Actionable Potentials of Less Frequently Mutated Genes in Colorectal Cancer and Their Roles in Precision Medicine

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

FBXW7 in Cancer: What Has Been Unraveled Thus Far?

(2019) Bethsebie Lalduhsaki Sailo et al.   Cancers

Systemic treatment for metastatic colorectal cancer in the era of precision medicine

(2019) Jaideep Sandhu et al.   JOURNAL OF SURGICAL ONCOLOGY

Emerging Roles of C-Myc in Cancer Stem Cell-Related Signaling and Resistance to Cancer Chemotherapy: A Potential Therapeutic Target Against Colorectal Cancer

(2019) Mohamed Elbadawy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ARID1a as a marker of prognosis and increased sensitivity to CDK4/6, mTOR 1/2 and Src homology region 2 phosphatase (SHP 1/2) inhibitors in breast cancer (BC).

(2019) Veronica Mariotti et al.   JOURNAL OF CLINICAL ONCOLOGY

Evaluation of antitumor effects of aspirin and LGK974 drugs on cellular signaling pathways, cell cycle and apoptosis in colorectal cancer cell lines compared to oxaliplatin drug

(2019) Malihe Bagheri et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

V211D mutation in MEK1 causes resistance to MEK inhibitors in colon cancer

(2019) Yijun Gao et al.   Cancer Discovery

ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells

(2019) Madhobi Sen et al.   Clinical Epigenetics

Genomic Profiling of KRAS/NRAS/BRAF/PIK3CA Wild-Type Metastatic Colorectal Cancer Patients Reveals Novel Mutations in Genes Potentially Associated with Resistance to Anti-EGFR Agents

(2019) Anna Maria Rachiglio et al.   Cancers

Targeting ARID1A-mutant colorectal cancer: depletion of ARID1B increases radiosensitivity and modulates DNA damage response

(2019) B. Niedermaier et al.   Scientific Reports

ARID1A mutant ovarian clear cell carcinoma: A clear target for synthetic lethal strategies

(2018) Joseph J. Caumanns et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

SMAD4 and NF1 mutations as potential biomarkers for poor prognosis to cetuximab-based therapy in Chinese metastatic colorectal cancer patients

(2018) Zhu Mei et al.   BMC CANCER

Mutation analysis of adenomas and carcinomas of the colon: Early and late drivers

(2018) Roger K. Wolff et al.   GENES CHROMOSOMES & CANCER

The role of TGF-β/SMAD4 signaling in cancer

(2018) Ming Zhao et al.   International Journal of Biological Sciences

ARID1B as a Potential Therapeutic Target for ARID1A-Mutant Ovarian Clear Cell Carcinoma

(2018) Emi Sato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of loss-of-function mutations at the RNF43 locus on colorectal cancer development and progression

(2018) Tsugio Eto et al.   JOURNAL OF PATHOLOGY

Mechanisms of receptor tyrosine kinase activation in cancer

(2018) Zhenfang Du et al.   Molecular Cancer

LRP1 expression in colon cancer predicts clinical outcome

(2018) Camille Boulagnon-Rombi et al.   Oncotarget

The characteristics of ARID1A mutations in colorectal cancer.

(2018) Amir Mehrvarz Sarshekeh et al.   JOURNAL OF CLINICAL ONCOLOGY

FBXW7: a critical tumor suppressor of human cancers

(2018) Chien-Hung Yeh et al.   Molecular Cancer

Drug resistance and new therapies in colorectal cancer

(2018) Kevin Van der Jeught et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Loss of endogenous RNF43 function enhances proliferation and tumour growth of intestinal and gastric cells

(2018) Victoria Neumeyer et al.   CARCINOGENESIS

SMAD4 loss in colorectal cancer patients correlates with recurrence, loss of immune infiltrate, and chemoresistance

(2018) Isaac Wasserman et al.   CLINICAL CANCER RESEARCH

The fibrinolytic factor tPA drives LRP1-mediated melanoma growth and metastasis

(2018) Yousef Salama et al.   FASEB JOURNAL

Challenges in Stratifying the Molecular Variability of Patient-Derived Colon Tumor Xenografts

(2018) Magdalena Cybulska et al.   Biomed Research International

Association Between c-Myc and Colorectal Cancer Prognosis: A Meta-Analysis

(2018) Wei-Ling He et al.   Frontiers in Physiology

Down-regulation of LRP1B in colon cancer promoted the growth and migration of cancer cells

(2017) Zhiqiang Wang et al.   EXPERIMENTAL CELL RESEARCH

Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer

(2017) Barbara Jung et al.   GASTROENTEROLOGY

Single-cell DNA sequencing reveals a late-dissemination model in metastatic colorectal cancer

(2017) Marco L. Leung et al.   GENOME RESEARCH

Rnf43

(2017) Stefano Serra et al.   JOURNAL OF CLINICAL PATHOLOGY

Study of NOTCH1 and FBXW7 Mutations and Its Prognostic Significance in South Indian T-Cell Acute Lymphoblastic Leukemia

(2017) Natarajan Valliyammai et al.   JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY

Comparative analysis of the EGFR, HER2, c-MYC, and MET variations in colorectal cancer determined by three different measures: gene copy number gain, amplification status and the 2013 ASCO/CAP guideline criterion for HER2 testing of breast cancer

(2017) Yoonjin Kwak et al.   Journal of Translational Medicine

AACR Project GENIE: Powering Precision Medicine through an International Consortium

(2017)   Cancer Discovery

FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma

(2017) Krittiya Korphaisarn et al.   Oncotarget

Unique characteristics of ARID1A mutation and protein level in gastric and colorectal cancer: A meta-analysis

(2017) Ju-Han Lee et al.   Saudi Journal of Gastroenterology

Molecular Characterization of Somatic Alterations in Dukes’ B and C Colorectal Cancers by Targeted Sequencing

(2017) Shafina-Nadiawati Abdul et al.   Frontiers in Pharmacology

Association of SMAD4 mutation with patient demographics, tumor characteristics, and clinical outcomes in colorectal cancer

(2017) Amir Mehrvarz Sarshekeh et al.   PLoS One

Integrated analysis of gene expression and copy number identified potential cancer driver genes with amplification-dependent overexpression in 1,454 solid tumors

(2017) Keiichi Ohshima et al.   Scientific Reports

Spectrum of Gene Mutations in Colorectal Cancer

(2016) Rodrigo Dienstmann et al.   CANCER JOURNAL

Global patterns and trends in colorectal cancer incidence and mortality

(2016) Melina Arnold et al.   GUT

RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation

(2016) Helen H N Yan et al.   GUT

Partial Müllerian Duct Retention in Smad4 Conditional Mutant Male Mice

(2016) Fabrice G. Petit et al.   International Journal of Biological Sciences

Less frequently mutated genes in colorectal cancer: evidences from next-generation sequencing of 653 routine cases

(2016) Umberto Malapelle et al.   JOURNAL OF CLINICAL PATHOLOGY

FBW7 mutations mediate resistance of colorectal cancer to targeted therapies by blocking Mcl-1 degradation

(2016) J Tong et al.   ONCOGENE

Sequencing Structural Variants in Cancer for Precision Therapeutics

(2016) Geoff Macintyre et al.   TRENDS IN GENETICS

Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy

(2016) Cristiana Lo Nigro et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Role of LRP-1 in cancer cell migration in 3-dimensional collagen matrix

(2016) Aline Appert-Collin et al.   Cell Adhesion & Migration

Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer

(2016) Hassan Ashktorab et al.   Oncotarget

RNF43 and ZNRF3 are commonly altered in serrated pathway colorectal tumorigenesis

(2016) Catherine E. Bond et al.   Oncotarget

Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma

(2016) Marios Giannakis et al.   Cell Reports

Establishment of a Novel Model for Anticancer Drug Resistance in Three-Dimensional Primary Culture of Tumor Microenvironment

(2016) Tatsuya Usui et al.   Stem Cells International

Control of Wnt Receptor Turnover by R-spondin-ZNRF3/RNF43 Signaling Module and Its Dysregulation in Cancer

