Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation

Control of the innate immune response by the mevalonate pathway

(2016) Murali K Akula et al.   NATURE IMMUNOLOGY

Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS

(2016) Yong Hwan Park et al.   NATURE IMMUNOLOGY

Site-specific phosphorylation and microtubule dynamics control Pyrin inflammasome activation

(2016) Wenqing Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

(2016) Seth L. Masters et al.   Science Translational Medicine

Clostridium difficile infection

(2016) Wiep Klaas Smits et al.   Nature Reviews Disease Primers

Evidence-based recommendations for genetic diagnosis of familial Mediterranean fever

(2015) Gabriella Giancane et al.   ANNALS OF THE RHEUMATIC DISEASES

Colchicine, Biologic Agents and More for the Treatment of Familial Mediterranean Fever. The Old, the New, and the Rare

(2015) P. Portincasa   CURRENT MEDICINAL CHEMISTRY

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

NOD-like receptors interfacing the immune and reproductive systems

(2014) Hanne Van Gorp et al.   FEBS Journal

Tumor Progression Locus 2 (Tpl2) Kinase Promotes Chemokine Receptor Expression and Macrophage Migration during Acute Inflammation

(2014) Sean M. Rowley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation

(2014) Mary A. Rodgers et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

(2014) Lieselotte Vande Walle et al.   NATURE

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation

(2014) Nina Van Opdenbosch et al.   Nature Communications

A clinical guide to autoinflammatory diseases: familial Mediterranean fever and next-of-kin

(2013) Seza Ozen et al.   Nature Reviews Rheumatology

Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review

(2012) Nienke ter Haar et al.   ANNALS OF THE RHEUMATIC DISEASES

An International registry on Autoinflammatory diseases: the Eurofever experience

(2012) Natasa Toplak et al.   ANNALS OF THE RHEUMATIC DISEASES

Activation of the Pyrin Inflammasome by Intracellular Burkholderia cenocepacia

(2012) M. A. Gavrilin et al.   JOURNAL OF IMMUNOLOGY

Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages

(2012) X. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nucleotide-Binding Oligomerization Domain 1 Mediates Recognition of Clostridium difficile and Induces Neutrophil Recruitment and Protection against the Pathogen

(2011) M. Hasegawa et al.   JOURNAL OF IMMUNOLOGY

Modulation of Inflammasome Pathways by Bacterial and Viral Pathogens

(2011) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes

(2010) Jianghong Wu et al.   JOURNAL OF CLINICAL IMMUNOLOGY

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

(2009) Seth L. Masters et al.   Annual Review of Immunology

Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression

(2009) Bradley A Carlson et al.   BMC IMMUNOLOGY

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

(2009) Mohamed Lamkanfi et al.   JOURNAL OF CELL BIOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

Function of C/EBPδ in a regulatory circuit that discriminates between transient and persistent TLR4-induced signals

(2009) Vladimir Litvak et al.   NATURE IMMUNOLOGY

Clostridium difficile Toxin CDT Induces Formation of Microtubule-Based Protrusions and Increases Adherence of Bacteria

(2009) Carsten Schwan et al.   PLoS Pathogens

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

The infevers autoinflammatory mutation online registry: update with new genes and functions

(2008) Florian Milhavet et al.   HUMAN MUTATION