Loss of Smad4 in colorectal cancer induces resistance to 5-fluorouracil through activating Akt pathway

Cancer statistics, 2012

(2012) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Prognostic Value of Reduced SMAD4 Expression in Patients With Metastatic Colorectal Cancer Under Oxaliplatin-Containing Chemotherapy: A Translational Study of the AIO Colorectal Study Group

(2012) Alexander Baraniskin et al.   Clinical Colorectal Cancer

Integrated Analysis of Molecular and Clinical Prognostic Factors in Stage II/III Colon Cancer

(2012) A. D. Roth et al.   JNCI-Journal of the National Cancer Institute

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Smad4 Inactivation Promotes Malignancy and Drug Resistance of Colon Cancer

(2011) P. Papageorgis et al.   CANCER RESEARCH

14-3-3σ regulation by p53 mediates a chemotherapy response to 5-fluorouracil in MCF-7 breast cancer cells via Akt inactivation

(2011) Guopei Zheng et al.   FEBS LETTERS

Smad4-Mediated Signaling Inhibits Intestinal Neoplasia by Inhibiting Expression of β-Catenin

(2011) Tanner J. Freeman et al.   GASTROENTEROLOGY

Smad4 May Help to Identify a Subset of Colorectal Cancer Patients with Early Recurrence after Curative Therapy

(2011) Byung Kyu Ahn et al.   HEPATO-GASTROENTEROLOGY

Amplified in breast cancer 1 enhances human cholangiocarcinoma growth and chemoresistance by simultaneous activation of Akt and Nrf2 pathways

(2011) Qiang Chen et al.   HEPATOLOGY

LY294002 may overcome 5-FU resistance via down-regulation of activated p-AKT in Epstein-Barr virus-positive gastric cancer cells

(2010) Jung-Young Shin et al.   BMC CANCER

Intracrine vascular endothelial growth factor signaling in survival and chemoresistance of human colorectal cancer cells

(2010) S Samuel et al.   ONCOGENE

Activation of Wnt/β-catenin signalling pathway induces chemoresistance to interferon-α/5-fluorouracil combination therapy for hepatocellular carcinoma

(2009) T Noda et al.   BRITISH JOURNAL OF CANCER

Targeting transforming growth factor-β signaling in liver metastasis of colon cancer

(2009) Bixiang Zhang et al.   CANCER LETTERS

Antimetastatic Role of Smad4 Signaling in Colorectal Cancer

(2009) Bixiang Zhang et al.   GASTROENTEROLOGY

Effective Treatment of Advanced Colorectal Cancer by Rapamycin and 5-FU/Oxaliplatin Monitored by TIMP-1

(2009) Markus Wagner et al.   JOURNAL OF GASTROINTESTINAL SURGERY

A metastatic colon cancer model using nonoperative transanal rectal injection

(2009) Melissa Donigan et al.   SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES

TGFβ in Cancer

(2008) Joan Massagué   CELL

Inhibition of Src tyrosine kinase reverts chemoresistance toward 5-fluorouracil in human pancreatic carcinoma cells: an involvement of epidermal growth factor receptor signaling

(2008) I Ischenko et al.   ONCOGENE

Akt Regulates Drug-Induced Cell Death through Bcl-w Downregulation

(2008) Michela Garofalo et al.   PLoS One