(2016) Huai-Xiang Hao et al.   Cancers

Inter- and intra-tumor profiling of multi-regional colon cancer and metastasis

(2015) Akihiro Kogita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting FGFR Signaling in Cancer

(2015) M. Touat et al.   CLINICAL CANCER RESEARCH

The FGFR Landscape in Cancer: Analysis of 4,853 Tumors by Next-Generation Sequencing

(2015) T. Helsten et al.   CLINICAL CANCER RESEARCH

Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations

(2015) Leandro H. Gallo et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling

(2015) Tadasuke Tsukiyama et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeting the WNT Signaling Pathway in Cancer Therapeutics

(2015) D. Tai et al.   ONCOLOGIST

Smad4 sensitizes colorectal cancer to 5-fluorouracil through cell cycle arrest by inhibiting the PI3K/Akt/CDC2/survivin cascade

(2015) BINHAO ZHANG et al.   ONCOLOGY REPORTS

ZNRF3/RNF43 – A direct linkage of extracellular recognition and E3 ligase activity to modulate cell surface signalling

(2015) Matthias Zebisch et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane

(2015) Anke Loregger et al.   Science Signaling

The E3 ligase RNF43 inhibits Wnt signaling downstream of mutated β-catenin by sequestering TCF4 to the nuclear membrane

(2015) Anke Loregger et al.   Science Signaling

Pharmacologic resistance in colorectal cancer: a review

(2015) William A. Hammond et al.   Therapeutic Advances in Medical Oncology

PacBio Sequencing and Its Applications

(2015) Anthony Rhoads et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

c-MYC Copy-Number Gain Is an Independent Prognostic Factor in Patients with Colorectal Cancer

(2015) Kyu Sang Lee et al.   PLoS One

Clinicopathologic and prognostic relevance of ARID1A protein loss in colorectal cancer

(2015) Xiao-Li Wei   WORLD JOURNAL OF GASTROENTEROLOGY

Concordant analysis of KRAS, BRAF, PIK3CA mutations and PTEN expression between primary colorectal cancer and matched metastases

(2015) Chen Mao et al.   Scientific Reports

Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway

(2014) B Zhang et al.   BRITISH JOURNAL OF CANCER

Novel recurrently mutated genes and a prognostic mutation signature in colorectal cancer

(2014) Jun Yu et al.   GUT

Exome sequencing reveals frequent inactivating mutations inARID1A, ARID1B, ARID2andARID4Ain microsatellite unstable colorectal cancer

(2014) Tatiana Cajuso et al.   INTERNATIONAL JOURNAL OF CANCER

Discovery and saturation analysis of cancer genes across 21 tumour types

(2014) Michael S. Lawrence et al.   NATURE

RNF43 is frequently mutated in colorectal and endometrial cancers

(2014) Marios Giannakis et al.   NATURE GENETICS

ARID1B is a specific vulnerability in ARID1A-mutant cancers

(2014) Katherine C Helming et al.   NATURE MEDICINE

FBXW7 Mutations in Patients with Advanced Cancers: Clinical and Molecular Characteristics and Outcomes with mTOR Inhibitors

(2014) Denis L. Jardim et al.   PLoS One

FGFR2 Is Amplified in the NCI-H716 Colorectal Cancer Cell Line and Is Required for Growth and Survival

(2014) Anjili Mathur et al.   PLoS One

Decreased ARID1A expression facilitates cell proliferation and inhibits 5-fluorouracil-induced apoptosis in colorectal carcinoma

(2014) Chengyao Xie et al.   TUMOR BIOLOGY

Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer

(2014) R C Turkington et al.   Cell Death & Disease

Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors

(2013) R. Dienstmann et al.   ANNALS OF ONCOLOGY

FGFR2 Gene Amplification in Gastric Cancer Predicts Sensitivity to the Selective FGFR Inhibitor AZD4547

(2013) L. Xie et al.   CLINICAL CANCER RESEARCH

Prognostic Significance of Fbw7 in Human Melanoma and Its Role in Cell Migration

(2013) Yabin Cheng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inactivating mutations of RNF43 confer Wnt dependency in pancreatic ductal adenocarcinoma

