How theTP53Family ProteinsTP63andTP73Contribute to Tumorigenesis: Regulators and Effectors

Phospho-ΔNp63α/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure

(2013) Yiping Huang et al.   CELL CYCLE

p63 regulates glutaminase 2 expression

(2013) Giacobbe Arianna et al.   CELL CYCLE

Analysis of the oligomeric state and transactivation potential of TAp73α

(2013) L M Luh et al.   CELL DEATH AND DIFFERENTIATION

p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene

(2013) Z He et al.   CELL DEATH AND DIFFERENTIATION

Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses

(2013) D. Kenzelmann Broz et al.   GENES & DEVELOPMENT

IκB Kinase β (IKKβ) Inhibits p63 Isoform γ (TAp63γ) Transcriptional Activity

(2013) Jun-Ming Liao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis

(2013) Rubeta N. Matin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TAp73 enhances the pentose phosphate pathway and supports cell proliferation

(2013) Wenjing Du et al.   NATURE CELL BIOLOGY

p73 regulates serine biosynthesis in cancer

(2013) I Amelio et al.   ONCOGENE

TAp73 knockout mice show morphological and functional nervous system defects associated with loss of p75 neurotrophin receptor

(2013) M. V. Niklison-Chirou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia

(2013) J.-C. Pignon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory feedback loop between TP73 and TRIM32

(2013) L Gonzalez-Cano et al.   Cell Death & Disease

E2F1 confers anticancer drug resistance by targeting ABC transporter family members and Bcl-2 via the p73/DNp73-miR-205 circuitry

(2012) Vijay Alla et al.   CELL CYCLE

miR-205 regulates basement membrane deposition in human prostate: implications for cancer development

(2012) P Gandellini et al.   CELL DEATH AND DIFFERENTIATION

TAp63 Is a Master Transcriptional Regulator of Lipid and Glucose Metabolism

(2012) Xiaohua Su et al.   Cell Metabolism

 Np63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation

(2012) R.-A. Romano et al.   DEVELOPMENT

Cell density-dependent acetylation of ΔNp63α is associated with p53-dependent cell cycle arrest

(2012) Yang-Seok Chae et al.   FEBS LETTERS

TAp73 depletion accelerates aging through metabolic dysregulation

(2012) A. Rufini et al.   GENES & DEVELOPMENT

The p63 Protein Isoform ΔNp63α Inhibits Epithelial-Mesenchymal Transition in Human Bladder Cancer Cells

(2012) Mai N. Tran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

(2012) Oliver D. K. Maddocks et al.   NATURE

Structure of p73 DNA-binding domain tetramer modulates p73 transactivation

(2012) A. S. Ethayathulla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p63-microRNA feedback in keratinocyte senescence

(2012) P. Rivetti di Val Cervo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer

(2012) P. Tucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of the promyelocytic leukaemia protein in cell death regulation

(2012) P Salomoni et al.   Cell Death & Disease

Functional interplay between p63 and p53 controls RUNX1 function in the transition from proliferation to differentiation in human keratinocytes

(2012) I Masse et al.   Cell Death & Disease

Cancer metabolism: current perspectives and future directions

(2012) C Muñoz-Pinedo et al.   Cell Death & Disease

Consumption of oxygen: a mitochondrial-generated progression signal of advanced cancer

(2012) C C Cook et al.   Cell Death & Disease

MicroRNA-203 contributes to skin re-epithelialization

(2012) G Viticchiè et al.   Cell Death & Disease

Regulation of p73 activity by post-translational modifications

(2012) F Conforti et al.   Cell Death & Disease

DNA Damage in Oocytes Induces a Switch of the Quality Control Factor TAp63α from Dimer to Tetramer

(2011) Gregor B. Deutsch et al.   CELL

Immunofluorescence-based screening identifies germ cell associated microRNA 302 as an antagonist to p63 expression

(2011) Andreas Scheel et al.   CELL CYCLE

Regulation of ΔNp63α by NFκΒ 

(2011) Tanusree Sen et al.   CELL CYCLE

Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level

(2011) V Graupner et al.   CELL DEATH AND DIFFERENTIATION

Regulation of skin aging and heart development by TAp63

(2011) M Paris et al.   CELL DEATH AND DIFFERENTIATION

Diverse p63 and p73 isoforms regulate Δ133p53 expression through modulation of the internal TP53 promoter activity

(2011) V Marcel et al.   CELL DEATH AND DIFFERENTIATION

Cell death by autophagy: facts and apparent artefacts

(2011) D Denton et al.   CELL DEATH AND DIFFERENTIATION

p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53

(2011) G Melino   CELL DEATH AND DIFFERENTIATION

Many stimuli pull the necrotic trigger, an overview

(2011) N Vanlangenakker et al.   CELL DEATH AND DIFFERENTIATION

iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia

(2011) Anissa Chikh et al.   EMBO JOURNAL

Oxidative stress activation of miR-125b is part of the molecular switch for Hailey-Hailey disease manifestation

(2011) Sonia Manca et al.   EXPERIMENTAL DERMATOLOGY

Tumor Protein p63/Nuclear Factor κB Feedback Loop in Regulation of Cell Death

(2011) Tanusree Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A microRNA-dependent program controls p53-independent survival and chemosensitivity in human and murine squamous cell carcinoma

(2011) Benjamin Ory et al.   JOURNAL OF CLINICAL INVESTIGATION

p63, a Story of Mice and Men

(2011) Hans Vanbokhoven et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

p73: A Multifunctional Protein in Neurobiology

(2011) Richard Killick et al.   MOLECULAR NEUROBIOLOGY

An integrative genomic approach identifies p73 and p63 as activators of miR-200 microRNA family transcription

(2011) Emily C. Knouf et al.   NUCLEIC ACIDS RESEARCH

HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage

(2011) C Lazzari et al.   ONCOGENE

P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism

(2011) S Al-Bahlani et al.   ONCOGENE

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

microRNA-34a regulates neurite outgrowth, spinal morphology, and function

(2011) M. Agostini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p73 regulates maintenance of neural stem cell

(2010) Massimiliano Agostini et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The E3 ubiquitin ligase WWP1 regulates ΔNp63-dependent transcription through Lys63 linkages

(2010) Angelo Peschiaroli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interaction of regulators Mdm2 and Mdmx with transcription factors p53, p63 and p73

(2010) Michal Zdzalik et al.   CELL CYCLE

p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis

(2010) F Talos et al.   CELL DEATH AND DIFFERENTIATION

Isoform-specific p73 knockout mice reveal a novel role for  Np73 in the DNA damage response pathway

(2010) M. T. Wilhelm et al.   GENES & DEVELOPMENT

MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation

(2010) F. Galli et al.   JOURNAL OF CELL SCIENCE

Transcriptional Repression of miR-34 Family Contributes to p63-Mediated Cell Cycle Progression in Epidermal Cells

(2010) Dario Antonini et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs

(2010) Xiaohua Su et al.   NATURE

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Differential control of TAp73 and  Np73 protein stability by the ring finger ubiquitin ligase PIR2

(2010) B. S. Sayan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway

(2010) I. Dulloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p63 and p73, the Ancestors of p53

(2010) V. Dotsch et al.   Cold Spring Harbor Perspectives in Biology

c-Abl phosphorylation of ΔNp63α is critical for cell viability

(2010) M Yuan et al.   Cell Death & Disease

p73, miR106b, miR34a, and Itch in chronic lymphocytic leukemia

(2009) P. R. di Val Cervo et al.   BLOOD

A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

(2009) Maddalena Adorno et al.   CELL

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

The microRNA miR-92 increases proliferation of myeloid cells and by targeting p63 modulates the abundance of its isoforms

(2009) Isabella Manni et al.   FASEB JOURNAL

Stxbp4 Regulates  Np63 Stability by Suppression of RACK1-Dependent Degradation

(2009) Y. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

HIPK2 modulates p53 activity towards pro-apoptotic transcription

(2009) Rosa Puca et al.   Molecular Cancer

Enhanced Fas-associated death domain recruitment by histone deacetylase inhibitors is critical for the sensitization of chronic lymphocytic leukemia cells to TRAIL-induced apoptosis

(2009) S. Inoue et al.   MOLECULAR CANCER THERAPEUTICS

TAp63 induces senescence and suppresses tumorigenesis in vivo

(2009) Xuecui Guo et al.   NATURE CELL BIOLOGY

Inhibition of the c-Abl–TAp63 pathway protects mouse oocytes from chemotherapy-induced death

(2009) Stefania Gonfloni et al.   NATURE MEDICINE

Identification and functional characterization of two new transcriptional variants of the human p63 gene

(2009) Marina Mangiulli et al.   NUCLEIC ACIDS RESEARCH

The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73

(2009) A Peschiaroli et al.   ONCOGENE

Caspase cleavage of Itch in chronic lymphocytic leukemia cells

(2008) Mario Rossi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation

(2008) D. Sampath et al.   BLOOD

MicroRNA-21 Targets a Network of Key Tumor-Suppressive Pathways in Glioblastoma Cells

(2008) T. Papagiannakopoulos et al.   CANCER RESEARCH

WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis

(2008) Y Li et al.   CELL DEATH AND DIFFERENTIATION

miR-203 represses ‘stemness’ by repressing ΔNp63

(2008) A M Lena et al.   CELL DEATH AND DIFFERENTIATION

Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

(2008) G Melino et al.   CELL DEATH AND DIFFERENTIATION

Control of autophagy by oncogenes and tumor suppressor genes

(2008) M C Maiuri et al.   CELL DEATH AND DIFFERENTIATION

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

(2008) R. Tomasini et al.   GENES & DEVELOPMENT

A Regulatory Circuit Controlling Itch-mediated p73 Degradation by Runx

(2008) Dan Levy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Gene Signature-Based Approach Identifies mTOR as a Regulator of p73

(2008) J. M. Rosenbluth et al.   MOLECULAR AND CELLULAR BIOLOGY

Yap1 Phosphorylation by c-Abl Is a Critical Step in Selective Activation of Proapoptotic Genes in Response to DNA Damage

(2008) Dan Levy et al.   MOLECULAR CELL

PML, YAP, and p73 Are Components of a Proapoptotic Autoregulatory Feedback Loop

(2008) Eleonora Lapi et al.   MOLECULAR CELL

The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1

(2008) Philip A. Gregory et al.   NATURE CELL BIOLOGY

miRNAs, ‘stemness’ and skin

(2008) D ABERDAM et al.   TRENDS IN BIOCHEMICAL SCIENCES

Noncanonical DNA Motifs as Transactivation Targets by Wild Type and Mutant p53

(2008) Jennifer J. Jordan et al.   PLoS Genetics