An agnostic reevaluation of the amyloid cascade hypothesis of Alzheimer's disease pathogenesis: The role of APP homeostasis

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Secreted amyloid-β precursor protein functions as a GABABR1a ligand to modulate synaptic transmission

(2019) Heather C. Rice et al.   SCIENCE

Secreted APP Modulates Synaptic Activity: A Novel Target for Therapeutic Intervention?

(2019) Christian Haass et al.   NEURON

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Frontal cortex and striatal cellular and molecular pathobiology in individuals with Down syndrome with and without dementia

(2019) Sylvia E. Perez et al.   ACTA NEUROPATHOLOGICA

A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer’s disease dementia

(2019) Michael J Pontecorvo et al.   BRAIN

Randomized Trial of Verubecestat for Prodromal Alzheimer’s Disease

(2019) Michael F. Egan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

Genetic predisposition, modifiable-risk-factor profile and long-term dementia risk in the general population

(2019) Silvan Licher et al.   NATURE MEDICINE

Neuropsychological decline up to 20 years before incident mild cognitive impairment

(2019) Richard J. Caselli et al.   Alzheimers & Dementia

Resistance to autosomal dominant Alzheimer’s disease in an APOE3 Christchurch homozygote: a case report

(2019) Joseph F. Arboleda-Velasquez et al.   NATURE MEDICINE

Objective subtle cognitive difficulties predict future amyloid accumulation and neurodegeneration

(2019) Kelsey R. Thomas et al.   NEUROLOGY

Person-specific contribution of neuropathologies to cognitive loss in old age

(2018) Patricia A. Boyle et al.   ANNALS OF NEUROLOGY

Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition

(2018) Max C Richter et al.   EMBO JOURNAL

Profiles of β-Amyloid Peptides and Key Secretases in Brain Autopsy Samples Differ with Sex and APOE ε4 Status: Impact for Risk and Progression of Alzheimer Disease

(2018) Jennifer N.K. Nyarko et al.   NEUROSCIENCE

The age of onset and evolution of Braak tangle stage and Thal amyloid pathology of Alzheimer’s disease in individuals with Down syndrome

(2018) Yvonne S. Davidson et al.   Acta Neuropathologica Communications

Endothelium-specific amyloid precursor protein deficiency causes endothelial dysfunction in cerebral arteries

(2017) Livius V d’Uscio et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Understanding the roles of mutations in the amyloid precursor protein in Alzheimer disease

(2017) S Hunter et al.   MOLECULAR PSYCHIATRY

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Expression and Processing of Amyloid Precursor Protein in Vascular Endothelium

(2017) Livius V. d'Uscio et al.   PHYSIOLOGY

Therapeutic Potential of Secreted Amyloid Precursor Protein APPsα

(2017) Bruce G. Mockett et al.   Frontiers in Molecular Neuroscience

APOE2eases cognitive decline during Aging: Clinical and preclinical evaluations

(2016) Mitsuru Shinohara et al.   ANNALS OF NEUROLOGY

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence

(2016) Ayano Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Incidence of Dementia over Three Decades in the Framingham Heart Study

(2016) Claudia L. Satizabal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase

(2016) Linfeng Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease

(2016) Deepak Kumar Vijaya Kumar et al.   Science Translational Medicine

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

(2015) Paul Saftig et al.   PROGRESS IN NEUROBIOLOGY

Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity

(2014) Meike Hick et al.   ACTA NEUROPATHOLOGICA

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

Increased CSF APPs-  levels in patients with Alzheimer disease treated with acitretin

(2014) K. Endres et al.   NEUROLOGY

Diurnal Patterns of Soluble Amyloid Precursor Protein Metabolites in the Human Central Nervous System

(2014) Justyna A. Dobrowolska et al.   PLoS One

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Redundancy and divergence in the amyloid precursor protein family

(2013) S. Ali M. Shariati et al.   FEBS LETTERS

Soluble amyloid precursor protein-α rescues age-linked decline in neural progenitor cell proliferation

(2013) Michael P. Demars et al.   NEUROBIOLOGY OF AGING

Amyloid deposition is decreasing in aging brains: An autopsy study of 1,599 older people

(2013) E. Kovari et al.   NEUROLOGY

A Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease

(2013) Rachelle S. Doody et al.   NEW ENGLAND JOURNAL OF MEDICINE

Physiological Functions of APP Family Proteins

(2013) U. C. Muller et al.   Cold Spring Harbor Perspectives in Medicine

Origins of Alzheimerʼs disease

(2012) Erik S. Musiek et al.   CURRENT OPINION IN NEUROLOGY

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers

(2012) M. Scholl et al.   NEUROLOGY

Autosomal Recessive Causes Likely in Early-Onset Alzheimer Disease

(2011) Thomas S. Wingo   ARCHIVES OF NEUROLOGY

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

(2011) Robert Tamayev et al.   EMBO Molecular Medicine

Functions of Aβ, sAPPα and sAPPβ : similarities and differences

(2011) Stéphanie Chasseigneaux et al.   JOURNAL OF NEUROCHEMISTRY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

(2011) Berislav V. Zlokovic   NATURE REVIEWS NEUROSCIENCE

Longitudinal modeling of frontal cognition in APOE  4 homozygotes, heterozygotes, and noncarriers

(2011) R. J. Caselli et al.   NEUROLOGY

Amyloid precursor protein is required for convergent-extension movements during Zebrafish development

(2009) Powrnima Joshi et al.   DEVELOPMENTAL BIOLOGY

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity

(2009) Minji Kim et al.   HUMAN MOLECULAR GENETICS

Longitudinal Modeling of Age-Related Memory Decline and theAPOEε4 Effect

(2009) Richard J. Caselli et al.   NEW ENGLAND JOURNAL OF MEDICINE