The pyrin inflammasome and the Yersinia effector interaction

The pyrin inflammasome in host–microbe interactions

(2020) Nicole A Loeven et al.   CURRENT OPINION IN MICROBIOLOGY

Ancient familial Mediterranean fever mutations in human pyrin and resistance to Yersinia pestis

(2020) Yong Hwan Park et al.   NATURE IMMUNOLOGY

Characterization of pyrin dephosphorylation and inflammasome activation in macrophages as triggered by the Yersinia effectors YopE and YopT

(2019) Natasha P. Medici et al.   INFECTION AND IMMUNITY

Bile acid analogues are activators of Pyrin inflammasome

(2019) Irina Alimov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Restriction of HIV-1 and other retroviruses by TRIM5

(2019) Barbie K. Ganser-Pornillos et al.   NATURE REVIEWS MICROBIOLOGY

The Pyrin Inflammasome in Health and Disease

(2019) Oskar Schnappauf et al.   Frontiers in Immunology

Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients

(2019) Flora Magnotti et al.   EMBO Molecular Medicine

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis

(2018) Deepika Sharma et al.   GASTROENTEROLOGY

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

(2018) Apurva Kanneganti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The species-spanning family of LPX-motif harbouring effector proteins

(2018) Stefanie Norkowski et al.   CELLULAR MICROBIOLOGY

All Yersinia Are Not Created Equal: Phenotypic Adaptation to Distinct Niches Within Mammalian Tissues

(2018) Kimberly M. Davis   Frontiers in Cellular and Infection Microbiology

TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy

(2018) Deepika Sharma et al.   JOURNAL OF CLINICAL INVESTIGATION

Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection

(2018) Joseph Sarhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

RIPK1-dependent apoptosis bypasses pathogen blockade of innate signaling to promote immune defense

(2017) Lance W. Peterson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Familial Mediterranean fever mutations are hypermorphic mutations that specifically decrease the activation threshold of the Pyrin inflammasome

(2017) Yvan Jamilloux et al.   RHEUMATOLOGY

Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death

(2017) Jianjin Shi et al.   TRENDS IN BIOCHEMICAL SCIENCES

A Burkholderia Type VI Effector Deamidates Rho GTPases to Activate the Pyrin Inflammasome and Trigger Inflammation

(2016) Daniel F. Aubert et al.   Cell Host & Microbe

The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome

(2016) Lawton K. Chung et al.   Cell Host & Microbe

Yersinia versus host immunity: how a pathogen evades or triggers a protective response

(2016) Lawton K Chung et al.   CURRENT OPINION IN MICROBIOLOGY

Uncovering an Important Role for YopJ in the Inhibition of Caspase-1 in Activated Macrophages and Promoting Yersinia pseudotuberculosis Virulence

(2016) Taylor J. Schoberle et al.   INFECTION AND IMMUNITY

Manipulation of Interleukin-1β and Interleukin-18 Production byYersinia pestisEffectors YopJ and YopM and Redundant Impact on Virulence

(2016) Dmitry Ratner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell-Extrinsic TNF Collaborates with TRIF Signaling To PromoteYersinia-Induced Apoptosis

(2016) Lance W. Peterson et al.   JOURNAL OF IMMUNOLOGY

YopJ Family Effectors Promote Bacterial Infection through a Unique Acetyltransferase Activity

(2016) Ka-Wai Ma et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS

(2016) Yong Hwan Park et al.   NATURE IMMUNOLOGY

'Add, stir and reduce': Yersinia spp. as model bacteria for pathogen evolution

(2016) Alan McNally et al.   NATURE REVIEWS MICROBIOLOGY

Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation

(2016) Wenqing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

(2016) Hanne Van Gorp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular innate immune surveillance devices in plants and animals

(2016) J. D. G. Jones et al.   SCIENCE

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

(2016) Seth L. Masters et al.   Science Translational Medicine

The Yersinia Type III secretion effector YopM Is an E3 ubiquitin ligase that induced necrotic cell death by targeting NLRP3

(2016) Congwen Wei et al.   Cell Death & Disease

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation

(2016) Dmitry Ratner et al.   PLoS Pathogens

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

(2015) Tomonori Kimura et al.   JOURNAL OF CELL BIOLOGY

Crystal structure of TRIM20 C-terminal coiled-coil/B30.2 fragment: implications for the recognition of higher order oligomers

(2015) Christopher Weinert et al.   Scientific Reports

Identification of Multifaceted Binding Modes for Pyrin and ASC Pyrin Domains Gives Insights into Pyrin Inflammasome Assembly

(2014) Parimala R. Vajjhala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF- B and MAPK signaling

(2014) N. H. Philip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death

(2014) D. Weng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological roles of Rho and Rho effectors in mammals

(2013) Dean Thumkeo et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Inflammation in Mice Ectopically Expressing Human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T Mutant Proteins

(2013) Donghai Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Yersinia Virulence Effector YopM Binds Caspase-1 to Arrest Inflammasome Assembly and Processing

(2012) Christopher N. LaRock et al.   Cell Host & Microbe

Cell death programs in Yersinia immunity and pathogenesis

(2012) Naomi H. Philip et al.   Frontiers in Cellular and Infection Microbiology

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

(2011) Jae Jin Chae et al.   IMMUNITY

ROS-inhibitory activity of YopE is required for full virulence of Yersinia in mice

(2010) Warangkhana Songsungthong et al.   CELLULAR MICROBIOLOGY

Delineation of Regions of the Yersinia YopM Protein Required for Interaction with the RSK1 and PRK2 Host Kinases and Their Requirement for Interleukin-10 Production and Virulence

(2010) J. B. McPhee et al.   INFECTION AND IMMUNITY

The C-Terminal Tail of Yersinia pseudotuberculosis YopM Is Critical for Interacting with RSK1 and for Virulence

(2010) M. W. McCoy et al.   INFECTION AND IMMUNITY

Yersinia Virulence Factor YopM Induces Sustained RSK Activation by Interfering with Dephosphorylation

(2010) Moritz Hentschke et al.   PLoS One

Yersinia pseudotuberculosis Virulence Determinants Invasin, YopE, and YopT Modulate RhoG Activity and Localization

(2009) S. Mohammadi et al.   INFECTION AND IMMUNITY

The Crystal Structure of Human Pyrin B30.2 Domain: Implications for Mutations Associated with Familial Mediterranean Fever

(2009) Christopher Weinert et al.   JOURNAL OF MOLECULAR BIOLOGY

Yersinia Controls Type III Effector Delivery into Host Cells by Modulating Rho Activity

(2008) Edison Mejía et al.   PLoS Pathogens

Regulation of Yersinia Yop-effector delivery by translocated YopE

(2007) Margareta Aili et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY