Functions of Aβ, sAPPα and sAPPβ : similarities and differences

Novel AβIsoforms in Alzheimer's Disease - Their Role in Diagnosis and Treatment

(2012) Erik Portelius et al.   CURRENT PHARMACEUTICAL DESIGN

The E2 Domains of APP and APLP1 Share a Conserved Mode of Dimerization

(2011) Sangwon Lee et al.   BIOCHEMISTRY

The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains

(2011) Frances Corrigan et al.   BRAIN RESEARCH

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

Soluble Amyloid Precursor Protein Induces Rapid Neural Differentiation of Human Embryonic Stem Cells

(2011) Kristine K. Freude et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secreted Amyloid Precursor Protein β and Secreted Amyloid Precursor Protein α Induce Axon Outgrowth In Vitro through Egr1 Signaling Pathway

(2011) Stéphanie Chasseigneaux et al.   PLoS One

sAPPα antagonizes dendritic degeneration and neuron death triggered by proteasomal stress

(2010) Ekaterini Copanaki et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Calcineurin-mediated Endocytosis and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors Prevents Amyloid β Oligomer-induced Synaptic Disruption

(2009) Wei-Qin Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Amyloid Monomers Are Neuroprotective

(2009) M. L. Giuffrida et al.   JOURNAL OF NEUROSCIENCE

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

(2009) Anatoly Nikolaev et al.   NATURE

SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Aβ-Degrading Enzymes in Alzheimer's Disease

(2008) James Scott Miners et al.   BRAIN PATHOLOGY

Amyloid Precursor Protein Is a Primary Androgen Target Gene That Promotes Prostate Cancer Growth

(2008) K.-i. Takayama et al.   CANCER RESEARCH

Aβ40 promotes neuronal cell fate in neural progenitor cells

(2008) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Activity requires soluble amyloid precursor protein α to promote neurite outgrowth in neural stem cell-derived neurons via activation of the MAPK pathway

(2008) Nidhi Gakhar-Koppole et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Homophilic Interactions of the Amyloid Precursor Protein (APP) Ectodomain Are Regulated by the Loop Region and Affect β-Secretase Cleavage of APP

(2008) Daniela Kaden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloidogenic Processing but Not Amyloid Precursor Protein (APP) Intracellular C-terminal Domain Production Requires a Precisely Oriented APP Dimer Assembled by Transmembrane GXXXG Motifs

(2008) Pascal Kienlen-Campard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sortilin-related Receptor with A-type Repeats (SORLA) Affects the Amyloid Precursor Protein-dependent Stimulation of ERK Signaling and Adult Neurogenesis

(2008) Michael Rohe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Secreted APP regulates the function of full-length APP in neurite outgrowth through interaction with integrin beta1

(2008) Tracy L Young-Pearse et al.   Neural Development

Aβ1–42 stimulates adult SVZ neurogenesis through the p75 neurotrophin receptor

(2008) Areechun Sotthibundhu et al.   NEUROBIOLOGY OF AGING

Endogenous secreted amyloid precursor protein-α regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory

(2008) Chanel J. Taylor et al.   NEUROBIOLOGY OF DISEASE

Upregulation of ??-amyloid precursor protein expression in glioblastoma multiforme

(2008) Frank Culicchia et al.   NEUROREPORT

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of A  toxicity

(2008) J. N. Buxbaum et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA