NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity
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Title
NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity
Authors
Keywords
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Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 69, Issue 24, Pages 4215-4228
Publisher
Springer Nature
Online
2012-08-28
DOI
10.1007/s00018-012-1140-0
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Note: Only part of the references are listed.- Antibody-Mediated Inhibition of Integrin α5β1 Blocks Neurotoxic Prion Peptide PrP106–126-Induced Activation of BV2 Microglia
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- The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation
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- Introduction of glutamines into the B2–H2 loop promotes prion protein conversion
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- Globular Domain of the Prion Protein Needs to Be Unlocked by Domain Swapping to Support Prion Protein Conversion
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- Serum Amyloid A Activates the NLRP3 Inflammasome via P2X7 Receptor and a Cathepsin B-Sensitive Pathway
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- Effect of Hydrophobic Mutations in the H2-H3 Subdomain of Prion Protein on Stability and Conversion In Vitro and In Vivo
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- Mammalian Prions Generated from Bacterially Expressed Prion Protein in the Absence of Any Mammalian Cofactors
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- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
- (2010) Peter Duewell et al. NATURE
- Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
- (2010) Seth L Masters et al. NATURE IMMUNOLOGY
- Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses
- (2010) M. Ritter et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Generating a Prion with Bacterially Expressed Recombinant Prion Protein
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- The Physical Relationship between Infectivity and Prion Protein Aggregates Is Strain-Dependent
- (2010) Philippe Tixador et al. PLoS Pathogens
- Analysis of Protein Levels of 24 Cytokines in Scrapie Agent-Infected Brain and Glial Cell Cultures from Mice Differing in Prion Protein Expression Levels
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- CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
- (2009) Cameron R Stewart et al. NATURE IMMUNOLOGY
- Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
- (2009) Fiona A. Sharp et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genes contributing to prion pathogenesis
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- Accelerated Prion Disease Pathogenesis in Toll-Like Receptor 4 Signaling-Mutant Mice
- (2008) D. S. Spinner et al. JOURNAL OF VIROLOGY
- Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
- (2008) Veit Hornung et al. NATURE IMMUNOLOGY
- The NALP3 inflammasome is involved in the innate immune response to amyloid-β
- (2008) Annett Halle et al. NATURE IMMUNOLOGY
- Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica
- (2008) C. Dostert et al. SCIENCE
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