(2013) X. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Fibroblast Growth Factor Receptor Inhibitors as a Cancer Treatment: From a Biologic Rationale to Medical Perspectives

(2013) Maria Vittoria Dieci et al.   Cancer Discovery

LRP-1: A Checkpoint for the Extracellular Matrix Proteolysis

(2013) Nicolas Etique et al.   Biomed Research International

Cross-suppression of EGFR ligands amphiregulin and epiregulin and de-repression of FGFR3 signalling contribute to cetuximab resistance in wild-type KRAS tumour cells

(2012) C Oliveras-Ferraros et al.   BRITISH JOURNAL OF CANCER

SMAD2, SMAD3 and SMAD4 Mutations in Colorectal Cancer

(2012) N. I. Fleming et al.   CANCER RESEARCH

FBXW7-mediated degradation of CCDC6 is impaired by ATM during DNA damage response in lung cancer cells

(2012) Zhao JunGang et al.   FEBS LETTERS

Regulation of EMT by TGFβ in cancer

(2012) Carl-Henrik Heldin et al.   FEBS LETTERS

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

The genetic landscape of mutations in Burkitt lymphoma

(2012) Cassandra Love et al.   NATURE GENETICS

Low Level of Low-Density Lipoprotein Receptor-Related Protein 1 Predicts an Unfavorable Prognosis of Hepatocellular Carcinoma after Curative Resection

(2012) Xiao-Yong Huang et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Contribution of Large Genomic Rearrangements in Italian Lynch Syndrome Patients: Characterization of a Novel Alu-Mediated Deletion

(2012) Francesca Duraturo et al.   Biomed Research International

The TGFbeta Superfamily Signaling Pathway

(2012) Alexander Weiss et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Increased burden of colorectal cancer in Asia

(2012) Mohamad Amin Pourhoseingholi   World Journal of Gastrointestinal Oncology

Stromal LRP1 in Lung Adenocarcinoma Predicts Clinical Outcome

(2011) H. Meng et al.   CLINICAL CANCER RESEARCH

Smad4-Mediated Signaling Inhibits Intestinal Neoplasia by Inhibiting Expression of β-Catenin

(2011) Tanner J. Freeman et al.   GASTROENTEROLOGY

Low-density lipoprotein receptor-related protein 1 (LRP-1) is associated with high-grade, advanced stage and p53 and p16 alterations in endometrial carcinomas

(2011) Lluis Catasús et al.   HISTOPATHOLOGY

Low-density lipoprotein receptor–related protein 1 is associated with proliferation and invasiveness in Her-2/neu and triple-negative breast carcinomas

(2011) Lluis Catasus et al.   HUMAN PATHOLOGY

High SMAD4 levels appear in microsatellite instability and hypermethylated colon cancers, and indicate a better prognosis

(2011) Martin Isaksson-Mettävainio et al.   INTERNATIONAL JOURNAL OF CANCER

FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer

(2010) N. Turner et al.   CANCER RESEARCH

Rapidly Acquired Resistance to EGFR Tyrosine Kinase Inhibitors in NSCLC Cell Lines through De-Repression of FGFR2 and FGFR3 Expression

(2010) Kathryn E. Ware et al.   PLoS One

Low-Density Lipoprotein Receptor-Related Protein 1 Promotes Cancer Cell Migration and Invasion by Inducing the Expression of Matrix Metalloproteinases 2 and 9

(2009) H. Song et al.   CANCER RESEARCH

Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: Clinical significance

(2009) Masaaki Iwatsuki et al.   INTERNATIONAL JOURNAL OF CANCER

LDL Receptor-Related Protein 1: Unique Tissue-Specific Functions Revealed by Selective Gene Knockout Studies

(2008) Anna P. Lillis et al.   PHYSIOLOGICAL REVIEWS

FBXW7 Targets mTOR for Degradation and Cooperates with PTEN in Tumor Suppression

(2008) Jian-Hua Mao et al.   SCIENCE