Selective inhibition of NLRP3 inflammasome by designed peptide originating from ASC

Innate Immune Signaling Organelles Display Natural and Programmable Signaling Flexibility

(2019) Yunhao Tan et al.   CELL

Inflammasomes in neuroinflammatory and neurodegenerative diseases

(2019) Sofie Voet et al.   EMBO Molecular Medicine

MCC950 directly targets the NLRP3 ATP-hydrolysis motif for inflammasome inhibition

(2019) Rebecca C. Coll et al.   Nature Chemical Biology

MCC950 closes the active conformation of NLRP3 to an inactive state

(2019) Ana Tapia-Abellán et al.   Nature Chemical Biology

Structure, interactions and self-assembly of ASC-dependent inflammasomes

(2019) Eva de Alba   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

(2019) Humayun Sharif et al.   NATURE

Inflammasomes: Threat-Assessment Organelles of the Innate Immune System

(2019) Charles L. Evavold et al.   IMMUNITY

MCC950/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition

(2019) Lieselotte Vande Walle et al.   PLOS BIOLOGY

Inflammasome-mediated innate immunity in Alzheimer’s disease

(2019) Carmen Venegas et al.   FASEB JOURNAL

Ion homeostasis and ion channels in NLRP3 inflammasome activation and regulation

(2018) Iva Hafner-Bratkovič et al.   CURRENT OPINION IN IMMUNOLOGY

Tranilast directly targets NLRP3 to treat inflammasome‐driven diseases

(2018) Yi Huang et al.   EMBO Molecular Medicine

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

New workflow for classification of genetic variants' pathogenicity applied to hereditary recurrent fevers by the International Study Group for Systemic Autoinflammatory Diseases (INSAID)

(2018) Marielle E Van Gijn et al.   JOURNAL OF MEDICAL GENETICS

Single-Molecule Fluorescence Reveals the Oligomerization and Folding Steps Driving the Prion-like Behavior of ASC

(2018) Yann Gambin et al.   JOURNAL OF MOLECULAR BIOLOGY

OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation

(2018) Carlo Marchetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

(2018) Hongbin He et al.   Nature Communications

Targeting the NLRP3 inflammasome in inflammatory diseases

(2018) Matthew S. J. Mangan et al.   NATURE REVIEWS DRUG DISCOVERY

Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1

(2018) Yang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway

(2018) Iva Hafner-Bratkovič et al.   Nature Communications

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

(2017) Hua Jiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease

(2017) Mattia Cocco et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

The PYRIN domain-only protein POP2 inhibits inflammasome priming and activation

(2017) Rojo A. Ratsimandresy et al.   Nature Communications

Pyrin-only protein 2 limits inflammation but improves protection against bacteria

(2017) Sivakumar Periasamy et al.   Nature Communications

The role of the C-terminal D0 domain of flagellin in activation of Toll like receptor 5

(2017) Vida Forstnerič et al.   PLoS Pathogens

ASC Pyrin Domain Self-associates and Binds NLRP3 Protein Using Equivalent Binding Interfaces

(2016) Javier Oroz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

(2016) Florian I. Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 recruitment by NLRC4 duringSalmonellainfection

(2016) Yan Qu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

(2016) Alvin Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ASC filament formation serves as a signal amplification mechanism for inflammasomes

(2016) Mathias S. Dick et al.   Nature Communications

Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism

(2016) Alvin Lu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1

(2016) Jernej Zorman et al.   PLoS One

Inhibition of protein aggregation and amyloid formation by small molecules

(2015) Andrew J Doig et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The PYRIN Domain-only Protein POP1 Inhibits Inflammasome Assembly and Ameliorates Inflammatory Disease

(2015) Lucia de Almeida et al.   IMMUNITY

Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy

(2015) Ya-Ping Chang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy

(2015) Lorenzo Sborgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization

(2015) L. Zhang et al.   SCIENCE

Structural and biochemical basis for induced self-propagation of NLRC4

(2015) Z. Hu et al.   SCIENCE

Biochemical and structural aspects of the ATP-binding domain in inflammasome-forming human NLRP proteins

(2015) Justin A. MacDonald et al.   IUBMB LIFE

An updated view on the structure and function of PYRIN domains

(2014) Lan Hoang Chu et al.   APOPTOSIS

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

(2014) Loren D. Walensky et al.   JOURNAL OF MEDICINAL CHEMISTRY

The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

(2014) Sonal Khare et al.   NATURE IMMUNOLOGY

The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response

(2014) Alberto Baroja-Mazo et al.   NATURE IMMUNOLOGY

Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

(2014) S. M. Man et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging

(2013) Yun-Hee Youm et al.   Cell Metabolism

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

(2013) Raúl Muñoz-Planillo et al.   IMMUNITY

Dimethyl sulfoxide inhibits NLRP3 inflammasome activation

(2013) Huijeong Ahn et al.   IMMUNOBIOLOGY

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

(2013) Dominic De Nardo et al.   NATURE IMMUNOLOGY

Treating inflammation by blocking interleukin-1 in humans

(2013) Charles A. Dinarello et al.   SEMINARS IN IMMUNOLOGY

The CARD plays a critical role in ASC foci formation and inflammasome signalling

(2012) Martina Proell et al.   BIOCHEMICAL JOURNAL

NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity

(2012) Iva Hafner-Bratkovič et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes

(2012) Hye-Mi Lee et al.   DIABETES

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Recent evolution of the NF-κB and inflammasome regulating protein POP2 in primates

(2011) Maninjay K Atianand et al.   BMC EVOLUTIONARY BIOLOGY

Crystal Structure of NALP3 Protein Pyrin Domain (PYD) and Its Implications in Inflammasome Assembly

(2011) Ju Young Bae et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Intermediary Domain of MyD88 in Cell Activation and Therapeutic Inhibition of TLRs

(2011) M. Avbelj et al.   JOURNAL OF IMMUNOLOGY

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome

(2010) Christine Juliana et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Viral Inhibitory Peptide of TLR4, a Peptide Derived from Vaccinia Protein A46, Specifically Inhibits TLR4 by Directly Targeting MyD88 Adaptor-Like and TRIF-Related Adaptor Molecule

(2010) T. Lysakova-Devine et al.   JOURNAL OF IMMUNOLOGY

The serum and cerebrospinal fluid pharmacokinetics of anakinra after intravenous administration to non-human primates

(2010) Elizabeth Fox et al.   JOURNAL OF NEUROIMMUNOLOGY

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Structure and Interdomain Dynamics of Apoptosis-associated Speck-like Protein Containing a CARD (ASC)

(2009) Eva de Alba   JOURNAL OF BIOLOGICAL CHEMISTRY

Mapping of POP1-binding Site on Pyrin Domain of ASC

(2008) Thiagarajan Srimathi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY