Epigenetic mechanisms in neurogenesis

Embryonic Origin of Postnatal Neural Stem Cells

(2015) Luis C. Fuentealba et al.   CELL

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

Adult Mammalian Neural Stem Cells and Neurogenesis: Five Decades Later

(2015) Allison M. Bond et al.   Cell Stem Cell

Ankrd11 Is a Chromatin Regulator Involved in Autism that Is Essential for Neural Development

(2015) Denis Gallagher et al.   DEVELOPMENTAL CELL

Epigenetic regulation of presenilin 1 and 2 in the cerebral cortex of mice during development

(2015) Ashish Kumar et al.   Developmental Neurobiology

RNAN6-methyladenosine methylation in post-transcriptional gene expression regulation

(2015) Yanan Yue et al.   GENES & DEVELOPMENT

Rett syndrome: disruption of epigenetic control of postnatal neurological functions

(2015) Amy E. Pohodich et al.   HUMAN MOLECULAR GENETICS

A Specific LSD1/KDM1A Isoform Regulates Neuronal Differentiation through H3K9 Demethylation

(2015) Benoit Laurent et al.   MOLECULAR CELL

Disruption of DNA-methylation-dependent long gene repression in Rett syndrome

(2015) Harrison W. Gabel et al.   NATURE

Dynamic m6A mRNA methylation directs translational control of heat shock response

(2015) Jun Zhou et al.   NATURE

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

5-Formylcytosine can be a stable DNA modification in mammals

(2015) Martin Bachman et al.   Nature Chemical Biology

Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation

(2015) Gerald J Sun et al.   NATURE NEUROSCIENCE

Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex

(2015) Andrew E Jaffe et al.   NATURE NEUROSCIENCE

Methylation QTLs in the developing brain and their enrichment in schizophrenia risk loci

(2015) Eilis Hannon et al.   NATURE NEUROSCIENCE

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

(2015) Shohei Furutachi et al.   NATURE NEUROSCIENCE

Epigenomic Signatures of Neuronal Diversity in the Mammalian Brain

(2015) Alisa Mo et al.   NEURON

MeCP2 binds to non-CG methylated DNA as neurons mature, influencing transcription and the timing of onset for Rett syndrome

(2015) Lin Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

Noncanonical Sites of Adult Neurogenesis in the Mammalian Brain

(2015) David M. Feliciano et al.   Cold Spring Harbor Perspectives in Biology

Adult Neurogenesis in Neurodegenerative Diseases: Figure 1.

(2015) Beate Winner et al.   Cold Spring Harbor Perspectives in Biology

Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory

(2015) Jacqueline A. Bonds et al.   PLoS One

Functions and Dysfunctions of Adult Hippocampal Neurogenesis

(2014) Kimberly M. Christian et al.   Annual Review of Neuroscience

Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions

(2014) Hao Wu et al.   CELL

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

(2014) Xiao-Li Ping et al.   CELL RESEARCH

Long Noncoding RNAs in Cell-Fate Programming and Reprogramming

(2014) Ryan A. Flynn et al.   Cell Stem Cell

m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells

(2014) Pedro J. Batista et al.   Cell Stem Cell

LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

(2014) Dayne A. Beccano-Kelly et al.   HUMAN MOLECULAR GENETICS

N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells

(2014) Yang Wang et al.   NATURE CELL BIOLOGY

Decoding neural transcriptomes and epigenomes via high-throughput sequencing

(2014) Jaehoon Shin et al.   NATURE NEUROSCIENCE

Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

(2014) Philip L De Jager et al.   NATURE NEUROSCIENCE

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

(2014) Kate D. Meyer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adult Neurogenesis and Mental Illness

(2014) Timothy J Schoenfeld et al.   NEUROPSYCHOPHARMACOLOGY

Distinct roles of the methylcytosine oxidases Tet1 and Tet2 in mouse embryonic stem cells

(2014) Y. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurogenesis in the embryonic and adult brain: same regulators, different roles

(2014) Noelia Urbán et al.   Frontiers in Cellular Neuroscience

A Brief History of Epigenetics

(2014) G. Felsenfeld   Cold Spring Harbor Perspectives in Biology

Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway

(2014) Hongda Li et al.   Nature Communications

Methylome-Wide Association Study of Schizophrenia

(2014) Karolina A. Aberg et al.   JAMA Psychiatry

Long non-coding RNA-dependent transcriptional regulation in neuronal development and disease

(2014) Brian S. Clark et al.   Frontiers in Genetics

Genome-wide Profiling of 5-Formylcytosine Reveals Its Roles in Epigenetic Priming

(2013) Chun-Xiao Song et al.   CELL

Dynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives

(2013) Cornelia G. Spruijt et al.   CELL

Integration of Genome-wide Approaches Identifies lncRNAs of Adult Neural Stem Cells and Their Progeny In Vivo

