TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis

(2018) Deepika Sharma et al.   GASTROENTEROLOGY

GSDMD is critical for autoinflammatory pathology in a mouse model of Familial Mediterranean Fever

(2018) Apurva Kanneganti et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tyrosine Kinase SYK Licenses MyD88 Adaptor Protein to Instigate IL-1α-Mediated Inflammatory Disease

(2017) Prajwal Gurung et al.   IMMUNITY

Inflammatory cell death in intestinal pathologies

(2017) Deepika Sharma et al.   IMMUNOLOGICAL REVIEWS

Inflammasome activation and assembly at a glance

(2017) Ankit Malik et al.   JOURNAL OF CELL SCIENCE

TNF regulates transcription of NLRP3 inflammasome components and inflammatory molecules in cryopyrinopathies

(2017) Matthew D. McGeough et al.   JOURNAL OF CLINICAL INVESTIGATION

Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow

(2017) Emily Bowers et al.   NATURE MEDICINE

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

(2016) Martin Chopra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transmembrane TNF-α Reverse Signaling Inhibits Lipopolysaccharide-Induced Proinflammatory Cytokine Formation in Macrophages by Inducing TGF-β: Therapeutic Implications

(2016) Anna Pallai et al.   JOURNAL OF IMMUNOLOGY

Distinct role of IL-1β in instigating disease in Sharpincpdm mice

(2016) Prajwal Gurung et al.   Scientific Reports

The Inflammatory Caspases-1 and -11 Mediate the Pathogenesis of Dermatitis in Sharpin-Deficient Mice

(2015) Todd Douglas et al.   JOURNAL OF IMMUNOLOGY

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

Inflammasome Activation Contributes to Interleukin-23 Production in Response to Clostridium difficile

(2015) Carrie A. Cowardin et al.   mBio

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Anti-TNF agents in familial Mediterranean fever: report of three cases and review of the literature

(2014) Salih Ozgocmen et al.   Modern Rheumatology

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

Monogenic autoinflammatory diseases: Concept and clinical manifestations

(2013) Adriana Almeida de Jesus et al.   CLINICAL IMMUNOLOGY

Patient management and the association of less common familial Mediterranean fever symptoms with other disorders

(2013) Mike M. Moradian et al.   GENETICS IN MEDICINE

TNFR2 Is Critical for the Stabilization of the CD4+Foxp3+ Regulatory T Cell Phenotype in the Inflammatory Environment

(2013) X. Chen et al.   JOURNAL OF IMMUNOLOGY

Effects of Anti-Tumor Necrosis Factor Agents for Familial Mediterranean Fever Patients With Chronic Arthritis and/or Sacroiliitis Who Were Resistant to Colchicine Treatment

(2012) Sule Apras Bilgen et al.   JCR-JOURNAL OF CLINICAL RHEUMATOLOGY

Activation of the Pyrin Inflammasome by Intracellular Burkholderia cenocepacia

(2012) M. A. Gavrilin et al.   JOURNAL OF IMMUNOLOGY

Gain-of-Function Pyrin Mutations Induce NLRP3 Protein-Independent Interleukin-1β Activation and Severe Autoinflammation in Mice

(2011) Jae Jin Chae et al.   IMMUNITY

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

Successful treatment with anti-tumor necrosis factor (anti-TNF)-alpha of proteinuria in a patient with familial mediterranean fever (FMF) resistant to colchicine: anti-TNF drugs and FMF

(2011) S. Erten et al.   RHEUMATOLOGY INTERNATIONAL

Advances in the understanding of familial Mediterranean fever and possibilities for targeted therapy

(2009) Jae J. Chae et al.   BRITISH JOURNAL OF HAEMATOLOGY

Time-course analysis of serum hepcidin, iron and cytokines in a C282Y homozygous patient with Schnitzler's syndrome treated with IL-1 receptor antagonist

(2009) M. van Deuren et al.   HAEMATOLOGICA

Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-α by macrophages

(2009) Xingmin Sun et al.   MICROBIAL PATHOGENESIS

Tumor necrosis factor-alpha (TNF-α) induces integrin CD11b/CD18 (Mac-1) up-regulation and migration to the CC chemokine CCL3 (MIP-1α) on human neutrophils through defined signalling pathways

(2007) Fabrizio Montecucco et al.   CELLULAR SIGNALLING