Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Shikonin Suppresses NLRP3 and AIM2 Inflammasomes by Direct Inhibition of Caspase-1
Authors
Keywords
Inflammasomes, Transcription factors, Macrophages, Enzyme-linked immunoassays, Particulates, Cell cultures, Immune receptor signaling, Toxicity
Journal
PLoS One
Volume 11, Issue 7, Pages e0159826
Publisher
Public Library of Science (PLoS)
Online
2016-07-29
DOI
10.1371/journal.pone.0159826
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Neuroinflammation in Alzheimer's disease
- (2015) Michael T Heneka et al. LANCET NEUROLOGY
- Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK
- (2015) Ying Li et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Shikonin inhibits the lipopolysaccharide-induced release of HMGB1 in RAW264.7 cells via IFN and NF-κB signaling pathways
- (2014) Ying Yang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Shikonin Inhibits the Proliferation of Human Lens Epithelial Cells by Inducing Apoptosis through ROS and Caspase-Dependent Pathway
- (2014) Wan-Rong Huang et al. MOLECULES
- An Oxidative Stress Mechanism of Shikonin in Human Glioma Cells
- (2014) Jen-Tsung Yang et al. PLoS One
- Antimalarial Drug Artemisinin Extenuates Amyloidogenesis and Neuroinflammation in APPswe/PS1dE9 Transgenic Mice via Inhibition of Nuclear Factor-κB and NLRP3 Inflammasome Activation
- (2013) Jian-Quan Shi et al. CNS Neuroscience & Therapeutics
- Traditional Chinese Medicine Remedy to Jury: The Pharmacological Basis for the Use of Shikonin as an Anticancer Therapy
- (2013) I. Andujar et al. CURRENT MEDICINAL CHEMISTRY
- K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
- (2013) Raúl Muñoz-Planillo et al. IMMUNITY
- Succinate is an inflammatory signal that induces IL-1β through HIF-1α
- (2013) G. M. Tannahill et al. NATURE
- Pharmacological Properties of Shikonin – A Review of Literature since 2002
- (2013) Isabel Andújar et al. PLANTA MEDICA
- NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity
- (2012) Iva Hafner-Bratkovič et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Lithospermum erythrorhizon Suppresses High-Fat Diet-Induced Obesity, and Acetylshikonin, a Main Compound of Lithospermum erythrorhizon, Inhibits Adipocyte Differentiation
- (2012) So Young Gwon et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Addition of β-Lactoglobulin Produces Water-Soluble Shikonin
- (2012) Alen Albreht et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
- (2012) Michael T. Heneka et al. NATURE
- The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP
- (2012) Geun-Shik Lee et al. NATURE
- Regulation of inflammasome signaling
- (2012) Vijay A K Rathinam et al. NATURE IMMUNOLOGY
- Critical role for calcium mobilization in activation of the NLRP3 inflammasome
- (2012) T. Murakami et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors
- (2012) Manuela Rossol et al. Nature Communications
- Electrospun fiber mats containing shikonin and derivatives with potential biomedical applications
- (2011) Konstantinos N. Kontogiannopoulos et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
- (2011) Bolormaa Vandanmagsar et al. NATURE MEDICINE
- Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
- (2011) J Chen et al. ONCOGENE
- The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes
- (2011) Rebecca C. Coll et al. PLoS One
- Shikonin reduces oedema induced by phorbol ester by interfering with IκBα degradation thus inhibiting translocation of NF-κB to the nucleus
- (2010) I Andújar et al. BRITISH JOURNAL OF PHARMACOLOGY
- Anti-inflammatory Compounds Parthenolide and Bay 11-7082 Are Direct Inhibitors of the Inflammasome
- (2010) Christine Juliana et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia
- (2010) M. Lamkanfi et al. JOURNAL OF IMMUNOLOGY
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
- (2010) Peter Duewell et al. NATURE
- Necrostatin-1 reverts shikonin-induced necroptosis to apoptosis
- (2009) Weidong Han et al. APOPTOSIS
- Electrospun shikonin-loaded PCL/PTMC composite fiber mats with potential biomedical applications
- (2009) Jie Han et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- Thioredoxin-interacting protein links oxidative stress to inflammasome activation
- (2009) Rongbin Zhou et al. NATURE IMMUNOLOGY
- Shikonin derivatives inhibited LPS-induced NOS in RAW 264.7 cells via downregulation of MAPK/NF-κB signaling
- (2008) Yu Wen Cheng et al. JOURNAL OF ETHNOPHARMACOLOGY
- Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
- (2008) Veit Hornung et al. NATURE IMMUNOLOGY
- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
- (2008) Annett Halle et al. NATURE IMMUNOLOGY
- Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
- (2008) C. Dostert et al. SCIENCE
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search