(2013) Alexander D. Ramos et al.   Cell Stem Cell

Tet1 Regulates Adult Hippocampal Neurogenesis and Cognition

(2013) Run-Rui Zhang et al.   Cell Stem Cell

Epigenetic signature and enhancer activity of the human APOE gene

(2013) Chang-En Yu et al.   HUMAN MOLECULAR GENETICS

Genome-wide loss of 5-hmC is a novel epigenetic feature of Huntington's disease

(2013) Fengli Wang et al.   HUMAN MOLECULAR GENETICS

DNA methylation of the BDNF gene and its relevance to psychiatric disorders

(2013) Tempei Ikegame et al.   JOURNAL OF HUMAN GENETICS

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

Distribution, recognition and regulation of non-CpG methylation in the adult mammalian brain

(2013) Junjie U Guo et al.   NATURE NEUROSCIENCE

Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer's disease patients

(2013) Leonidas Chouliaras et al.   NEUROBIOLOGY OF AGING

BDNF deregulation in Rett syndrome

(2013) Wei Li et al.   NEUROPHARMACOLOGY

What's wrong with epigenetics in Huntington's disease?

(2013) Luis M. Valor et al.   NEUROPHARMACOLOGY

Extensive changes in DNA methylation are associated with expression of mutant huntingtin

(2013) C. W. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA-methylation gene network dysregulation in peripheral blood lymphocytes of schizophrenia patients

(2013) J. Auta et al.   SCHIZOPHRENIA RESEARCH

Global Epigenomic Reconfiguration During Mammalian Brain Development

(2013) R. Lister et al.   SCIENCE

MicroRNA Cluster miR-17-92 Regulates Neural Stem Cell Expansion and Transition to Intermediate Progenitors in the Developing Mouse Neocortex

(2013) Shan Bian et al.   Cell Reports

Dynamics of 5-Hydroxymethylcytosine and Chromatin Marks in Mammalian Neurogenesis

(2013) Maria A. Hahn et al.   Cell Reports

DNA methylation presents distinct binding sites for human transcription factors

(2013) Shaohui Hu et al.   eLife

Chromatin-based epigenetics of adult subventricular zone neural stem cells

(2013) Gabriel Gonzales-Roybal et al.   Frontiers in Genetics

Signaling mechanisms regulating adult neural stem cells and neurogenesis

(2012) Roland Faigle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

MeCP2 Binds to 5hmC Enriched within Active Genes and Accessible Chromatin in the Nervous System

(2012) Marian Mellén et al.   CELL

Base-Resolution Analysis of 5-Hydroxymethylcytosine in the Mammalian Genome

(2012) Miao Yu et al.   CELL

Tet3 CXXC Domain and Dioxygenase Activity Cooperatively Regulate Key Genes for Xenopus Eye and Neural Development

(2012) Yufei Xu et al.   CELL

Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis

(2012) Tamara Ratovitski et al.   CELL CYCLE

Role of DNMT3B in the regulation of early neural and neural crest specifiers

(2012) Kristen Martins-Taylor et al.   Epigenetics

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein

(2012) Hyun Jin Cho et al.   HUMAN MOLECULAR GENETICS

Mechanistic insights into the regulation of metabolic enzymes by acetylation

(2012) Yue Xiong et al.   JOURNAL OF CELL BIOLOGY

Role of  -Synuclein in Adult Neurogenesis and Neuronal Maturation in the Dentate Gyrus

(2012) B. Winner et al.   JOURNAL OF NEUROSCIENCE

Pten Deletion in Adult Hippocampal Neural Stem/Progenitor Cells Causes Cellular Abnormalities and Alters Neurogenesis

(2012) A. Amiri et al.   JOURNAL OF NEUROSCIENCE

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

microRNA-9 regulates axon extension and branching by targeting Map1b in mouse cortical neurons

(2012) Federico Dajas-Bailador et al.   NATURE NEUROSCIENCE

Histone methylation: a dynamic mark in health, disease and inheritance

(2012) Eric L. Greer et al.   NATURE REVIEWS GENETICS

Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain

(2012) Dyna I. Shirasaki et al.   NEURON

Reversible RNA adenosine methylation in biological regulation

(2012) Guifang Jia et al.   TRENDS IN GENETICS

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

Epigenetics in Alzheimers Disease: a Focus on DNA Modifications

(2011) Natacha Coppieters et al.   CURRENT PHARMACEUTICAL DESIGN

α-Synuclein Sequesters Dnmt1 from the Nucleus

(2011) Paula Desplats et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways

(2011) Garwin Pichler et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Neuronal activity modifies the DNA methylation landscape in the adult brain

(2011) Junjie U Guo et al.   NATURE NEUROSCIENCE

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

(2011) Keith E Szulwach et al.   NATURE NEUROSCIENCE

Trithorax group proteins: switching genes on and keeping them active

(2011) Bernd Schuettengruber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions

(2011) Guo-li Ming et al.   NEURON

The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?

(2011) David Petrik et al.   NEUROPHARMACOLOGY

Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA

(2011) Y.-F. He et al.   SCIENCE

Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine

(2011) S. Ito et al.   SCIENCE

miR-137 forms a regulatory loop with nuclear receptor TLX and LSD1 in neural stem cells

(2011) GuoQiang Sun et al.   Nature Communications

Impaired adult olfactory bulb neurogenesis in the R6/2 mouse model of Huntington's disease

(2010) Zacharias Kohl et al.   BMC NEUROSCIENCE

Epigenetic Regulation of miR-184 by MBD1 Governs Neural Stem Cell Proliferation and Differentiation

(2010) Changmei Liu et al.   Cell Stem Cell

Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains

(2010) A. Jowaed et al.   JOURNAL OF NEUROSCIENCE

Histone Demethylase LSD1 Regulates Neural Stem Cell Proliferation

(2010) G. Sun et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

(2010) Shinsuke Ito et al.   NATURE

Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways

(2010) Antonella Riccio   NATURE NEUROSCIENCE

Epigenetic choreographers of neurogenesis in the adult mammalian brain

(2010) Dengke K Ma et al.   NATURE NEUROSCIENCE

Epigenetic control of neural precursor cell fate during development

(2010) Yusuke Hirabayashi et al.   NATURE REVIEWS NEUROSCIENCE

Roles of small regulatory RNAs in determining neuronal identity

(2010) Xuekun Li et al.   NATURE REVIEWS NEUROSCIENCE

Epigenetics, hippocampal neurogenesis, and neuropsychiatric disorders: Unraveling the genome to understand the mind

(2010) Jenny Hsieh et al.   NEUROBIOLOGY OF DISEASE

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

(2010) H.L. Melrose et al.   NEUROBIOLOGY OF DISEASE

Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice

(2010) B. Winner et al.   NEUROBIOLOGY OF DISEASE

Hippocampal neurogenesis as a target for the treatment of mental illness: A critical evaluation

(2010) Nathan A. DeCarolis et al.   NEUROPHARMACOLOGY

CpG Demethylation Enhances Alpha-Synuclein Expression and Affects the Pathogenesis of Parkinson's Disease

(2010) Lumine Matsumoto et al.   PLoS One

MicroRNA let-7b regulates neural stem cell proliferation and differentiation by targeting nuclear receptor TLX signaling

(2010) C. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex

(2010) J. D. Pereira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dnmt3a-Dependent Nonpromoter DNA Methylation Facilitates Transcription of Neurogenic Genes

(2010) H. Wu et al.   SCIENCE

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice

(2009) Gang Li et al.   Cell Stem Cell

Histone deacetylase inhibitors and candidate gene expression: An in vivo and in vitro approach to studying chromatin remodeling in a clinical population

(2009) David P. Gavin et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis

(2009) D Taliaz et al.   MOLECULAR PSYCHIATRY

Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells

(2009) Daniel A. Lim et al.   NATURE

Balanced gene regulation by an embryonic brain ncRNA is critical for adult hippocampal GABA circuitry

(2009) Allison M Bond et al.   NATURE NEUROSCIENCE

Collagen VI protects neurons against Aβ toxicity

(2009) Jason S Cheng et al.   NATURE NEUROSCIENCE

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

(2009) Quan Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Bdnf overexpression in hippocampal neurons prevents dendritic atrophy caused by Rett-associated MECP2 mutations

(2009) Jennifer L. Larimore et al.   NEUROBIOLOGY OF DISEASE

Polycomb Limits the Neurogenic Competence of Neural Precursor Cells to Promote Astrogenic Fate Transition

(2009) Yusuke Hirabayashi et al.   NEURON

Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

(2009) D. K. Ma et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

(2008) Kunal Rai et al.   CELL

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Histone deacetylases 1 and 2 are expressed at distinct stages of neuro-glial development

(2008) Jessica L. MacDonald et al.   DEVELOPMENTAL DYNAMICS

Epigenetic Regulation of the Stem Cell Mitogen Fgf-2 by Mbd1 in Adult Neural Stem/Progenitor Cells

(2008) Xuekun Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurodegeneration and Motor Dysfunction in a Conditional Model of Parkinson's Disease

(2008) S. Nuber et al.   JOURNAL OF NEUROSCIENCE

Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors

(2008) Fabio Mohn et al.   MOLECULAR CELL

Histone Deacetylases Control Neurogenesis in Embryonic Brain by Inhibition of BMP2/4 Signaling

(2008) Maya Shakèd et al.   PLoS One

Specification of CNS glia from neural stem cells in the embryonic neuroepithelium

(2007) N. Kessaris et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES