015) Erik S Musiek et al.   NATURE NEUROSCIENCE

p63 and p73 coordinate p53 function to determine the balance between survival, cell death and senescence in adult neural precursor cells

(2014) M P Fatt et al.   CELL DEATH AND DIFFERENTIATION

Wnt–Notch signalling crosstalk in development and disease

(2014) Giovanna M. Collu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

How theTP53Family ProteinsTP63andTP73Contribute to Tumorigenesis: Regulators and Effectors

(2014) Eleonora Candi et al.   HUMAN MUTATION

Amyloid Beta: Multiple Mechanisms of Toxicity and Only Some Protective Effects?

(2014) Paul Carrillo-Mora et al.   Oxidative Medicine and Cellular Longevity

TAp73 is required for spermatogenesis and the maintenance of male fertility

(2014) Satoshi Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dipeptide analysis of p53 mutations and evolution of p53 family proteins

(2013) Qiang Huang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

GLS2 is transcriptionally regulated by p73 and contributes to neuronal differentiation

(2013) Tania Velletri et al.   CELL CYCLE

p53 regulates a non-apoptotic death induced by ROS

(2013) J Montero et al.   CELL DEATH AND DIFFERENTIATION

ΔNp63 regulates select routes of reprogramming via multiple mechanisms

(2013) E M Alexandrova et al.   CELL DEATH AND DIFFERENTIATION

Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis

(2013) Y-C Chen et al.   CELL DEATH AND DIFFERENTIATION

p73 – constitutively open for business

(2013) M A Seeliger et al.   CELL DEATH AND DIFFERENTIATION

p53 talks to PARP: the increasing complexity of p53-induced cell death

(2013) K G Wiman   CELL DEATH AND DIFFERENTIATION

Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis

(2013) N S Chari et al.   CELL DEATH AND DIFFERENTIATION

Analysis of the oligomeric state and transactivation potential of TAp73α

(2013) L M Luh et al.   CELL DEATH AND DIFFERENTIATION

p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene

(2013) Z He et al.   CELL DEATH AND DIFFERENTIATION

Not all p53 gain-of-function mutants are created equal

(2013) S S Mello et al.   CELL DEATH AND DIFFERENTIATION

p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity

(2013) A Molchadsky et al.   CELL DEATH AND DIFFERENTIATION

Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis

(2013) W Hanel et al.   CELL DEATH AND DIFFERENTIATION

ProNGF\NGF imbalance triggers learning and memory deficits, neurodegeneration and spontaneous epileptic-like discharges in transgenic mice

(2013) C Tiveron et al.   CELL DEATH AND DIFFERENTIATION

Jaw growth in the absence of teeth: the developmental morphology of edentulous mandibles using the p63 mouse mutant

(2013) Mitchell R. Paradis et al.   EVOLUTION & DEVELOPMENT

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

Multiple Roles of the p75 Neurotrophin Receptor in the Nervous System

(2013) Y Chen et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Alternative polyadenylation and miR-34 family members regulate tau expression

(2013) John R. Dickson et al.   JOURNAL OF NEUROCHEMISTRY

Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts

(2013) Badri Vardarajan et al.   Molecular Neurodegeneration

TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor

(2013) M. V. Niklison-Chirou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory feedback loop between TP73 and TRIM32

(2013) L Gonzalez-Cano et al.   Cell Death & Disease

TRIM32-dependent transcription in adult neural progenitor cells regulates neuronal differentiation

(2013) A-L Hillje et al.   Cell Death & Disease

Suppression of the p75 receptor signal attenuates the effect of ephrin-B3 and promotes axonal regeneration of the injured optic nerve

(2013) N Uesugi et al.   Cell Death & Disease

Imbalance of p75NTR/TrkB protein expression in Huntington’s disease: implication for neuroprotective therapies

(2013) V Brito et al.   Cell Death & Disease

Mutant p53-R273H gains new function in sustained activation of EGFR signaling via suppressing miR-27a expression

(2013) W Wang et al.   Cell Death & Disease

Mature neurons: equipped for survival

(2013) A J Kole et al.   Cell Death & Disease

Amyloid-β and Alzheimer’s disease type pathology differentially affects the calcium signalling toolkit in astrocytes from different brain regions

(2013) A A Grolla et al.   Cell Death & Disease

Cooperative role of RanBP9 and P73 in mitochondria-mediated apoptosis

(2013) T Liu et al.   Cell Death & Disease

PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context

(2013) T Valentino et al.   Cell Death & Disease

A p38mapk-p53 cascade regulates mesodermal differentiation and neurogenesis of embryonic stem cells

(2013) Y Hadjal et al.   Cell Death & Disease

RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer’s brain synaptosomes

(2013) J P Palavicini et al.   Cell Death & Disease

USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

(2013) Y-H Fan et al.   Cell Death & Disease

A DR6/p75NTR complex is responsible for β-amyloid-induced cortical neuron death

(2013) Y Hu et al.   Cell Death & Disease

Tissue-specific expression of p73 C-terminal isoforms in mice

(2012) Francesca Grespi et al.   CELL CYCLE

p73 is dispensable for commitment to neural stem cell fate, but is essential for neural stem cell maintenance and for blocking premature differentiation

(2012) E M Alexandrova et al.   CELL DEATH AND DIFFERENTIATION

TAp73 is required for macrophage-mediated innate immunity and the resolution of inflammatory responses

(2012) R Tomasini et al.   CELL DEATH AND DIFFERENTIATION

MicroRNAs tune cerebral cortical neurogenesis

(2012) M-L Volvert et al.   CELL DEATH AND DIFFERENTIATION

Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome

(2012) Giustina Ferone et al.   EMBO Molecular Medicine

The p53 family grows old

(2012) E. R. Flores et al.   GENES & DEVELOPMENT

p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome

(2012) Giustina Ferone et al.   HUMAN MOLECULAR GENETICS

p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease

(2012) Gonzalo I. Cancino et al.   NEUROBIOLOGY OF AGING

Functional interplay between p63 and p53 controls RUNX1 function in the transition from proliferation to differentiation in human keratinocytes

(2012) I Masse et al.   Cell Death & Disease

p63 in tooth development

(2011) Alessandro Rufini et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of skin aging and heart development by TAp63

(2011) M Paris et al.   CELL DEATH AND DIFFERENTIATION

Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity

(2011) V Marcel et al.   CELL DEATH AND DIFFERENTIATION

p63, a Story of Mice and Men

(2011) Hans Vanbokhoven et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

p73: A Multifunctional Protein in Neurobiology

(2011) Richard Killick et al.   MOLECULAR NEUROBIOLOGY

The p53 family: guardians of maternal reproduction

(2011) Arnold J. Levine et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Transcriptional Regulation of Neuronal Polarity and Morphogenesis in the Mammalian Brain

(2011) Luis de la Torre-Ubieta et al.   NEURON

miR-34a Regulates Mouse Neural Stem Cell Differentiation

(2011) Márcia M. Aranha et al.   PLoS One

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA-34a regulates neurite outgrowth, spinal morphology, and function

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TAp63 Is Important for Cardiac Differentiation of Embryonic Stem Cells and Heart Development

(2011) Matthieu Rouleau et al.   STEM CELLS

p73 regulates maintenance of neural stem cell

(2010) Massimiliano Agostini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis

(2010) F Talos et al.   CELL DEATH AND DIFFERENTIATION

TAp73 Acts via the bHLH Hey2 to Promote Long-Term Maintenance of Neural Precursors

(2010) Masashi Fujitani et al.   CURRENT BIOLOGY

miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells

(2010) Carolina Tarantino et al.   FASEB JOURNAL

Isoform-specific p73 knockout mice reveal a novel role for  Np73 in the DNA damage response pathway

(2010) M. T. Wilhelm et al.   GENES & DEVELOPMENT

Molecular mechanisms of neurodegeneration in Alzheimer's disease

(2010) L. Crews et al.   HUMAN MOLECULAR GENETICS

Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons

(2010) Michael Fricker et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

(2010) Lars M. Ittner et al.   NATURE REVIEWS NEUROSCIENCE

p53 Is Regulated by and Regulates Members of the γ-Secretase Complex

(2010) Frédéric Checler et al.   Neurodegenerative Diseases

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

(2010) Bart De Strooper   PHYSIOLOGICAL REVIEWS

p63 and p73, the Ancestors of p53

(2010) V. Dotsch et al.   Cold Spring Harbor Perspectives in Biology

p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53

(2010) L Gonzalez-Cano et al.   Cell Death & Disease

Cancer and Neurodegeneration: Between the Devil and the Deep Blue Sea

(2010) Hélène Plun-Favreau et al.   PLoS Genetics

MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiation

(2009) S. T. Hashimi et al.   BLOOD

miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation

(2009) Xiaoying Wang et al.   BRAIN RESEARCH BULLETIN

The TRIM-NHL Protein TRIM32 Activates MicroRNAs and Prevents Self-Renewal in Mouse Neural Progenitors

(2009) Jens C. Schwamborn et al.   CELL

p63 Antagonizes p53 to Promote the Survival of Embryonic Neural Precursor Cells

(2009) C. B. Dugani et al.   JOURNAL OF NEUROSCIENCE

Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh

(2009) Rebecca Favaro et al.   NATURE NEUROSCIENCE

DeltaNp73 regulates neuronal survival in vivo

(2009) F. Tissir et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased locomotor activity in mice lacking the low-density lipoprotein receptor

(2008) Gregory A. Elder et al.   BEHAVIOURAL BRAIN RESEARCH

The tumour suppressor p53 regulates the expression of amyloid precursor protein (APP)

(2008) Ascensión Cuesta et al.   BIOCHEMICAL JOURNAL

DNp73 a matter of cancer: Mechanisms and clinical implications

(2008) Sven Buhlmann et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

A Hierarchical Network Controls Protein Translation during Murine Embryonic Stem Cell Self-Renewal and Differentiation

(2008) Prabha Sampath et al.   Cell Stem Cell

p63 in epithelial development

(2008) E. Candi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

(2008) R. Tomasini et al.   GENES & DEVELOPMENT

Adult neural stem cells and their role in brain pathology

(2008) G Yadirgi et al.   JOURNAL OF PATHOLOGY

p73 Regulates Neurodegeneration and Phospho-Tau Accumulation during Aging and Alzheimer's Disease

(2008) Monica K. Wetzel et al.   NEURON

Genomic Anatomy of the Hippocampus

(2008) Carol L. Thompson et al.   NEURON

The MYCN oncogene is a direct target of miR-34a

(2008) J S Wei et al.   ONCOGENE